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Items: 1 to 20 of 53

1.

Ursodiol

A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract. [from NCI]

MedGen UID:
21796
Concept ID:
C0042105
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
2.

gabazine

MedGen UID:
127793
Concept ID:
C0628385
Organic Chemical; Pharmacologic Substance
3.

AT 10

MedGen UID:
108470
Concept ID:
C0591126
Organic Chemical; Pharmacologic Substance
4.

Pregnenolone

A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. [from MeSH]

MedGen UID:
91192
Concept ID:
C0373704
Hormone; Organic Chemical; Pharmacologic Substance
5.

Retinal degeneration

A deterioration of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality. [from HPO]

MedGen UID:
48432
Concept ID:
C0035304
Finding; Pathologic Function
6.

Cholestasis

Impairment of bile flow due to obstruction in bile ducts. [from HPO]

MedGen UID:
925
Concept ID:
C0008370
Disease or Syndrome
7.

Triggered by

Something that sets into motion some course of events; a device that activates or releases or causes something to happen. [from NCI]

MedGen UID:
252950
Concept ID:
C1444748
Qualitative Concept
8.

Gallstone

Presence or formation of GALLSTONES in the GALLBLADDER. [from MeSH]

MedGen UID:
215268
Concept ID:
C0947622
Disease or Syndrome
9.

Disinhibition

A lack of restraint manifested in several ways, including disregard for social conventions, impulsivity, and poor risk assessment. [from HPO]

MedGen UID:
140859
Concept ID:
C0424296
Mental or Behavioral Dysfunction
10.

Retinaldehyde

A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration. [from MeSH]

MedGen UID:
19764
Concept ID:
C0035331
Organic Chemical; Pharmacologic Substance; Vitamin
11.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
12.

Degenerative abnormality

Disturbance of cell integrity and deterioration of normal tissue, cells or organs. [from NCI_CDISC]

MedGen UID:
3705
Concept ID:
C0011164
Pathologic Function
13.

Alzheimer disease

Alzheimer disease (AD) is characterized by dementia that typically begins with subtle and poorly recognized failure of memory and slowly becomes more severe and, eventually, incapacitating. Other common findings include confusion, poor judgment, language disturbance, agitation, withdrawal, and hallucinations. Occasionally, seizures, Parkinsonian features, increased muscle tone, myoclonus, incontinence, and mutism occur. Death usually results from general inanition, malnutrition, and pneumonia. The typical clinical duration of the disease is eight to ten years, with a range from one to 25 years. Approximately 25% of all AD is familial (i.e., =2 persons in a family have AD) of which approximately 95% is late onset (age >60-65 years) and 5% is early onset (age <65 years). [from GTR]

MedGen UID:
1853
Concept ID:
C0002395
Disease or Syndrome
14.

Antagonist, GABA-A Receptor

Drugs that bind to but do not activate GABA-A RECEPTORS thereby blocking the actions of endogenous or exogenous GABA-A RECEPTOR AGONISTS. [from MeSH]

MedGen UID:
445405
Concept ID:
C2936801
Pharmacologic Substance
15.

Cholit-Ursan

MedGen UID:
327745
Concept ID:
C1564355
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
16.

Ursolite

MedGen UID:
327744
Concept ID:
C1564350
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
17.

Cholofalk

MedGen UID:
288942
Concept ID:
C1564354
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
18.

Delursan

MedGen UID:
288941
Concept ID:
C1564353
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
19.

Ursobilane

MedGen UID:
288940
Concept ID:
C1564352
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
20.

Ursochol

MedGen UID:
288939
Concept ID:
C1564351
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
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