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Protoporphyrin IX

A tetrapyrrole containing 4 methyl, 2 propionic and 2 vinyl side chains that is a metabolic precursor for hemes, cytochrome c and chlorophyll. Protoporphyrin IX is produced by oxidation of the methylene bridge of protoporphyrinogen by the enzyme protoporphyrinogen oxidase. [from NCI]

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Concept ID:
Pharmacologic Substance

Aminolevulinic Acid

A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for "" active clinical trials or "" closed clinical trials using this agent. ("" NCI Thesaurus) [from PDQ]

MedGen UID:
Concept ID:
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance

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