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Items: 12

1.

Microbicides, Topical

Generically, any topical agent that destroys microbes. However, usage of the term is increasingly being confined to topical agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES. [from MeSH]

MedGen UID:
209728
Concept ID:
C1136255
Pharmacologic Substance
2.

Vitiligo

Vitiligo is a condition that causes patchy loss of skin coloring (pigmentation). The average age of onset of vitiligo is in the mid-twenties, but it can appear at any age. It tends to progress over time, with larger areas of the skin losing pigment. Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body.Researchers have identified several forms of vitiligo. Generalized vitiligo (also called nonsegmental vitiligo), which is the most common form, involves loss of pigment (depigmentation) in patches of skin all over the body. Depigmentation typically occurs on the face, neck, and scalp, and around body openings such as the mouth and genitals. Sometimes pigment is lost in mucous membranes, such as the lips. Loss of pigmentation is also frequently seen in areas that tend to experience rubbing, impact, or other trauma, such as the hands, arms, and places where bones are close to the skin surface (bony prominences). Another form called segmental vitiligo is associated with smaller patches of depigmented skin that appear on one side of the body in a limited area; this occurs in about 10 percent of affected individuals.Vitiligo is generally considered to be an autoimmune disorder. Autoimmune disorders occur when the immune system attacks the body's own tissues and organs. In people with vitiligo the immune system appears to attack the pigment cells (melanocytes) in the skin. About 15 to 25 percent of people with vitiligo are also affected by at least one other autoimmune disorder, particularly autoimmune thyroid disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, Addison disease, or systemic lupus erythematosus.In the absence of other autoimmune conditions, vitiligo does not affect general health or physical functioning. However, concerns about appearance and ethnic identity are significant issues for many affected individuals.
[from GHR]

MedGen UID:
22677
Concept ID:
C0042900
Disease or Syndrome
3.

Vitiligo

MedGen UID:
504695
Concept ID:
CN000980
Finding
4.

Vitiligo-associated multiple autoimmune disease susceptibility 1

Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases. It is a genetically complex disorder involving multiple susceptibility genes and unknown environmental triggers. Patients with generalized vitiligo have elevated frequencies of other autoimmune diseases, suggesting that these diseases involve shared genetic components (summary by Jin et al., 2010). Genetic Heterogeneity of Vitiligo-Associated Multiple Autoimmune Disease Susceptibility Additional forms of vitiligo-associated multiple autoimmune disease susceptibility have been mapped to chromosomes 1p31 (VAMAS2, 607836, associated with mutation in the FOXD3 gene, 611539), 7 (VAMAS3; 608391), 8 (VAMAS4; 608392), 4 (VAMAS5; 609400), and 6p21.3 (VAMAS6; 193200). [from OMIM]

MedGen UID:
335788
Concept ID:
C1847835
Disease or Syndrome; Finding
5.

Embeline

MedGen UID:
233092
Concept ID:
C1330246
Organic Chemical; Pharmacologic Substance
6.

Clobex

MedGen UID:
230985
Concept ID:
C1330150
Organic Chemical; Pharmacologic Substance
7.

Dermovate

MedGen UID:
196472
Concept ID:
C0731514
Organic Chemical; Pharmacologic Substance; Steroid
8.

Cormax

MedGen UID:
196241
Concept ID:
C0719514
Organic Chemical; Pharmacologic Substance; Steroid
9.

Olux

MedGen UID:
181716
Concept ID:
C0939416
Organic Chemical; Pharmacologic Substance; Steroid
10.

Temovate

MedGen UID:
87792
Concept ID:
C0376978
Organic Chemical; Pharmacologic Substance; Steroid
11.

Clobetasol

A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression. [from MeSH]

MedGen UID:
40337
Concept ID:
C0008992
Organic Chemical; Pharmacologic Substance; Steroid
12.

Clobetasol propionate

This is the form in trademark preparations. [from MeSH]

MedGen UID:
28409
Concept ID:
C0055895
Organic Chemical; Pharmacologic Substance; Steroid
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