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Items: 2

1.

Protoporphyrin IX

A tetrapyrrole containing 4 methyl, 2 propionic and 2 vinyl side chains that is a metabolic precursor for hemes, cytochrome c and chlorophyll. Protoporphyrin IX is produced by oxidation of the methylene bridge of protoporphyrinogen by the enzyme protoporphyrinogen oxidase. [from NCI]

MedGen UID:
35031
Concept ID:
C0072497
Pharmacologic Substance
2.

Aminolevulinic Acid

A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42648&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42648&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C234" NCI Thesaurus) [from PDQ]

MedGen UID:
1472
Concept ID:
C0002563
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance

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