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Items: 6

1.

tacrolimus

A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [from NCI]

MedGen UID:
43111
Concept ID:
C0085149
Organic Chemical; Pharmacologic Substance
2.

Calcipotriene preparation

A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04) [from NCI]

MedGen UID:
32492
Concept ID:
C0065767
Organic Chemical; Pharmacologic Substance
3.

Psoriasis

A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. [from MeSH]

MedGen UID:
10997
Concept ID:
C0033860
Disease or Syndrome
4.

Chronic small plaque psoriasis

MedGen UID:
590303
Concept ID:
C0406317
Disease or Syndrome
5.

Psoriasis

A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales). [from HPO]

MedGen UID:
505592
Concept ID:
CN003401
Finding
6.

Plaque

Abnormal tissue that results from the progressive accumulation or deposit of certain substances in a body cavity, surface, or lumen. [from NCI]

MedGen UID:
452424
Concept ID:
C0332461
Finding
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