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Items: 15

1.

Norepinephrine

A naturally occurring catecholamine hormone that functions as a neurotransmitter in the sympathetic nervous system. Norepinephrine directly stimulates adrenergic receptors. Stimulation of alpha-adrenergic receptors causes vasoconstriction of the radial smooth muscle of the iris, arteries, arterioles, veins, urinary bladder, and the sphincter of the gastrointestinal tract. Stimulation of beta-1 adrenergic receptors causes an increase in myocardial contractility, heart rate, automaticity, and atrioventricular (AV) conduction while stimulation of beta-2 adrenergic receptors causes bronchiolar and vascular smooth muscle dilatation. [from NCI]

MedGen UID:
45125
Concept ID:
C0028351
Hormone; Organic Chemical; Pharmacologic Substance
2.

Gait type

A pattern or manner of running, walking, or moving on foot. [from NCI]

MedGen UID:
42128
Concept ID:
C0016928
Finding
3.

Dopamine

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
4.

Hypoplasia

Incomplete or underdevelopment of a tissue or organ. [from NCI]

MedGen UID:
537146
Concept ID:
C0243069
Pathologic Function
5.

Resonance

MedGen UID:
534094
Concept ID:
C0231881
Finding
6.

Moderate

Having a medium degree of severity. For quantitative traits, a deviation of between three and four standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
525853
Concept ID:
C0205081
Qualitative Concept
7.

Ability to balance

The maintenance of a stable, upright body position. [from NCI]

MedGen UID:
154340
Concept ID:
C0560184
Finding
8.

Steppage gait

An abnormal gait pattern that arises from weakness of the pretibial and peroneal muscles due to a lower motor neuron lesion. Affected patients have footdrop and are unable to dorsiflex and evert the foot. The leg is lifted high on walking so that the toes clear the ground, and there may be a slapping noise when the foot strikes the ground again. [from HPO]

MedGen UID:
98105
Concept ID:
C0427149
Finding
9.

Waddling gait

MedGen UID:
66667
Concept ID:
C0231712
Finding; Sign or Symptom
10.

Abnormal

Deviating in any way from the state, position, structure, condition, behavior, or rule which is considered a norm. [from NCI]

MedGen UID:
59964
Concept ID:
C0205161
Finding
11.

Imaging of central nervous system abnormal

MedGen UID:
929793
Concept ID:
C4304124
Finding
12.

Imaging of brain abnormal

MedGen UID:
751376
Concept ID:
C2711610
Finding
13.

Magnetic resonance imaging of brain abnormal

MedGen UID:
728567
Concept ID:
C1319851
Finding
14.

Abnormal norepinephrine

MedGen UID:
678504
Concept ID:
C0853422
Finding
15.

MRI scan abnormal

MedGen UID:
612538
Concept ID:
C0436540
Finding
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