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Breast hypertrophy

MedGen UID:
43789
•Concept ID:
C0020565
•
Pathologic Function
Synonyms: Drug-induced gigantomastia (subtype); Gestational gigantomastia (subtype); Gigantomastia; Hypertrophy of breast; Idiopathic gigantomastia (subtype); Juvenile gigantomastia (subtype); Medication-induced gigantomastia (subtype); Pregnancy-induced gigantomastia (subtype); Puberty-induced gigantomastia (subtype)
SNOMED CT: Hypertrophy of breast (372281005)
 
HPO: HP:0010313
Monarch Initiative: MONDO:0001100

Definition

The presence of hypertrophy of the breast. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast hypertrophy

Conditions with this feature

Mammary-digital-nail syndrome
MedGen UID:
462296
•Concept ID:
C3150946
•
Disease or Syndrome
A syndromic limb malformation characterized by congenital onychodystrophy/anonychia, brachydactyly of the fifth finger, digitalization of the thumbs, with absence or hypoplasia of the distal phalanges of the hands and feet in association with juvenile hypertrophy of the breast with gigantomastia in peripubertal females.
See: Condition Record
Mammary-digital-nail syndrome

Professional guidelines

PubMed

Poor adherence to clinical guidelines for women undergoing breast reduction.
Aydin D, Hansen LB, Ikander P, Drejøe JB, Lambaa S, Hölmich LR
Dan Med J 2016 Jan;63(1):A5179. PMID: 26726905
The diagnosis and management of breast problems during pregnancy and lactation.
Scott-Conner CE, Schorr SJ
Am J Surg 1995 Oct;170(4):401-5. doi: 10.1016/s0002-9610(99)80313-4. PMID: 7573738
Increased serum prolactin but normal TSH during prolonged domperidone treatment in children.
Deprettere AR, Van Acker KJ, Du Caju MV
Eur J Pediatr 1987 Mar;146(2):189-91. doi: 10.1007/BF02343232. PMID: 3569359

Recent clinical studies

Etiology

Breast Hypertrophy: A Real Pain in the Back.
Lessard L, Papanastasiou C, Fortin M, Ouellet JA
Plast Reconstr Surg 2023 Mar 1;151(3):498-508. Epub 2022 Nov 21 doi: 10.1097/PRS.0000000000009906. PMID: 36730482
Cost-utility analysis of breast reduction surgery for women with symptomatic breast hypertrophy.
Crittenden TA, Ratcliffe J, Watson DI, Mpundu-Kaambwa C, Dean NR
Med J Aust 2022 Feb 21;216(3):147-152. Epub 2021 Nov 16 doi: 10.5694/mja2.51343. PMID: 34784653
Validation of the breast evaluation questionnaire for breast hypertrophy and breast reduction.
Lewin R, Elander A, Lundberg J, Hansson E, Thorarinsson A, Claudelin M, Bladh H, Lidén M
J Plast Surg Hand Surg 2018 Oct;52(5):274-281. Epub 2018 Jun 13 doi: 10.1080/2000656X.2018.1476362. PMID: 29897268
Breast Hypertrophy, Reduction Mammaplasty, and Body Image.
Fonseca CC, Veiga DF, Garcia EDS, Cabral IV, de Carvalho MM, de Brito MJA, Ferreira LM
Aesthet Surg J 2018 Aug 16;38(9):972-979. doi: 10.1093/asj/sjx271. PMID: 29425275
Breast reduction in adolescents: indication, timing, and a review of the literature.
Xue AS, Wolfswinkel EM, Weathers WM, Chike-Obi C, Heller L
J Pediatr Adolesc Gynecol 2013 Aug;26(4):228-33. doi: 10.1016/j.jpag.2013.03.005. PMID: 23889919

Diagnosis

Juvenile breast hypertrophy.
Bianchi de Aguiar B, Santos Silva R, Costa C, Castro-Correia C, Fontoura M
Endokrynol Pol 2020;71(2):202-203. Epub 2020 Jan 7 doi: 10.5603/EP.a2019.0063. PMID: 31909454
Female Sexual Function and Sexual Well-being Before and After Breast Reduction: A Pilot Cross-sectional Study and Review of Literature.
Janik PE, Charytonowicz D, Miszczyk J, Charytonowicz M
Ann Plast Surg 2019 Jun;82(6):609-613. doi: 10.1097/SAP.0000000000001742. PMID: 30557191
Breast Reduction: The Superolateral Dermoglandular Pedicle Revisited.
Uebel CO, Piccinini PS, Ramos RFM, Meneguzzi K
Aesthetic Plast Surg 2019 Feb;43(1):36-45. Epub 2018 Sep 26 doi: 10.1007/s00266-018-1225-8. PMID: 30259167
The diagnosis and management of breast problems during pregnancy and lactation.
Scott-Conner CE, Schorr SJ
Am J Surg 1995 Oct;170(4):401-5. doi: 10.1016/s0002-9610(99)80313-4. PMID: 7573738
Virginal breast hypertrophy.
Griffith JR
J Adolesc Health Care 1989 Sep;10(5):423-32. doi: 10.1016/0197-0070(89)90224-6. PMID: 2681107

Therapy

A review of pediatric macromastia etiology and indications for reduction mammaplasty.
Kikuchi DS, Mustin DE, Ghanouni A, Walsh MD
J Plast Reconstr Aesthet Surg 2023 Feb;77:209-217. Epub 2022 Dec 19 doi: 10.1016/j.bjps.2022.12.003. PMID: 36587475
Swedish Normative Scores for the BREAST-Q Reduction/Mastopexy Module.
Tunå Butt S, Widmark-Jensen E, Meyer S, Hansson E
Aesthetic Plast Surg 2023 Feb;47(1):73-80. Epub 2022 Aug 3 doi: 10.1007/s00266-022-03025-z. PMID: 35920862Free PMC Article
The Impact of Combined Oral Contraceptives on Adolescents with Macromastia.
Nuzzi LC, Pramanick T, Massey GG, Walsh LR, McNamara CT, Firriolo JM, DiVasta AD, Labow BI
Plast Reconstr Surg 2022 Oct 1;150(4):731-738. Epub 2022 Jul 22 doi: 10.1097/PRS.0000000000009513. PMID: 35862103
Juvenile breast hypertrophy.
Bianchi de Aguiar B, Santos Silva R, Costa C, Castro-Correia C, Fontoura M
Endokrynol Pol 2020;71(2):202-203. Epub 2020 Jan 7 doi: 10.5603/EP.a2019.0063. PMID: 31909454
Breast reduction in adolescents: indication, timing, and a review of the literature.
Xue AS, Wolfswinkel EM, Weathers WM, Chike-Obi C, Heller L
J Pediatr Adolesc Gynecol 2013 Aug;26(4):228-33. doi: 10.1016/j.jpag.2013.03.005. PMID: 23889919

Prognosis

Breast Hypertrophy: A Real Pain in the Back.
Lessard L, Papanastasiou C, Fortin M, Ouellet JA
Plast Reconstr Surg 2023 Mar 1;151(3):498-508. Epub 2022 Nov 21 doi: 10.1097/PRS.0000000000009906. PMID: 36730482
The no-vertical scar technique for oncoplastic breast reconstruction.
Venardi A, Newsom KD, DeBrock W, Pittelkow E, Lester M, Fisher CS, Ludwig KK, Hadad I, Hassanein AH
J Plast Reconstr Aesthet Surg 2023 Jan;76:136-141. Epub 2022 Oct 17 doi: 10.1016/j.bjps.2022.10.013. PMID: 36516504
Outcomes of Breast Reduction Surgery Using the BREAST-Q: A Prospective Study and Comparison with Normative Data.
Crittenden TA, Watson DI, Ratcliffe J, Griffin PA, Dean NR
Plast Reconstr Surg 2019 Nov;144(5):1034-1044. doi: 10.1097/PRS.0000000000006114. PMID: 31688747
Sexual Function and Depression Outcomes Among Breast Hypertrophy Patients Undergoing Reduction Mammaplasty: A Randomized Controlled Trial.
Beraldo FN, Veiga DF, Veiga-Filho J, Garcia ES, Vilas-Bôas GS, Juliano Y, Sabino-Neto M, Ferreira LM
Ann Plast Surg 2016 Apr;76(4):379-82. doi: 10.1097/SAP.0000000000000380. PMID: 25536204
The diagnosis and management of breast problems during pregnancy and lactation.
Scott-Conner CE, Schorr SJ
Am J Surg 1995 Oct;170(4):401-5. doi: 10.1016/s0002-9610(99)80313-4. PMID: 7573738

Clinical prediction guides

Breast Hypertrophy: A Real Pain in the Back.
Lessard L, Papanastasiou C, Fortin M, Ouellet JA
Plast Reconstr Surg 2023 Mar 1;151(3):498-508. Epub 2022 Nov 21 doi: 10.1097/PRS.0000000000009906. PMID: 36730482
Swedish Normative Scores for the BREAST-Q Reduction/Mastopexy Module.
Tunå Butt S, Widmark-Jensen E, Meyer S, Hansson E
Aesthetic Plast Surg 2023 Feb;47(1):73-80. Epub 2022 Aug 3 doi: 10.1007/s00266-022-03025-z. PMID: 35920862Free PMC Article
Cost-utility analysis of breast reduction surgery for women with symptomatic breast hypertrophy.
Crittenden TA, Ratcliffe J, Watson DI, Mpundu-Kaambwa C, Dean NR
Med J Aust 2022 Feb 21;216(3):147-152. Epub 2021 Nov 16 doi: 10.5694/mja2.51343. PMID: 34784653
Breast Hypertrophy, Reduction Mammaplasty, and Body Image.
Fonseca CC, Veiga DF, Garcia EDS, Cabral IV, de Carvalho MM, de Brito MJA, Ferreira LM
Aesthet Surg J 2018 Aug 16;38(9):972-979. doi: 10.1093/asj/sjx271. PMID: 29425275
Juvenile gigantomastia.
Samuelov R, Siplovich L
J Pediatr Surg 1988 Nov;23(11):1014-5. doi: 10.1016/s0022-3468(88)80010-1. PMID: 3244074

Recent systematic reviews

A systematic review and meta-analysis of risks and benefits with breast reduction in the public healthcare system: priorities for further research.
Widmark-Jensen E, Bernhardsson S, Eriksson M, Hallberg H, Jepsen C, Jivegård L, Liljegren A, Petzold M, Svensson M, Wärnberg F, Hansson E
BMC Surg 2021 Sep 11;21(1):343. doi: 10.1186/s12893-021-01336-7. PMID: 34511096Free PMC Article
Effect of Reduction Mammoplasty on Pulmonary Function Tests: A Systematic Review.
Guliyeva G, Cheung JY, Avila FR, Huayllani MT, Boczar D, Broer PN, Forte AJ
Ann Plast Surg 2021 Dec 1;87(6):694-698. doi: 10.1097/SAP.0000000000002834. PMID: 33883434
Postoperative Health-related Quality of Life in Reduction Mammaplasty: A Systematic Review and Meta-Analysis.
Lin Y, Yang Y, Zhang X, Li W, Li H, Mu D
Ann Plast Surg 2021 Jul 1;87(1):107-112. doi: 10.1097/SAP.0000000000002609. PMID: 33346564
Breast reconstruction after nipple-sparing mastectomy in the large and/or ptotic breast: A systematic review of indications, techniques, and outcomes.
Tondu T, Hubens G, Tjalma WA, Thiessen FE, Vrints I, Van Thielen J, Verhoeven V
J Plast Reconstr Aesthet Surg 2020 Mar;73(3):469-485. Epub 2019 Dec 18 doi: 10.1016/j.bjps.2019.11.047. PMID: 31987776
Outcomes and Outcome Measures in Breast Reduction Mammaplasty: A Systematic Review.
Waltho D, Gallo L, Gallo M, Murphy J, Copeland A, Mowakket S, Moltaji S, Baxter C, Karpinski M, Thoma A
Aesthet Surg J 2020 Mar 23;40(4):383-391. doi: 10.1093/asj/sjz308. PMID: 31679031

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