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Opiate agonist

MedGen UID:
66892
Concept ID:
C0242402
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
Synonyms: Opioids
SNOMED CT: Opiate agonist (404642006); Opioid (404642006); Opioid product (360204007); Opiate agonist product (360204007); Opiate product (360204007)
 

Definition

A class of synthetic chemicals/drugs similar to opiates (opium derivatives) with analgesic properties. Due to binding to opiate receptors, opioids mimic opiate activity on neurons, various cells (i.e. lymphocytes), pain suppression and other neurobehavioral activity. (NCI) [from NCI]

Recent clinical studies

Etiology

Page K, Tsui J, Maher L, Choopanya K, Vanichseni S, Mock PA, Celum C, Martin M
J Acquir Immune Defic Syndr 2015 Jun 1;69 Suppl 2:S169-75. doi: 10.1097/QAI.0000000000000641. PMID: 25978484Free PMC Article
Hartzler B, Cotton AJ, Calsyn DA, Guerra R, Gignoux E
Int J Drug Policy 2010 Jan;21(1):82-5. Epub 2009 Mar 10 doi: 10.1016/j.drugpo.2009.01.005. PMID: 19278847
Lloyd JJ, Strathdee SA, Pu M, Havens JR, Cornelius LJ, Huettner S, Latkin CA
Am J Addict 2008 Sep-Oct;17(5):414-21. doi: 10.1080/10550490802268165. PMID: 18770085
Hesse M
Br J Clin Psychol 2006 Sep;45(Pt 3):417-25. PMID: 17147106
Lloyd JJ, Ricketts EP, Strathdee SA, Cornelius LJ, Bishai D, Huettner S, Havens JR, Latkin C
Am J Drug Alcohol Abuse 2005;31(4):555-70. PMID: 16320434Free PMC Article

Diagnosis

Furnari M, Epstein DH, Phillips KA, Jobes ML, Kowalczyk WJ, Vahabzadeh M, Lin JL, Preston KL
Psychopharmacology (Berl) 2015 Oct;232(19):3529-37. Epub 2015 Jul 9 doi: 10.1007/s00213-015-3998-7. PMID: 26153066
Havens JR, Latkin CA, Pu M, Cornelius LJ, Bishai D, Huettner S, Rapp C, Ricketts EP, Lloyd JJ, Strathdee SA
J Subst Abuse Treat 2009 Apr;36(3):306-12. Epub 2008 Oct 5 doi: 10.1016/j.jsat.2008.07.002. PMID: 18835681
Hesse M
Br J Clin Psychol 2006 Sep;45(Pt 3):417-25. PMID: 17147106
Lloyd JJ, Ricketts EP, Strathdee SA, Cornelius LJ, Bishai D, Huettner S, Havens JR, Latkin C
Am J Drug Alcohol Abuse 2005;31(4):555-70. PMID: 16320434Free PMC Article
Ambrosi B, Bochicchio D, Ferrario R, Colombo P, Faglia G
J Endocrinol Invest 1989 Jan;12(1):31-5. doi: 10.1007/BF03349913. PMID: 2545766

Therapy

Page K, Tsui J, Maher L, Choopanya K, Vanichseni S, Mock PA, Celum C, Martin M
J Acquir Immune Defic Syndr 2015 Jun 1;69 Suppl 2:S169-75. doi: 10.1097/QAI.0000000000000641. PMID: 25978484Free PMC Article
Havens JR, Latkin CA, Pu M, Cornelius LJ, Bishai D, Huettner S, Rapp C, Ricketts EP, Lloyd JJ, Strathdee SA
J Subst Abuse Treat 2009 Apr;36(3):306-12. Epub 2008 Oct 5 doi: 10.1016/j.jsat.2008.07.002. PMID: 18835681
Lloyd JJ, Strathdee SA, Pu M, Havens JR, Cornelius LJ, Huettner S, Latkin CA
Am J Addict 2008 Sep-Oct;17(5):414-21. doi: 10.1080/10550490802268165. PMID: 18770085
Hesse M
Br J Clin Psychol 2006 Sep;45(Pt 3):417-25. PMID: 17147106
Lloyd JJ, Ricketts EP, Strathdee SA, Cornelius LJ, Bishai D, Huettner S, Havens JR, Latkin C
Am J Drug Alcohol Abuse 2005;31(4):555-70. PMID: 16320434Free PMC Article

Prognosis

Furnari M, Epstein DH, Phillips KA, Jobes ML, Kowalczyk WJ, Vahabzadeh M, Lin JL, Preston KL
Psychopharmacology (Berl) 2015 Oct;232(19):3529-37. Epub 2015 Jul 9 doi: 10.1007/s00213-015-3998-7. PMID: 26153066
Havens JR, Latkin CA, Pu M, Cornelius LJ, Bishai D, Huettner S, Rapp C, Ricketts EP, Lloyd JJ, Strathdee SA
J Subst Abuse Treat 2009 Apr;36(3):306-12. Epub 2008 Oct 5 doi: 10.1016/j.jsat.2008.07.002. PMID: 18835681
Hesse M
Br J Clin Psychol 2006 Sep;45(Pt 3):417-25. PMID: 17147106
Lloyd JJ, Ricketts EP, Strathdee SA, Cornelius LJ, Bishai D, Huettner S, Havens JR, Latkin C
Am J Drug Alcohol Abuse 2005;31(4):555-70. PMID: 16320434Free PMC Article
Oreskovich MR, Saxon AJ, Ellis ML, Malte CA, Reoux JP, Knox PC
Drug Alcohol Depend 2005 Jan 7;77(1):71-9. doi: 10.1016/j.drugalcdep.2004.07.008. PMID: 15607843

Clinical prediction guides

Havens JR, Latkin CA, Pu M, Cornelius LJ, Bishai D, Huettner S, Rapp C, Ricketts EP, Lloyd JJ, Strathdee SA
J Subst Abuse Treat 2009 Apr;36(3):306-12. Epub 2008 Oct 5 doi: 10.1016/j.jsat.2008.07.002. PMID: 18835681
Hesse M
Br J Clin Psychol 2006 Sep;45(Pt 3):417-25. PMID: 17147106
Lloyd JJ, Ricketts EP, Strathdee SA, Cornelius LJ, Bishai D, Huettner S, Havens JR, Latkin C
Am J Drug Alcohol Abuse 2005;31(4):555-70. PMID: 16320434Free PMC Article
Oreskovich MR, Saxon AJ, Ellis ML, Malte CA, Reoux JP, Knox PC
Drug Alcohol Depend 2005 Jan 7;77(1):71-9. doi: 10.1016/j.drugalcdep.2004.07.008. PMID: 15607843
Ambrosi B, Bochicchio D, Ferrario R, Colombo P, Faglia G
J Endocrinol Invest 1989 Jan;12(1):31-5. doi: 10.1007/BF03349913. PMID: 2545766

Recent systematic reviews

Hiyama T, Yoshihara M, Matsuo K, Kusunoki H, Kamada T, Ito M, Tanaka S, Chayama K, Haruma K
J Gastroenterol Hepatol 2007 Oct;22(10):1566-70. doi: 10.1111/j.1440-1746.2006.04723.x. PMID: 17845684
JAMA 1998 Dec 9;280(22):1936-43. PMID: 9851480

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