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Respiratory tract infection

MedGen UID:
11199
Concept ID:
C0035243
Disease or Syndrome
Synonyms: Respiratory infection; Respiratory infections
SNOMED CT: Respiratory tract infection (275498002); RTI - Respiratory tract infection (275498002)
 
HPO: HP:0011947

Definition

Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRespiratory tract infection

Conditions with this feature

Andermann syndrome
MedGen UID:
162893
Concept ID:
C0795950
Disease or Syndrome
Hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC), a neurodevelopmental and neurodegenerative disorder, is characterized by severe progressive sensorimotor neuropathy with resulting hypotonia, areflexia, and amyotrophy and variable degrees of dysgenesis of the corpus callosum. Mild-to-severe intellectual disability and "psychotic episodes" during adolescence are observed. Sensory modalities are moderately to severely affected beginning in infancy. The average age of onset of walking is 3.8 years; the average age of loss of walking is 13.8 years; the average age of death is 33 years.
Peroxisome biogenesis disorder 11B
MedGen UID:
766915
Concept ID:
C3554001
Disease or Syndrome
The overlapping phenotypes of neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease (IRD) represent the milder manifestations of the Zellweger syndrome spectrum (ZSS) of peroxisome biogenesis disorders. The clinical course of patients with the NALD and IRD presentation is variable and may include developmental delay, hypotonia, liver dysfunction, sensorineural hearing loss, retinal dystrophy, and visual impairment. Children with the NALD presentation may reach their teens, and those with the IRD presentation may reach adulthood (summary by Waterham and Ebberink, 2012). For a complete phenotypic description and a discussion of genetic heterogeneity of PBD(NALD/IRD), see 601539. Individuals with mutations in the PEX13 gene have cells of complementation group 13 (CG13, equivalent to CGH). For information on the history of PBD complementation groups, see 214100.
Immunodeficiency 15
MedGen UID:
816373
Concept ID:
C3810043
Disease or Syndrome
Immunodeficiency-15 (IMD15) is an autosomal recessive primary immunodeficiency disorder characterized by onset in infancy of life-threatening bacterial, fungal, and viral infections and failure to thrive. Laboratory studies show hypo- or agammaglobulinemia with relatively normal numbers of B and T cells. However, functional studies show impaired differentiation and activation of immune cells (summary by Pannicke et al., 2013).

Recent clinical studies

Etiology

Mazur NI, Bont L, Cohen AL, Cohen C, von Gottberg A, Groome MJ, Hellferscee O, Klipstein-Grobusch K, Mekgoe O, Naby F, Moyes J, Tempia S, Treurnicht FK, Venter M, Walaza S, Wolter N, Madhi SA; South African Severe Acute Respiratory Illness (SARI) Surveillance Group.
Clin Infect Dis 2017 Feb 15;64(4):443-450. doi: 10.1093/cid/ciw756. PMID: 27927871
Lu H, Zhang L, Huang H
Afr Health Sci 2015 Dec;15(4):1295-301. doi: 10.4314/ahs.v15i4.32. PMID: 26958034Free PMC Article
Vandepitte WP, Ponthong R, Srisarang S
J Med Assoc Thai 2015 Oct;98(10):974-84. PMID: 26638589
Chen ZR, Mize M, Wang YQ, Yan YD, Zhu CH, Wang Y, Ji W
J Med Virol 2014 Dec;86(12):2154-62. Epub 2014 Apr 30 doi: 10.1002/jmv.23952. PMID: 24782248
Little P, Stuart B, Moore M, Coenen S, Butler CC, Godycki-Cwirko M, Mierzecki A, Chlabicz S, Torres A, Almirall J, Davies M, Schaberg T, Mölstad S, Blasi F, De Sutter A, Kersnik J, Hupkova H, Touboul P, Hood K, Mullee M, O'Reilly G, Brugman C, Goossens H, Verheij T; GRACE consortium.
Lancet Infect Dis 2013 Feb;13(2):123-9. Epub 2012 Dec 19 doi: 10.1016/S1473-3099(12)70300-6. PMID: 23265995

Diagnosis

Mazur NI, Bont L, Cohen AL, Cohen C, von Gottberg A, Groome MJ, Hellferscee O, Klipstein-Grobusch K, Mekgoe O, Naby F, Moyes J, Tempia S, Treurnicht FK, Venter M, Walaza S, Wolter N, Madhi SA; South African Severe Acute Respiratory Illness (SARI) Surveillance Group.
Clin Infect Dis 2017 Feb 15;64(4):443-450. doi: 10.1093/cid/ciw756. PMID: 27927871
Lai K, Lin L, Liu B, Chen R, Tang Y, Luo W, Chen Q
Respirology 2016 May;21(4):683-8. Epub 2016 Mar 10 doi: 10.1111/resp.12748. PMID: 26969485
Vandepitte WP, Ponthong R, Srisarang S
J Med Assoc Thai 2015 Oct;98(10):974-84. PMID: 26638589
van Vugt SF, Broekhuizen BD, Zuithoff NP, van Essen GA, Ebell MH, Coenen S, Ieven M, Lammens C, Goossens H, Butler CC, Hood K, Little P, Verheij TJ; GRACE Consortium.
Fam Pract 2015 Aug;32(4):408-14. Epub 2015 Jun 4 doi: 10.1093/fampra/cmv039. PMID: 26045544
Yamamoto Y, Ohmichi M, Watanabe A, Niki Y, Aoki N, Kawai S, Chida K, Mikasa K, Seki M, Ishida T, Kadota J, Matsuse H, Fujita J, Kohno S
Jpn J Antibiot 2014 Aug;67(4):223-32. PMID: 25420318

Therapy

Ito F, Ohno Y, Toyoshi S, Kaito D, Koumei Y, Endo J, Kamamiya F, Mori H, Mori M, Morishita M, Funaguchi N, Minatoguchi S
Ther Adv Respir Dis 2016 Feb;10(1):34-42. Epub 2015 Dec 11 doi: 10.1177/1753465815620338. PMID: 26660898
Vandepitte WP, Ponthong R, Srisarang S
J Med Assoc Thai 2015 Oct;98(10):974-84. PMID: 26638589
Ruopp M, Chiswell K, Thaden JT, Merchant K, Tsalik EL
Ann Am Thorac Soc 2015 Dec;12(12):1852-63. doi: 10.1513/AnnalsATS.201505-291OC. PMID: 26360527
Duijker G, Bertsias A, Symvoulakis EK, Moschandreas J, Malliaraki N, Derdas SP, Tsikalas GK, Katerinopoulos HE, Pirintsos SA, Sourvinos G, Castanas E, Lionis C
J Ethnopharmacol 2015 Apr 2;163:157-66. Epub 2015 Jan 30 doi: 10.1016/j.jep.2015.01.030. PMID: 25645191
Little P, Stuart B, Moore M, Coenen S, Butler CC, Godycki-Cwirko M, Mierzecki A, Chlabicz S, Torres A, Almirall J, Davies M, Schaberg T, Mölstad S, Blasi F, De Sutter A, Kersnik J, Hupkova H, Touboul P, Hood K, Mullee M, O'Reilly G, Brugman C, Goossens H, Verheij T; GRACE consortium.
Lancet Infect Dis 2013 Feb;13(2):123-9. Epub 2012 Dec 19 doi: 10.1016/S1473-3099(12)70300-6. PMID: 23265995

Prognosis

Relster MM, Holm A, Pedersen C
APMIS 2017 Feb;125(2):148-156. Epub 2016 Nov 16 doi: 10.1111/apm.12636. PMID: 27859623
van Vugt SF, Broekhuizen BD, Zuithoff NP, van Essen GA, Ebell MH, Coenen S, Ieven M, Lammens C, Goossens H, Butler CC, Hood K, Little P, Verheij TJ; GRACE Consortium.
Fam Pract 2015 Aug;32(4):408-14. Epub 2015 Jun 4 doi: 10.1093/fampra/cmv039. PMID: 26045544
Chen ZR, Mize M, Wang YQ, Yan YD, Zhu CH, Wang Y, Ji W
J Med Virol 2014 Dec;86(12):2154-62. Epub 2014 Apr 30 doi: 10.1002/jmv.23952. PMID: 24782248
Lu MP, Ma LY, Zheng Q, Dong LL, Chen ZM
World J Pediatr 2013 Nov;9(4):346-9. Epub 2013 Nov 14 doi: 10.1007/s12519-013-0431-3. PMID: 24235068
Kim CK, Callaway Z, Choung JT, Yu JH, Shim KS, Kwon EM, Koh YY
Pediatr Int 2013 Aug;55(4):443-9. doi: 10.1111/ped.12125. PMID: 23659181

Clinical prediction guides

Pilloux L, LeRoy D, Brunel C, Roger T, Greub G
PLoS One 2016;11(3):e0150909. Epub 2016 Mar 7 doi: 10.1371/journal.pone.0150909. PMID: 26950066Free PMC Article
Vandepitte WP, Ponthong R, Srisarang S
J Med Assoc Thai 2015 Oct;98(10):974-84. PMID: 26638589
van Vugt SF, Broekhuizen BD, Zuithoff NP, van Essen GA, Ebell MH, Coenen S, Ieven M, Lammens C, Goossens H, Butler CC, Hood K, Little P, Verheij TJ; GRACE Consortium.
Fam Pract 2015 Aug;32(4):408-14. Epub 2015 Jun 4 doi: 10.1093/fampra/cmv039. PMID: 26045544
Duijker G, Bertsias A, Symvoulakis EK, Moschandreas J, Malliaraki N, Derdas SP, Tsikalas GK, Katerinopoulos HE, Pirintsos SA, Sourvinos G, Castanas E, Lionis C
J Ethnopharmacol 2015 Apr 2;163:157-66. Epub 2015 Jan 30 doi: 10.1016/j.jep.2015.01.030. PMID: 25645191
Chen ZR, Mize M, Wang YQ, Yan YD, Zhu CH, Wang Y, Ji W
J Med Virol 2014 Dec;86(12):2154-62. Epub 2014 Apr 30 doi: 10.1002/jmv.23952. PMID: 24782248

Recent systematic reviews

Harris AM, Hicks LA, Qaseem A; High Value Care Task Force of the American College of Physicians and for the Centers for Disease Control and Prevention.
Ann Intern Med 2016 Mar 15;164(6):425-34. Epub 2016 Jan 19 doi: 10.7326/M15-1840. PMID: 26785402
Ruopp M, Chiswell K, Thaden JT, Merchant K, Tsalik EL
Ann Am Thorac Soc 2015 Dec;12(12):1852-63. doi: 10.1513/AnnalsATS.201505-291OC. PMID: 26360527
Mao S, Zhang A, Huang S
Scand J Clin Lab Invest 2014 Oct;74(7):561-7. Epub 2014 May 30 doi: 10.3109/00365513.2014.921323. PMID: 24874085
Warren-Gash C, Fragaszy E, Hayward AC
Influenza Other Respir Viruses 2013 Sep;7(5):738-49. Epub 2012 Oct 8 doi: 10.1111/irv.12015. PMID: 23043518
Singh S, Loke YK, Furberg CD
Thorax 2011 May;66(5):383-8. Epub 2011 Feb 15 doi: 10.1136/thx.2010.152777. PMID: 21325145

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