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Items: 1 to 20 of 43

1.

Sporadic

Cases of the disease in question occur without a previous family history, i.e., as isolated cases without being transmitted from a parent and without other siblings being affected. [from HPO]

MedGen UID:
342827
Concept ID:
C1853237
Finding
2.

Alzheimer disease

Alzheimer disease (AD) is characterized by dementia that typically begins with subtle and poorly recognized failure of memory and slowly becomes more severe and, eventually, incapacitating. Other common findings include confusion, poor judgment, language disturbance, agitation, withdrawal, and hallucinations. Occasionally, seizures, Parkinsonian features, increased muscle tone, myoclonus, incontinence, and mutism occur. Death usually results from general inanition, malnutrition, and pneumonia. The typical clinical duration of the disease is eight to ten years, with a range from one to 25 years. Approximately 25% of all AD is familial (i.e., =2 persons in a family have AD) of which approximately 95% is late onset (age >60-65 years) and 5% is early onset (age <65 years). [from OMIM]

MedGen UID:
1853
Concept ID:
C0002395
Disease or Syndrome
3.

Sedentary lifestyle

A type of lifestyle that lacks physical exercise, characterized by sitting, reading, watching television or using a computer for much of the day without vigorous physical exertion. [from NCI]

MedGen UID:
280655
Concept ID:
C1532253
Finding
4.

Risk factor

An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, on the basis of epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. [from MeSH]

MedGen UID:
48477
Concept ID:
C0035648
Finding
5.

Insulin resistance

MedGen UID:
43904
Concept ID:
C0021655
Pathologic Function
6.

Obesity

MedGen UID:
18127
Concept ID:
C0028754
Disease or Syndrome
7.

Hypertension

MedGen UID:
6969
Concept ID:
C0020538
Disease or Syndrome
8.

Regular insulin

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). [from MeSH]

MedGen UID:
5827
Concept ID:
C0021641
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
9.

Hypercholesterolaemia

MedGen UID:
5687
Concept ID:
C0020443
Disease or Syndrome
10.

Able

MedGen UID:
721424
Concept ID:
C1299581
Finding
11.

Primary hypercholesterolemia

MedGen UID:
575264
Concept ID:
C0342879
Disease or Syndrome
12.

Insulin resistance

MedGen UID:
504630
Concept ID:
CN000801
Finding
13.

Obesity

MedGen UID:
368429
Concept ID:
C1963185
Finding
14.

Hypercholesterolemia

MedGen UID:
312004
Concept ID:
C1522133
Finding
15.

Family history

MedGen UID:
69143
Concept ID:
C0241889
Finding
16.

Neurodegeneration

MedGen UID:
17999
Concept ID:
C0027746
Cell or Molecular Dysfunction
17.

Neurocognitive disorder

A disorder characterised by a decline primarily in intellectual function due to disease of the brain caused by a variety of acquired conditions such as cerebrovascular disease, Alzheimer's disease, infections, adverse drug reactions and trauma. [from SNOMEDCT_US]

MedGen UID:
873945
Concept ID:
C4041080
Mental or Behavioral Dysfunction
18.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
19.

Disease Attributes

Clinical characteristics of disease or illness. [from MeSH]

MedGen UID:
199876
Concept ID:
C0752357
Disease or Syndrome
20.

Tauopathy

MedGen UID:
181880
Concept ID:
C0949664
Disease or Syndrome
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