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Lung adenocarcinoma

MedGen UID:
57744
Concept ID:
C0152013
Neoplastic Process
Synonyms: Adenocarcinoma of lung; Adenocarcinoma of lung, somatic
SNOMED CT: Adenocarcinoma of lung (254626006)
 
OMIM®: 211980
HPO: HP:0030078

Definition

A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor. [from NCI]

Conditions with this feature

Li-Fraumeni syndrome 1
MedGen UID:
322656
Concept ID:
C1835398
Disease or Syndrome
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with the development of the following classic tumors: soft tissue sarcoma, osteosarcoma, pre-menopausal breast cancer, brain tumors, adrenocortical carcinoma (ACC), and leukemias. In addition, a variety of other neoplasms may occur. LFS-related cancers often occur in childhood or young adulthood and survivors have an increased risk for multiple primary cancers. Age-specific cancer risks have been calculated.
Tumor susceptibility linked to germline BAP1 mutations
MedGen UID:
482122
Concept ID:
C3280492
Disease or Syndrome
BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for the specific skin lesion – atypical Spitz tumors – and the following cancers, in descending order of frequency: uveal (eye) melanoma (UM), malignant mesothelioma (MMe), cutaneous melanoma (CM), clear cell renal cell carcinoma (ccRCC), and basal cell carcinoma (BCC). Affected individuals can have more than one type of primary cancer. In general the median age of onset of these tumors is younger than in the general population. UM tends to be a more aggressive class 2 tumor with higher risk for metastasis and reduced survival compared to UM that occurs in the general population. However, because of the limited number of families reported to date, the penetrance, natural history, and frequencies of the BAP1-associated tumors are yet to be determined. Other suspected but unconfirmed tumors in BAP1-TPDS include (in alphabetic order): breast cancer, cholangiocarcinoma, non-small cell lung adenocarcinoma (NSCLC), meningioma, and neuroendocrine carcinoma.

Professional guidelines

PubMed

Leighl NB, Rekhtman N, Biermann WA, Huang J, Mino-Kenudson M, Ramalingam SS, West H, Whitlock S, Somerfield MR
J Clin Oncol 2014 Nov 10;32(32):3673-9. Epub 2014 Oct 13 doi: 10.1200/JCO.2014.57.3055. PMID: 25311215Free PMC Article
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Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar JS, Squire J, Thunnissen E, Ladanyi M, College of American Pathologists International Association for the Study of Lung Cancer and Association for Molecular Pathology
J Mol Diagn 2013 Jul;15(4):415-53. Epub 2013 Apr 4 doi: 10.1016/j.jmoldx.2013.03.001. PMID: 23562183

External

EGFR-TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer

Recent clinical studies

Etiology

Han L, Lee CK, Pang H, Chan HT, Lo IL, Lam SK, Cheong TH, Ho JC
Lung Cancer 2017 Dec;114:79-89. Epub 2017 Oct 31 doi: 10.1016/j.lungcan.2017.10.012. PMID: 29173771
Guo T, Zhao S, Wang P, Xue X, Zhang Y, Yang M, Li N, Li Z, Xu L, Jiang L, Zhao L, Ma PC, Rosell R, Li J, Gu C
Oncotarget 2017 Jul 18;8(29):48110-48125. doi: 10.18632/oncotarget.18262. PMID: 28624808Free PMC Article
Wu S, Shi X, Sun J, Liu Y, Luo Y, Liang Z, Wang J, Zeng X
Oncotarget 2017 Mar 7;8(10):16421-16429. doi: 10.18632/oncotarget.14851. PMID: 28145884Free PMC Article
Zhang Y, Yu K, Hu S, Lou Y, Liu C, Xu J, Li R, Zhang X, Wang H, Han B
Oncotarget 2016 Dec 13;7(50):83051-83059. doi: 10.18632/oncotarget.13031. PMID: 27811371Free PMC Article
Wang G, Wang H, Zhang C, Liu T, Li Q, Lin X, Xie J, Liu H
Tumour Biol 2016 Sep;37(9):12597-12607. Epub 2016 Jul 11 doi: 10.1007/s13277-016-5126-7. PMID: 27402308

Diagnosis

Motono N, Matsui T, Machida Y, Usuda K, Uramoto H
Med Oncol 2017 Jun;34(6):100. Epub 2017 Apr 21 doi: 10.1007/s12032-017-0962-x. PMID: 28432617
Nie Y, Gao W, Li N, Chen W, Wang H, Li C, Zhang H, Han P, Zhang Y, Lv X, Xu X, Liu H
World J Surg Oncol 2017 Mar 3;15(1):55. doi: 10.1186/s12957-017-1103-x. PMID: 28253871Free PMC Article
Feng M, Zhu J, Liang L, Zeng N, Wu Y, Wan C, Shen Y, Wen F
Int J Clin Oncol 2017 Apr;22(2):283-290. Epub 2016 Dec 18 doi: 10.1007/s10147-016-1073-y. PMID: 27990560
Zhang Y, Yu K, Hu S, Lou Y, Liu C, Xu J, Li R, Zhang X, Wang H, Han B
Oncotarget 2016 Dec 13;7(50):83051-83059. doi: 10.18632/oncotarget.13031. PMID: 27811371Free PMC Article
Wang Y, Zhang W, Wen L, Yang H, Wen M, Yun Y, Zhao L, Zhu X, Tian L, Luo E, Li Y, Liu W, Wen N
Oncotarget 2016 Sep 13;7(37):59245-59259. doi: 10.18632/oncotarget.11043. PMID: 27494877Free PMC Article

Therapy

Xu X, Yu S, Sun W, Qin X, Chen Y, Zhou L, Lou R, Dong S, Shen B, Wu J, Zang J, Cao H, Shi M, Zhang Q, Feng J
J Cancer Res Clin Oncol 2018 Mar;144(3):431-438. Epub 2017 Dec 29 doi: 10.1007/s00432-017-2562-8. PMID: 29288364
Chandrani P, Prabhash K, Prasad R, Sethunath V, Ranjan M, Iyer P, Aich J, Dhamne H, Iyer DN, Upadhyay P, Mohanty B, Chandna P, Kumar R, Joshi A, Noronha V, Patil V, Ramaswamy A, Karpe A, Thorat R, Chaudhari P, Ingle A, Choughule A, Dutt A
Ann Oncol 2017 Mar 1;28(3):597-603. doi: 10.1093/annonc/mdw636. PMID: 27998968Free PMC Article
Wang Y, Zhang W, Wen L, Yang H, Wen M, Yun Y, Zhao L, Zhu X, Tian L, Luo E, Li Y, Liu W, Wen N
Oncotarget 2016 Sep 13;7(37):59245-59259. doi: 10.18632/oncotarget.11043. PMID: 27494877Free PMC Article
Diao Y, Ma X, Min W, Lin S, Kang H, Dai Z, Wang X, Zhao Y
Cancer Lett 2016 Aug 28;379(1):12-23. Epub 2016 May 16 doi: 10.1016/j.canlet.2016.05.003. PMID: 27195913
Okayama A, Kimura Y, Miyagi Y, Oshima T, Oshita F, Ito H, Nakayama H, Nagashima T, Rino Y, Masuda M, Ryo A, Hirano H
J Proteomics 2016 Apr 29;139:60-6. Epub 2016 Mar 3 doi: 10.1016/j.jprot.2016.03.005. PMID: 26947549

Prognosis

Zhang ZW, Chen JJ, Xia SH, Zhao H, Yang JB, Zhang H, He B, Jiao J, Zhan BT, Sun CC
Gene 2018 Apr 15;650:60-67. Epub 2018 Jan 31 doi: 10.1016/j.gene.2018.01.096. PMID: 29408583
Gan XN, Luo J, Tang RX, Wang HL, Zhou H, Qin H, Gan TQ, Chen G
Tumour Biol 2017 May;39(5):1010428317705755. doi: 10.1177/1010428317705755. PMID: 28488527
Qixing M, Juqing X, Yajing W, Gaochao D, Wenjie X, Run S, Anpeng W, Lin X, Feng J, Jun W
Tumour Biol 2017 Apr;39(4):1010428317698340. doi: 10.1177/1010428317698340. PMID: 28381170
Wu S, Shi X, Sun J, Liu Y, Luo Y, Liang Z, Wang J, Zeng X
Oncotarget 2017 Mar 7;8(10):16421-16429. doi: 10.18632/oncotarget.14851. PMID: 28145884Free PMC Article
Zhang Y, Yu K, Hu S, Lou Y, Liu C, Xu J, Li R, Zhang X, Wang H, Han B
Oncotarget 2016 Dec 13;7(50):83051-83059. doi: 10.18632/oncotarget.13031. PMID: 27811371Free PMC Article

Clinical prediction guides

Zhang ZW, Chen JJ, Xia SH, Zhao H, Yang JB, Zhang H, He B, Jiao J, Zhan BT, Sun CC
Gene 2018 Apr 15;650:60-67. Epub 2018 Jan 31 doi: 10.1016/j.gene.2018.01.096. PMID: 29408583
Gan XN, Luo J, Tang RX, Wang HL, Zhou H, Qin H, Gan TQ, Chen G
Tumour Biol 2017 May;39(5):1010428317705755. doi: 10.1177/1010428317705755. PMID: 28488527
Qixing M, Juqing X, Yajing W, Gaochao D, Wenjie X, Run S, Anpeng W, Lin X, Feng J, Jun W
Tumour Biol 2017 Apr;39(4):1010428317698340. doi: 10.1177/1010428317698340. PMID: 28381170
Yuan XS, Cao LX, Hu YJ, Bao FC, Wang ZT, Cao JL, Yuan P, Lv W, Hu J
Tumour Biol 2017 Mar;39(3):1010428317694309. doi: 10.1177/1010428317694309. PMID: 28347242
Wu S, Shi X, Sun J, Liu Y, Luo Y, Liang Z, Wang J, Zeng X
Oncotarget 2017 Mar 7;8(10):16421-16429. doi: 10.18632/oncotarget.14851. PMID: 28145884Free PMC Article

Recent systematic reviews

Roca E, Gurizzan C, Amoroso V, Vermi W, Ferrari V, Berruti A
Cancer Treat Rev 2017 Sep;59:117-122. Epub 2017 Jul 31 doi: 10.1016/j.ctrv.2017.07.007. PMID: 28806542
Gan XN, Luo J, Tang RX, Wang HL, Zhou H, Qin H, Gan TQ, Chen G
Tumour Biol 2017 May;39(5):1010428317705755. doi: 10.1177/1010428317705755. PMID: 28488527
Feng M, Zhu J, Liang L, Zeng N, Wu Y, Wan C, Shen Y, Wen F
Int J Clin Oncol 2017 Apr;22(2):283-290. Epub 2016 Dec 18 doi: 10.1007/s10147-016-1073-y. PMID: 27990560
Morales-Oyarvide V, Mino-Kenudson M
Pathol Int 2016 Jan;66(1):1-7. Epub 2015 Dec 8 doi: 10.1111/pin.12368. PMID: 26642845
Hsiao SH, Lin HC, Chou YT, Lin SE, Kuo CC, Yu MC, Chung CL
Lung Cancer 2013 Sep;81(3):455-61. Epub 2013 Jul 18 doi: 10.1016/j.lungcan.2013.06.004. PMID: 23871711

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