Format

Send to:

Choose Destination

Links from PubMed

Ventricular arrhythmia

MedGen UID:
39082
Concept ID:
C0085612
Disease or Syndrome; Finding
Synonyms: Ventricular arrhythmias
SNOMED CT: Ventricular arrhythmia (44103008)
 
HPO: HP:0004308

Definition

A disorder characterized by an electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles. [from NCI]

Conditions with this feature

Kasabach-Merritt syndrome
MedGen UID:
65122
Concept ID:
C0221025
Disease or Syndrome
A cavernous angiomatosis associated with the destruction of platelets, resulting in thrombocytopenia.
Dilated cardiomyopathy 1A
MedGen UID:
258500
Concept ID:
C1449563
Disease or Syndrome
LMNA-related dilated cardiomyopathy (DCM) is caused by pathogenic variants in LMNA and is characterized by left ventricular enlargement and/or reduced systolic function preceded or accompanied by significant conduction system disease and/or arrhythmias. LMNA-related DCM usually presents in early to mid-adulthood with symptomatic conduction system disease or arrhythmias, or with symptomatic DCM including heart failure or embolus from a left ventricular mural thrombus. Sudden cardiac death can occur, and in some instances is the presenting manifestation; sudden cardiac death may occur with minimal or no systolic dysfunction.
Arrhythmogenic right ventricular dysplasia, familial, 2
MedGen UID:
318748
Concept ID:
C1832931
Disease or Syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC) – previously referred to as arrhythmogenic right ventricular dysplasia (ARVD) – is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle, and it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Dilated cardiomyopathy 1P
MedGen UID:
322782
Concept ID:
C1835928
Disease or Syndrome
Nonsyndromic isolated dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and systolic dysfunction, a reduction in the myocardial force of contraction. DCM usually presents with any one of the following: Heart failure with symptoms of congestion (edema, orthopnea, paroxysmal nocturnal dyspnea) and/or reduced cardiac output (fatigue, dyspnea on exertion). Arrhythmias and/or conduction system disease. Thromboembolic disease (from left ventricular mural thrombus) including stroke.
Arrhythmogenic right ventricular cardiomyopathy, type 9
MedGen UID:
373205
Concept ID:
C1836906
Disease or Syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC) – previously referred to as arrhythmogenic right ventricular dysplasia (ARVD) – is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle, and it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Left ventricular noncompaction 1
MedGen UID:
349005
Concept ID:
C1858725
Disease or Syndrome
Left ventricular noncompaction (LVNC) is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle (Sasse-Klaassen et al., 2004). The mechanistic basis is thought to be an intrauterine arrest of myocardial development with lack of compaction of the loose myocardial meshwork. LVNC may occur in isolation or in association with congenital heart disease. Distinctive morphologic features can be recognized on 2-dimensional echocardiography (Kurosaki et al., 1999). Noncompaction of the ventricular myocardium is sometimes referred to as spongy myocardium. Stollberger et al. (2002) commented that the term 'isolated LVNC,' meaning LVNC without coexisting cardiac abnormalities, is misleading, because additional cardiac abnormalities are found in nearly all patients with LVNC. Genetic Heterogeneity of Left Ventricular Noncompaction A locus for autosomal dominant left ventricular noncompaction has been identified on chromosome 11p15 (LVNC2; 609470). LVNC3 (see 605906) is caused by mutation in the LDB3 gene (605906) on chromosome 10q23. LVNC4 (see 613424) is caused by mutation in the ACTC1 gene (102540) on chromosome 15q14. LVNC5 (see 613426) is caused by mutation in the MYH7 gene (160760) on chromosome 14q12. LVNC6 (see 601494) is caused by mutation in the TNNT2 gene (191045) on chromosome 1q32. LVNC7 (615092) is caused by mutation in the MIB1 gene (608677) on chromosome 18q11. LVNC8 (615373) is caused by mutation in the PRDM16 gene (605557) on chromosome 1p36. LVNC9 (see 611878) is caused by mutation in the TPM1 gene (191010) on chromosome 15q22. LVNC10 (615396) is caused by mutation in the MYBPC3 gene (600958) on chromosome 11p11. LVNC can also occur as part of an X-linked disorder, Barth syndrome (302060), caused by mutation in the TAZ gene (300394) on chromosome Xq28.
Arrhythmogenic right ventricular dysplasia, familial 1
MedGen UID:
349530
Concept ID:
C1862511
Disease or Syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC) – previously referred to as arrhythmogenic right ventricular dysplasia (ARVD) – is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle, and it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Arrhythmogenic right ventricular cardiomyopathy, type 11
MedGen UID:
351237
Concept ID:
C1864850
Disease or Syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC) – previously referred to as arrhythmogenic right ventricular dysplasia (ARVD) – is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle, and it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Arrhythmogenic right ventricular dysplasia, familial, 4
MedGen UID:
356107
Concept ID:
C1865881
Disease or Syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC) – previously referred to as arrhythmogenic right ventricular dysplasia (ARVD) – is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle, and it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Arrhythmogenic right ventricular dysplasia, familial, 3
MedGen UID:
356108
Concept ID:
C1865882
Disease or Syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC) – previously referred to as arrhythmogenic right ventricular dysplasia (ARVD) – is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle, and it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Arrhythmogenic right ventricular cardiomyopathy, type 12
MedGen UID:
409749
Concept ID:
C1969081
Disease or Syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC) – previously referred to as arrhythmogenic right ventricular dysplasia (ARVD) – is characterized by progressive fibrofatty replacement of the myocardium that predisposes to ventricular tachycardia and sudden death in young individuals and athletes. It primarily affects the right ventricle, and it may also involve the left ventricle. The presentation of disease is highly variable even within families, and some affected individuals may not meet established clinical criteria. The mean age at diagnosis is 31 years (±13; range: 4-64 years).
Brugada syndrome 3
MedGen UID:
395633
Concept ID:
C2678478
Disease or Syndrome
Brugada syndrome is characterized by cardiac conduction abnormalities (ST-segment abnormalities in leads V1-V3 on ECG and a high risk for ventricular arrhythmias) that can result in sudden death. Brugada syndrome presents primarily during adulthood although age at diagnosis may range from infancy to late adulthood. The mean age of sudden death is approximately 40 years. Clinical presentations may also include sudden infant death syndrome (SIDS; death of a child during the first year of life without an identifiable cause) and the sudden unexpected nocturnal death syndrome (SUNDS), a typical presentation in individuals from Southeast Asia. Other conduction defects can include first-degree AV block, intraventricular conduction delay, right bundle branch block, and sick sinus syndrome.
Long QT syndrome 9
MedGen UID:
395635
Concept ID:
C2678485
Disease or Syndrome
Long QT syndrome (LQTS) is a cardiac electrophysiologic disorder, characterized by QT prolongation and T-wave abnormalities on the ECG that are associated with tachyarrhythmias, typically the ventricular tachycardia torsade de pointes (TdP). TdP is usually self-terminating, thus causing a syncopal event, the most common symptom in individuals with LQTS. Such cardiac events typically occur during exercise and emotional stress, less frequently during sleep, and usually without warning. In some instances, TdP degenerates to ventricular fibrillation and causes aborted cardiac arrest (if the individual is defibrillated) or sudden death. Approximately 50% of untreated individuals with a pathogenic variant in one of the genes associated with LQTS have symptoms, usually one to a few syncopal events. While cardiac events may occur from infancy through middle age, they are most common from the preteen years through the 20s. Some types of LQTS are associated with a phenotype extending beyond cardiac arrhythmia. In addition to the prolonged QT interval, associations include muscle weakness and facial dysmorphism in Andersen-Tawil syndrome (LQTS type 7), hand/foot, facial, and neurodevelopmental features in Timothy syndrome (LQTS type 8), and profound sensorineural hearing loss in Jervell and Lange-Nielson syndrome.
Glycogen storage disease XV
MedGen UID:
462104
Concept ID:
C3150754
Disease or Syndrome

Recent clinical studies

Etiology

Trifirò G, de Ridder M, Sultana J, Oteri A, Rijnbeek P, Pecchioli S, Mazzaglia G, Bezemer I, Garbe E, Schink T, Poluzzi E, Frøslev T, Molokhia M, Diemberger I, Sturkenboom MCJM
CMAJ 2017 Apr 18;189(15):E560-E568. doi: 10.1503/cmaj.160355. PMID: 28420680Free PMC Article
Qirjazi E, McArthur E, Nash DM, Dixon SN, Weir MA, Vasudev A, Jandoc R, Gula LJ, Oliver MJ, Wald R, Garg AX
PLoS One 2016;11(8):e0160768. Epub 2016 Aug 11 doi: 10.1371/journal.pone.0160768. PMID: 27513855Free PMC Article
Smolina K, Mintzes B, Hanley GE, Oberlander TF, Morgan SG
Pharmacoepidemiol Drug Saf 2016 Oct;25(10):1210-1214. Epub 2016 Jun 14 doi: 10.1002/pds.4035. PMID: 27296864
Feng T, Zhang S, Chen K, Hua W, Ren X
J Mater Sci Mater Med 2015 Oct;26(10):240. Epub 2015 Sep 28 doi: 10.1007/s10856-015-5575-3. PMID: 26411436
Chen HL, Hsiao FY
Pharmacoepidemiol Drug Saf 2015 Aug;24(8):841-8. Epub 2015 Jun 22 doi: 10.1002/pds.3814. PMID: 26098410

Diagnosis

Qirjazi E, McArthur E, Nash DM, Dixon SN, Weir MA, Vasudev A, Jandoc R, Gula LJ, Oliver MJ, Wald R, Garg AX
PLoS One 2016;11(8):e0160768. Epub 2016 Aug 11 doi: 10.1371/journal.pone.0160768. PMID: 27513855Free PMC Article
Feng T, Zhang S, Chen K, Hua W, Ren X
J Mater Sci Mater Med 2015 Oct;26(10):240. Epub 2015 Sep 28 doi: 10.1007/s10856-015-5575-3. PMID: 26411436
Hou PN, Tsai SC, Lin WY, Cheng CM, Chiang KF, Chang YC, Huang JL, Hung GU, Chen SA, Chen J
Ann Nucl Med 2015 Nov;29(9):772-8. Epub 2015 Jul 21 doi: 10.1007/s12149-015-1007-1. PMID: 26194143
Chen HL, Hsiao FY
Pharmacoepidemiol Drug Saf 2015 Aug;24(8):841-8. Epub 2015 Jun 22 doi: 10.1002/pds.3814. PMID: 26098410
Kido K, Brouse SD, Macaulay TE, Charnigo RJ, Anaya P
Curr Drug Saf 2015;10(3):227-33. PMID: 25921410

Therapy

Trifirò G, de Ridder M, Sultana J, Oteri A, Rijnbeek P, Pecchioli S, Mazzaglia G, Bezemer I, Garbe E, Schink T, Poluzzi E, Frøslev T, Molokhia M, Diemberger I, Sturkenboom MCJM
CMAJ 2017 Apr 18;189(15):E560-E568. doi: 10.1503/cmaj.160355. PMID: 28420680Free PMC Article
Qirjazi E, McArthur E, Nash DM, Dixon SN, Weir MA, Vasudev A, Jandoc R, Gula LJ, Oliver MJ, Wald R, Garg AX
PLoS One 2016;11(8):e0160768. Epub 2016 Aug 11 doi: 10.1371/journal.pone.0160768. PMID: 27513855Free PMC Article
Smolina K, Mintzes B, Hanley GE, Oberlander TF, Morgan SG
Pharmacoepidemiol Drug Saf 2016 Oct;25(10):1210-1214. Epub 2016 Jun 14 doi: 10.1002/pds.4035. PMID: 27296864
Feng T, Zhang S, Chen K, Hua W, Ren X
J Mater Sci Mater Med 2015 Oct;26(10):240. Epub 2015 Sep 28 doi: 10.1007/s10856-015-5575-3. PMID: 26411436
Chen HL, Hsiao FY
Pharmacoepidemiol Drug Saf 2015 Aug;24(8):841-8. Epub 2015 Jun 22 doi: 10.1002/pds.3814. PMID: 26098410

Prognosis

Styles K, Sapp J Jr, Gardner M, Gray C, Abdelwahab A, MacIntyre C, Gao D, Al-Harbi M, Doucette S, Theriault C, Parkash R
Int J Cardiol 2017 Oct 1;244:169-174. Epub 2017 Jun 13 doi: 10.1016/j.ijcard.2017.06.041. PMID: 28634036
Kalla M, Herring N, Paterson DJ
Auton Neurosci 2016 Aug;199:29-37. Epub 2016 Aug 26 doi: 10.1016/j.autneu.2016.08.016. PMID: 27590099Free PMC Article
Feng T, Zhang S, Chen K, Hua W, Ren X
J Mater Sci Mater Med 2015 Oct;26(10):240. Epub 2015 Sep 28 doi: 10.1007/s10856-015-5575-3. PMID: 26411436
Hou PN, Tsai SC, Lin WY, Cheng CM, Chiang KF, Chang YC, Huang JL, Hung GU, Chen SA, Chen J
Ann Nucl Med 2015 Nov;29(9):772-8. Epub 2015 Jul 21 doi: 10.1007/s12149-015-1007-1. PMID: 26194143
Chen Z, Sohal M, Voigt T, Sammut E, Tobon-Gomez C, Child N, Jackson T, Shetty A, Bostock J, Cooklin M, O'Neill M, Wright M, Murgatroyd F, Gill J, Carr-White G, Chiribiri A, Schaeffter T, Razavi R, Rinaldi CA
Heart Rhythm 2015 Apr;12(4):792-801. Epub 2014 Dec 19 doi: 10.1016/j.hrthm.2014.12.020. PMID: 25533585

Clinical prediction guides

Trifirò G, de Ridder M, Sultana J, Oteri A, Rijnbeek P, Pecchioli S, Mazzaglia G, Bezemer I, Garbe E, Schink T, Poluzzi E, Frøslev T, Molokhia M, Diemberger I, Sturkenboom MCJM
CMAJ 2017 Apr 18;189(15):E560-E568. doi: 10.1503/cmaj.160355. PMID: 28420680Free PMC Article
Qirjazi E, McArthur E, Nash DM, Dixon SN, Weir MA, Vasudev A, Jandoc R, Gula LJ, Oliver MJ, Wald R, Garg AX
PLoS One 2016;11(8):e0160768. Epub 2016 Aug 11 doi: 10.1371/journal.pone.0160768. PMID: 27513855Free PMC Article
Feng T, Zhang S, Chen K, Hua W, Ren X
J Mater Sci Mater Med 2015 Oct;26(10):240. Epub 2015 Sep 28 doi: 10.1007/s10856-015-5575-3. PMID: 26411436
Hou PN, Tsai SC, Lin WY, Cheng CM, Chiang KF, Chang YC, Huang JL, Hung GU, Chen SA, Chen J
Ann Nucl Med 2015 Nov;29(9):772-8. Epub 2015 Jul 21 doi: 10.1007/s12149-015-1007-1. PMID: 26194143
Bonato FO, Lemos MM, Cassiolato JL, Canziani ME
PLoS One 2013;8(6):e66036. Epub 2013 Jun 7 doi: 10.1371/journal.pone.0066036. PMID: 23762460Free PMC Article

Recent systematic reviews

Khan SU, Winnicka L, Saleem MA, Rahman H, Rehman N
Heart Lung 2017 Nov - Dec;46(6):417-424. Epub 2017 Sep 27 doi: 10.1016/j.hrtlng.2017.09.001. PMID: 28958592
Leelakanok N, Holcombe A, Schweizer ML
Clin Drug Investig 2016 Feb;36(2):97-107. doi: 10.1007/s40261-015-0360-0. PMID: 26649742
Zuchinali P, Ribeiro PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE
Europace 2016 Feb;18(2):257-66. Epub 2015 Oct 5 doi: 10.1093/europace/euv261. PMID: 26443445
Nayyar S, Ganesan AN, Brooks AG, Sullivan T, Roberts-Thomson KC, Sanders P
Eur Heart J 2013 Feb;34(8):560-71. Epub 2012 Dec 21 doi: 10.1093/eurheartj/ehs453. PMID: 23264584
Wei J, Ni J, Huang D, Chen M, Yan S, Peng Y
Clin Cardiol 2010 Sep;33(9):572-7. doi: 10.1002/clc.20762. PMID: 20842742

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Medical Encyclopedia

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Support Center