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Rivaroxaban

MedGen UID:
329288
Concept ID:
C1739768
Organic Chemical; Pharmacologic Substance
Synonyms: 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
SNOMED CT: Rivaroxaban (442031002); Rivaroxaban (442539005)
 

Definition

A morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM. It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRivaroxaban

Recent clinical studies

Etiology

Hong KS, Kwon SU, Lee SH, Lee JS, Kim YJ, Song TJ, Kim YD, Park MS, Kim EG, Cha JK, Sung SM, Yoon BW, Bang OY, Seo WK, Hwang YH, Ahn SH, Kang DW, Kang HG, Yu KH; Phase 2 Exploratory Clinical Study to Assess the Effects of Xarelto (Rivaroxaban) Versus Warfarin on Ischemia, Bleeding, and Hospital Stay in Acute Cerebral Infarction Patients With Non-valvular Atrial Fibrillation (Triple AXEL) Study Group.
JAMA Neurol 2017 Oct 1;74(10):1206-1215. doi: 10.1001/jamaneurol.2017.2161. PMID: 28892526
Barón-Esquivias G, Marín F, Sanmartín Fernandez M
Expert Rev Cardiovasc Ther 2017 May;15(5):403-413. Epub 2017 Mar 28 doi: 10.1080/14779072.2017.1309293. PMID: 28319424
Bai Y, Deng H, Shantsila A, Lip GY
Stroke 2017 Apr;48(4):970-976. Epub 2017 Feb 17 doi: 10.1161/STROKEAHA.116.016275. PMID: 28213573
Tao S, Otomo K, Ono Y, Osaka Y, Hirao T, Koura K, Manno T, Ueshima D, Shimizu S, Isobe M, Hirao K
J Interv Card Electrophysiol 2017 Mar;48(2):167-175. Epub 2016 Dec 9 doi: 10.1007/s10840-016-0214-6. PMID: 27943112
Somjen D, Sharfman ZT, Katzburg S, Sharon O, Maman E, Salai M, Stern N, Dolkart O
Connect Tissue Res 2017 Mar;58(2):215-220. Epub 2016 Aug 11 doi: 10.1080/03008207.2016.1220942. PMID: 27661794

Diagnosis

Wiesen MHJ, Blaich C, Streichert T, Michels G, Müller C
Clin Chem Lab Med 2017 Aug 28;55(9):1349-1359. doi: 10.1515/cclm-2016-0888. PMID: 28328524
Stöllberger C, Finsterer J
Neurol Neurochir Pol 2017 Mar - Apr;51(2):194-196. Epub 2017 Feb 3 doi: 10.1016/j.pjnns.2017.01.010. PMID: 28215696
Coleman CI, Baugh C, Crivera C, Milentijevic D, Wang SW, Lu L, Nelson WW
J Med Econ 2017 Feb;20(2):200-203. Epub 2016 Oct 26 doi: 10.1080/13696998.2016.1243544. PMID: 27780397
Margolis JM, Deitelzweig S, Kline J, Tran O, Smith DM, Crivera C, Bookhart B, Schein J
Clin Ther 2016 Nov;38(11):2496-2503. Epub 2016 Oct 15 doi: 10.1016/j.clinthera.2016.09.007. PMID: 27751675
Dault R, Vanasse A, Blais L, Perreault S, Farand P, Le Templier G, Beauchesne MF
Clin Appl Thromb Hemost 2016 Nov;22(8):765-771. Epub 2015 Oct 14 doi: 10.1177/1076029615611249. PMID: 26467323

Therapy

Hong KS, Kwon SU, Lee SH, Lee JS, Kim YJ, Song TJ, Kim YD, Park MS, Kim EG, Cha JK, Sung SM, Yoon BW, Bang OY, Seo WK, Hwang YH, Ahn SH, Kang DW, Kang HG, Yu KH; Phase 2 Exploratory Clinical Study to Assess the Effects of Xarelto (Rivaroxaban) Versus Warfarin on Ischemia, Bleeding, and Hospital Stay in Acute Cerebral Infarction Patients With Non-valvular Atrial Fibrillation (Triple AXEL) Study Group.
JAMA Neurol 2017 Oct 1;74(10):1206-1215. doi: 10.1001/jamaneurol.2017.2161. PMID: 28892526
Barón-Esquivias G, Marín F, Sanmartín Fernandez M
Expert Rev Cardiovasc Ther 2017 May;15(5):403-413. Epub 2017 Mar 28 doi: 10.1080/14779072.2017.1309293. PMID: 28319424
Helin TA, Virtanen L, Manninen M, Leskinen J, Leppilahti J, Joutsi-Korhonen L, Lassila R
J Thromb Thrombolysis 2017 May;43(4):562-569. doi: 10.1007/s11239-017-1492-2. PMID: 28315166
Bai Y, Deng H, Shantsila A, Lip GY
Stroke 2017 Apr;48(4):970-976. Epub 2017 Feb 17 doi: 10.1161/STROKEAHA.116.016275. PMID: 28213573
Tao S, Otomo K, Ono Y, Osaka Y, Hirao T, Koura K, Manno T, Ueshima D, Shimizu S, Isobe M, Hirao K
J Interv Card Electrophysiol 2017 Mar;48(2):167-175. Epub 2016 Dec 9 doi: 10.1007/s10840-016-0214-6. PMID: 27943112

Prognosis

Hong KS, Kwon SU, Lee SH, Lee JS, Kim YJ, Song TJ, Kim YD, Park MS, Kim EG, Cha JK, Sung SM, Yoon BW, Bang OY, Seo WK, Hwang YH, Ahn SH, Kang DW, Kang HG, Yu KH; Phase 2 Exploratory Clinical Study to Assess the Effects of Xarelto (Rivaroxaban) Versus Warfarin on Ischemia, Bleeding, and Hospital Stay in Acute Cerebral Infarction Patients With Non-valvular Atrial Fibrillation (Triple AXEL) Study Group.
JAMA Neurol 2017 Oct 1;74(10):1206-1215. doi: 10.1001/jamaneurol.2017.2161. PMID: 28892526
Seki K, Mizuno Y, Sakashita T, Nakano S, Tanno J, Okazaki Y, Muramatsu T, Nishimura S, Senbonmatsu T
J Pharmacol Sci 2017 Mar;133(3):156-161. Epub 2017 Feb 24 doi: 10.1016/j.jphs.2017.02.010. PMID: 28314697
Bundhun PK, Soogund MZ, Teeluck AR, Pursun M, Bhurtu A, Huang WQ
BMC Cardiovasc Disord 2017 Jan 6;17(1):15. doi: 10.1186/s12872-016-0449-2. PMID: 28056795Free PMC Article
Enriquez AD, Churchill T, Gautam S, Chinitz JS, Barbhaiya CR, Kumar S, John RM, Tedrow UB, Koplan BA, Stevenson WG, Michaud GF
Pacing Clin Electrophysiol 2017 Feb;40(2):183-190. doi: 10.1111/pace.13013. PMID: 28054374
Mantha S, Laube E, Miao Y, Sarasohn DM, Parameswaran R, Stefanik S, Brar G, Samedy P, Wills J, Harnicar S, Soff GA
J Thromb Thrombolysis 2017 Feb;43(2):166-171. doi: 10.1007/s11239-016-1429-1. PMID: 27696084Free PMC Article

Clinical prediction guides

Barón-Esquivias G, Marín F, Sanmartín Fernandez M
Expert Rev Cardiovasc Ther 2017 May;15(5):403-413. Epub 2017 Mar 28 doi: 10.1080/14779072.2017.1309293. PMID: 28319424
Bai Y, Deng H, Shantsila A, Lip GY
Stroke 2017 Apr;48(4):970-976. Epub 2017 Feb 17 doi: 10.1161/STROKEAHA.116.016275. PMID: 28213573
Enriquez AD, Churchill T, Gautam S, Chinitz JS, Barbhaiya CR, Kumar S, John RM, Tedrow UB, Koplan BA, Stevenson WG, Michaud GF
Pacing Clin Electrophysiol 2017 Feb;40(2):183-190. doi: 10.1111/pace.13013. PMID: 28054374
Tao S, Otomo K, Ono Y, Osaka Y, Hirao T, Koura K, Manno T, Ueshima D, Shimizu S, Isobe M, Hirao K
J Interv Card Electrophysiol 2017 Mar;48(2):167-175. Epub 2016 Dec 9 doi: 10.1007/s10840-016-0214-6. PMID: 27943112
Somjen D, Sharfman ZT, Katzburg S, Sharon O, Maman E, Salai M, Stern N, Dolkart O
Connect Tissue Res 2017 Mar;58(2):215-220. Epub 2016 Aug 11 doi: 10.1080/03008207.2016.1220942. PMID: 27661794

Recent systematic reviews

Barón-Esquivias G, Marín F, Sanmartín Fernandez M
Expert Rev Cardiovasc Ther 2017 May;15(5):403-413. Epub 2017 Mar 28 doi: 10.1080/14779072.2017.1309293. PMID: 28319424
Bai Y, Deng H, Shantsila A, Lip GY
Stroke 2017 Apr;48(4):970-976. Epub 2017 Feb 17 doi: 10.1161/STROKEAHA.116.016275. PMID: 28213573
Bundhun PK, Soogund MZ, Teeluck AR, Pursun M, Bhurtu A, Huang WQ
BMC Cardiovasc Disord 2017 Jan 6;17(1):15. doi: 10.1186/s12872-016-0449-2. PMID: 28056795Free PMC Article
Kubitza D, Berkowitz SD, Misselwitz F
Clin Appl Thromb Hemost 2016 Jul;22(5):412-22. Epub 2016 Feb 18 doi: 10.1177/1076029616631427. PMID: 26893445Free PMC Article
Vamos M, Cappato R, Marchlinski FE, Natale A, Hohnloser SH
Europace 2016 Dec;18(12):1787-1794. Epub 2016 Jan 20 doi: 10.1093/europace/euv408. PMID: 26797248Free PMC Article

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