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Pertussis

MedGen UID:
12159
Concept ID:
C0043167
Disease or Syndrome
Synonyms: Bordetella pertussis Infection, Respiratory; Cough, Whooping; Pertusses; Whooping Cough
SNOMED CT: Pertussis (27836007); Infection due to Bordetella pertussis (27836007); Whooping cough (27836007); WC - Whooping cough (27836007)
 
Orphanet: ORPHA1489

Definition

Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. The name comes from the noise you make when you take a breath after you cough. You may have choking spells or may cough so hard that you vomit. . Anyone can get whooping cough, but it is more common in infants and children. It's especially dangerous in infants. The coughing spells can be so bad that it is hard for infants to eat, drink or breathe. . Before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the U.S. There are fewer cases today because there are both pertussis-only vaccines and combination vaccines for tetanus, diphtheria and pertussis. If you have whooping cough, treatment with antibiotics may help if given early. Centers for Disease Control and Prevention.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPertussis
Follow this link to review classifications for Pertussis in Orphanet.

Recent clinical studies

Etiology

Huang WT, Lin HC, Yang CH
Hum Vaccin Immunother 2017 Apr 3;13(4):757-761. Epub 2016 Nov 18 doi: 10.1080/21645515.2016.1249552. PMID: 27858500Free PMC Article
Fedele G, Carollo M, Palazzo R, Stefanelli P, Pandolfi E, Gesualdo F, Tozzi AE, Carsetti R, Villani A, Nicolai A, Midulla F, Ausiello CM; Pertussis Study Group.
Infection 2017 Apr;45(2):171-178. Epub 2016 Sep 10 doi: 10.1007/s15010-016-0943-6. PMID: 27614887
Godoy P, García-Cenoz M, Toledo D, Carmona G, Caylà JA, Alsedà M, Àlvarez J, Barrabeig I, Camps N, Plans P, Company M, Castilla J, Sala-Farré MR, Muñoz-Almagro C, Rius C, Domínguez À; Transmission of Pertussis in Households Working Group.
Euro Surveill 2016 Nov 10;21(45) doi: 10.2807/1560-7917.ES.2016.21.45.30393. PMID: 27918260Free PMC Article
Nakamura K, Kobayashi M, Yamamoto N, Tokuda K, Miura S, Abe Y, Kashiwazaki J, Aoyagi T, Kaku M, Kanemitsu K
J Hosp Infect 2016 Dec;94(4):341-345. Epub 2016 Oct 17 doi: 10.1016/j.jhin.2016.09.011. PMID: 27760708
Williams MM, Sen K, Weigand MR, Skoff TH, Cunningham VA, Halse TA, Tondella ML; CDC Pertussis Working Group.
Emerg Infect Dis 2016 Feb;22(2):319-22. doi: 10.3201/eid2202.151332. PMID: 26812174Free PMC Article

Diagnosis

Riise ØR, Laake I, Vestrheim D, Flem E, Moster D, Riise Bergsaker MA, Storsæter J
Pediatr Infect Dis J 2017 May;36(5):e151-e156. doi: 10.1097/INF.0000000000001545. PMID: 28403056
Fedele G, Carollo M, Palazzo R, Stefanelli P, Pandolfi E, Gesualdo F, Tozzi AE, Carsetti R, Villani A, Nicolai A, Midulla F, Ausiello CM; Pertussis Study Group.
Infection 2017 Apr;45(2):171-178. Epub 2016 Sep 10 doi: 10.1007/s15010-016-0943-6. PMID: 27614887
Godoy P, García-Cenoz M, Toledo D, Carmona G, Caylà JA, Alsedà M, Àlvarez J, Barrabeig I, Camps N, Plans P, Company M, Castilla J, Sala-Farré MR, Muñoz-Almagro C, Rius C, Domínguez À; Transmission of Pertussis in Households Working Group.
Euro Surveill 2016 Nov 10;21(45) doi: 10.2807/1560-7917.ES.2016.21.45.30393. PMID: 27918260Free PMC Article
Otsuka N, Gotoh K, Nishimura N, Ozaki T, Nakamura Y, Haga K, Yamazaki M, Gondaira F, Okada K, Miyaji Y, Toyoizumi-Ajisaka H, Shibayama K, Arakawa Y, Kamachi K
Microbiol Immunol 2016 May;60(5):326-33. doi: 10.1111/1348-0421.12378. PMID: 26996337
Monaco F, Barone M, Manfredi VG, Marando R, Nunnari F, David A, Monaco M, Cascio A
Clin Respir J 2016 Nov;10(6):772-776. Epub 2015 Apr 15 doi: 10.1111/crj.12285. PMID: 25764484

Therapy

Huang WT, Lin HC, Yang CH
Hum Vaccin Immunother 2017 Apr 3;13(4):757-761. Epub 2016 Nov 18 doi: 10.1080/21645515.2016.1249552. PMID: 27858500Free PMC Article
Locht C
Clin Microbiol Infect 2016 Dec 1;22 Suppl 5:S96-S102. Epub 2016 Oct 27 doi: 10.1016/j.cmi.2016.05.029. PMID: 28341014
Godoy P, García-Cenoz M, Toledo D, Carmona G, Caylà JA, Alsedà M, Àlvarez J, Barrabeig I, Camps N, Plans P, Company M, Castilla J, Sala-Farré MR, Muñoz-Almagro C, Rius C, Domínguez À; Transmission of Pertussis in Households Working Group.
Euro Surveill 2016 Nov 10;21(45) doi: 10.2807/1560-7917.ES.2016.21.45.30393. PMID: 27918260Free PMC Article
Gröndahl-Yli-Hannuksela K, Vahlberg T, Ilonen J, Mertsola J, He Q
Immunogenetics 2016 Oct;68(9):733-41. Epub 2016 Jun 10 doi: 10.1007/s00251-016-0923-0. PMID: 27282930
Esposito S, Principi N; European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Vaccine Study Group (EVASG).
Clin Microbiol Infect 2016 Dec 1;22 Suppl 5:S89-S95. Epub 2016 Apr 26 doi: 10.1016/j.cmi.2016.01.003. PMID: 27130670

Prognosis

Godoy P, García-Cenoz M, Toledo D, Carmona G, Caylà JA, Alsedà M, Àlvarez J, Barrabeig I, Camps N, Plans P, Company M, Castilla J, Sala-Farré MR, Muñoz-Almagro C, Rius C, Domínguez À; Transmission of Pertussis in Households Working Group.
Euro Surveill 2016 Nov 10;21(45) doi: 10.2807/1560-7917.ES.2016.21.45.30393. PMID: 27918260Free PMC Article
Choi YH, Campbell H, Amirthalingam G, van Hoek AJ, Miller E
BMC Med 2016 Sep 1;14(1):121. doi: 10.1186/s12916-016-0665-8. PMID: 27580649Free PMC Article
Brotons P, de Paz HD, Toledo D, Villanova M, Plans P, Jordan I, Dominguez A, Jane M, Godoy P, Muñoz-Almagro C; Working Group “Transmission of Pertussis in Households”.
J Infect 2016 Apr;72(4):460-7. Epub 2016 Feb 3 doi: 10.1016/j.jinf.2016.01.013. PMID: 26850358
Nguyen AW, Wagner EK, Laber JR, Goodfield LL, Smallridge WE, Harvill ET, Papin JF, Wolf RF, Padlan EA, Bristol A, Kaleko M, Maynard JA
Sci Transl Med 2015 Dec 2;7(316):316ra195. doi: 10.1126/scitranslmed.aad0966. PMID: 26631634Free PMC Article
Clarke M, Thomas N, Giles L, Marshall H
Vaccine 2015 Dec 16;33(51):7337-43. Epub 2015 Oct 26 doi: 10.1016/j.vaccine.2015.10.068. PMID: 26514422

Clinical prediction guides

Riise ØR, Laake I, Vestrheim D, Flem E, Moster D, Riise Bergsaker MA, Storsæter J
Pediatr Infect Dis J 2017 May;36(5):e151-e156. doi: 10.1097/INF.0000000000001545. PMID: 28403056
Rocha EL, Leite D, Camargo CH, Martins LM, Silva RSN, Martins VP, Campos TA
Epidemiol Infect 2017 May;145(7):1392-1397. Epub 2017 Feb 21 doi: 10.1017/S0950268816003332. PMID: 28219454
Locht C
Clin Microbiol Infect 2016 Dec 1;22 Suppl 5:S96-S102. Epub 2016 Oct 27 doi: 10.1016/j.cmi.2016.05.029. PMID: 28341014
Choi YH, Campbell H, Amirthalingam G, van Hoek AJ, Miller E
BMC Med 2016 Sep 1;14(1):121. doi: 10.1186/s12916-016-0665-8. PMID: 27580649Free PMC Article
Safarchi A, Octavia S, Wu SZ, Kaur S, Sintchenko V, Gilbert GL, Wood N, McIntyre P, Marshall H, Keil AD, Lan R
J Infect 2016 Apr;72(4):468-77. Epub 2016 Jan 27 doi: 10.1016/j.jinf.2016.01.005. PMID: 26826518

Recent systematic reviews

Fulton TR, Phadke VK, Orenstein WA, Hinman AR, Johnson WD, Omer SB
Clin Infect Dis 2016 May 1;62(9):1100-1110. Epub 2016 Feb 7 doi: 10.1093/cid/ciw051. PMID: 26908803Free PMC Article
Tan T, Dalby T, Forsyth K, Halperin SA, Heininger U, Hozbor D, Plotkin S, Ulloa-Gutierrez R, Wirsing von König CH
Pediatr Infect Dis J 2015 Sep;34(9):e222-32. doi: 10.1097/INF.0000000000000795. PMID: 26376316
Muloiwa R, Kagina BM, Engel ME, Hussey GD
Syst Rev 2015 May 1;4:62. doi: 10.1186/s13643-015-0053-z. PMID: 25930111Free PMC Article
McGirr A, Fisman DN
Pediatrics 2015 Feb;135(2):331-43. Epub 2015 Jan 5 doi: 10.1542/peds.2014-1729. PMID: 25560446
Tarr GA, Eickhoff JC, Koepke R, Hopfensperger DJ, Davis JP, Conway JH
Am J Epidemiol 2013 Jul 15;178(2):309-18. Epub 2013 Jun 4 doi: 10.1093/aje/kws465. PMID: 23735308Free PMC Article

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