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Items: 13

1.

Mental Depression

Depression is a serious medical illness. It's more than just a feeling of being sad or blue for a few days. If you are one of the more than 19 million teens and adults in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life. Symptoms can include. -Feeling sad or empty. -Loss of interest in favorite activities. -Overeating, or not wanting to eat at all. -Not being able to sleep, or sleeping too much. -Feeling very tired. -Feeling hopeless, irritable, anxious, or guilty. -Aches or pains, headaches, cramps, or digestive problems. -Thoughts of death or suicide. Depression is a disorder of the brain. There are a variety of causes, including genetic, biological, environmental, and psychological factors. Depression can happen at any age, but it often begins in teens and young adults. It is much more common in women. Women can also get postpartum depression after the birth of a baby. Some people get seasonal affective disorder in the winter. Depression is one part of bipolar disorder. There are effective treatments for depression, including antidepressants, talk therapy, or both. NIH: National Institute of Mental Health.  [from MedlinePlus]

MedGen UID:
8325
Concept ID:
C0011570
Mental or Behavioral Dysfunction
2.

Chronic kidney disease

You have two kidneys, each about the size of your fist. Their main job is to filter wastes and excess water out of your blood to make urine. They also keep the body's chemical balance, help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged and can't filter blood as they should. This damage can cause wastes to build up in your body. It can also cause other problems that can harm your health. Diabetes and high blood pressure are the most common causes of CKD. The kidney damage occurs slowly over many years. Many people don't have any symptoms until their kidney disease is very advanced. Blood and urine tests are the only way to know if you have kidney disease. Treatment may include medicines to lower blood pressure, control blood glucose, and lower blood cholesterol. CKD can get worse over time. CKD may lead to kidney failure. The only treatment options for kidney failure are dialysis or a kidney transplantation. You can take steps to keep your kidneys healthier longer:. -Choose foods with less salt (sodium). -Keep your blood pressure below 130/80. -Keep your blood glucose in the target range, if you have diabetes. NIH: National Institute of Diabetes and Digestive and Kidney Diseases.  [from MedlinePlus]

MedGen UID:
473458
Concept ID:
C1561643
Disease or Syndrome
3.

Chronic kidney disease

Functional anomaly of the kidney persisting for at least three months. [from HPO]

MedGen UID:
196667
Concept ID:
C0748318
Finding
4.

Depression

An emotional state characterized by feelings of sadness, emptiness, and/or tearfulness. [from NCI]

MedGen UID:
137999
Concept ID:
C0344315
Finding
5.

Chronic

Slow, creeping onset, slow progress and long continuance of disease manifestations. [from HPO]

MedGen UID:
104657
Concept ID:
C0205191
Temporal Concept
6.

Abnormality of the kidney

An abnormality of the kidney. [from HPO]

MedGen UID:
78593
Concept ID:
C0266292
Congenital Abnormality
7.

Nephropathy

You have two kidneys, each about the size of your fist. They are near the middle of your back, just below the rib cage. Inside each kidney there are about a million tiny structures called nephrons. They filter your blood. They remove wastes and extra water, which become urine. The urine flows through tubes called ureters. It goes to your bladder, which stores the urine until you go to the bathroom. Most kidney diseases attack the nephrons. This damage may leave kidneys unable to remove wastes. Causes can include genetic problems, injuries, or medicines. You have a higher risk of kidney disease if you have diabetes, high blood pressure, or a close family member with kidney disease. Chronic kidney disease damages the nephrons slowly over several years. Other kidney problems include. -Cancer. -Cysts. -Stones. -Infections. Your doctor can do blood and urine tests to check if you have kidney disease. If your kidneys fail, you will need dialysis or a kidney transplant. NIH: National Institute of Diabetes and Digestive and Kidney Diseases.  [from MedlinePlus]

MedGen UID:
9635
Concept ID:
C0022658
Disease or Syndrome
8.

Depression

A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure. [from HPO]

MedGen UID:
4229
Concept ID:
C0011581
Mental or Behavioral Dysfunction
9.

Desvenlafaxine

A synthetic phenethylamine bicyclic derivative with antidepressant activity. Desvenlafaxine is a selective reuptake inhibitor of serotonin and norepinephrine due to its high binding affinities to the pre-synaptic serotonin and norepinephrine transporters. By blocking both transporters, this agent prolongs neurotransmitter activities of both serotonin and norepinephrine, thereby alleviating depressive state. [from NCI]

MedGen UID:
363670
Concept ID:
C1880288
Organic Chemical; Pharmacologic Substance
10.

milnacipran

MedGen UID:
323468
Concept ID:
C1533126
Organic Chemical; Pharmacologic Substance
11.

reboxetine

MedGen UID:
63532
Concept ID:
C0168388
Organic Chemical; Pharmacologic Substance
12.

Tianeptine

MedGen UID:
37685
Concept ID:
C0076652
Organic Chemical; Pharmacologic Substance
13.

amitriptyline N-oxide

MedGen UID:
13828
Concept ID:
C0051694
Organic Chemical; Pharmacologic Substance
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