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Items: 14

1.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
2.

Threonine

An essential amino acid in humans (provided by food), Threonine is an important residue of many proteins, such as tooth enamel, collagen, and elastin. An important amino acid for the nervous system, threonine also plays an important role in porphyrin and fat metabolism and prevents fat buildup in the liver. Useful with intestinal disorders and indigestion, threonine has also been used to alleviate anxiety and mild depression. (NCI04) [from NCI]

MedGen UID:
52734
Concept ID:
C0040005
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
3.

Tyrosine

A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. [from MeSH]

MedGen UID:
21746
Concept ID:
C0041485
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
4.

Serine

A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04) [from NCI]

MedGen UID:
11382
Concept ID:
C0036720
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
5.

Brain-Derived Neurotrophic Factor

Brain-derived neurotrophic factor (247 aa, ~28 kDa) is encoded by the human BDNF gene. This protein plays a role in both the development of the nervous system and neuronal survival. [from NCI]

MedGen UID:
760637
Concept ID:
C3486709
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
6.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
7.

Excitatory Amino Acid Agents

Drugs used for their actions on any aspect of excitatory amino acid neurotransmitter systems. Included are drugs that act on excitatory amino acid receptors, affect the life cycle of excitatory amino acid transmitters, or affect the survival of neurons using excitatory amino acids. [from MeSH]

MedGen UID:
116696
Concept ID:
C0242900
Pharmacologic Substance
8.

Neurotransmitter Agents

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. [from MeSH]

MedGen UID:
69321
Concept ID:
C0243051
Pharmacologic Substance
9.

Glutamate receptor antagonist

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. [from MeSH]

MedGen UID:
66180
Concept ID:
C0242910
Pharmacologic Substance
10.

D-Glutamate

MedGen UID:
49306
Concept ID:
C0112117
Amino Acid, Peptide, or Protein; Pharmacologic Substance
11.

Glutamic acid

A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. [from MeSH]

MedGen UID:
29630
Concept ID:
C0061472
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
12.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
13.

Drug interaction potentiation

MedGen UID:
636877
Concept ID:
C0521848
Disease or Syndrome
14.

GUANYLATE KINASE 3

MedGen UID:
331129
Concept ID:
C1841763
Finding
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