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Intravenous immunoglobulin

MedGen UID:
38840
Concept ID:
C0085297
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
Synonyms: Antibodies, Intravenous; Immune Globulin, Intravenous; Immunoglobulins, Intravenous; Immunoglobulins, IV; Intravenous Antibodies; Intravenous IG; Intravenous Immune Globulin; Intravenous Immunoglobulins; IV Immunoglobulins; IVIG
SNOMED CT: Intravenous immunoglobulin (350344000)
 

Definition

Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntravenous immunoglobulin

Recent clinical studies

Etiology

Elalfy M, Reda M, Elghamry I, Elalfy O, Meabed M, El-Ekiaby N, El-Hawy MA, Goubran H, El-Ekiaby M
Transfusion 2017 Dec;57(12):3019-3025. Epub 2017 Sep 6 doi: 10.1111/trf.14301. PMID: 28880361
de Greef BT, Geerts M, Hoeijmakers JG, Faber CG, Merkies IS
Trials 2016 Jul 20;17(1):330. doi: 10.1186/s13063-016-1450-x. PMID: 27439408Free PMC Article
Bello-Espinosa LE, Rajapakse T, Rho JM, Buchhalter J
Pediatr Neurol 2015 May;52(5):509-16. Epub 2015 Feb 13 doi: 10.1016/j.pediatrneurol.2014.11.011. PMID: 25882078
Yang X, Liu G, Huang Y, Chen S, Du J, Jin H
Cardiol Young 2015 Aug;25(6):1182-90. Epub 2015 Jan 19 doi: 10.1017/S1047951114002601. PMID: 25597708
Xie Z, Chan EC, Long LM, Nelson C, Druey KM
Am J Med 2015 Jan;128(1):91-5. Epub 2014 Sep 3 doi: 10.1016/j.amjmed.2014.08.015. PMID: 25193271Free PMC Article

Diagnosis

Elalfy M, Reda M, Elghamry I, Elalfy O, Meabed M, El-Ekiaby N, El-Hawy MA, Goubran H, El-Ekiaby M
Transfusion 2017 Dec;57(12):3019-3025. Epub 2017 Sep 6 doi: 10.1111/trf.14301. PMID: 28880361
Vo ML, Chin RL, Miranda C, Latov N
Muscle Nerve 2017 Oct;56(4):732-736. Epub 2017 Mar 24 doi: 10.1002/mus.25553. PMID: 28085193
Song R, Yao W, Li X
J Pediatr 2017 May;184:120-124. Epub 2016 Dec 30 doi: 10.1016/j.jpeds.2016.12.018. PMID: 28043682
Shenoy N, Tesfaye M, Brown J, Simmons N, Weiss D, Meholli M, Mabie P
Pract Neurol 2015 Aug;15(4):289-92. Epub 2015 May 2 doi: 10.1136/practneurol-2015-001112. PMID: 25935926
Dodel R, Rominger A, Bartenstein P, Barkhof F, Blennow K, Förster S, Winter Y, Bach JP, Popp J, Alferink J, Wiltfang J, Buerger K, Otto M, Antuono P, Jacoby M, Richter R, Stevens J, Melamed I, Goldstein J, Haag S, Wietek S, Farlow M, Jessen F
Lancet Neurol 2013 Mar;12(3):233-43. Epub 2013 Jan 31 doi: 10.1016/S1474-4422(13)70014-0. PMID: 23375965Free PMC Article

Therapy

Elalfy M, Reda M, Elghamry I, Elalfy O, Meabed M, El-Ekiaby N, El-Hawy MA, Goubran H, El-Ekiaby M
Transfusion 2017 Dec;57(12):3019-3025. Epub 2017 Sep 6 doi: 10.1111/trf.14301. PMID: 28880361
de Greef BT, Geerts M, Hoeijmakers JG, Faber CG, Merkies IS
Trials 2016 Jul 20;17(1):330. doi: 10.1186/s13063-016-1450-x. PMID: 27439408Free PMC Article
Bello-Espinosa LE, Rajapakse T, Rho JM, Buchhalter J
Pediatr Neurol 2015 May;52(5):509-16. Epub 2015 Feb 13 doi: 10.1016/j.pediatrneurol.2014.11.011. PMID: 25882078
Yang X, Liu G, Huang Y, Chen S, Du J, Jin H
Cardiol Young 2015 Aug;25(6):1182-90. Epub 2015 Jan 19 doi: 10.1017/S1047951114002601. PMID: 25597708
Xie Z, Chan EC, Long LM, Nelson C, Druey KM
Am J Med 2015 Jan;128(1):91-5. Epub 2014 Sep 3 doi: 10.1016/j.amjmed.2014.08.015. PMID: 25193271Free PMC Article

Prognosis

Song R, Yao W, Li X
J Pediatr 2017 May;184:120-124. Epub 2016 Dec 30 doi: 10.1016/j.jpeds.2016.12.018. PMID: 28043682
Shenoy N, Tesfaye M, Brown J, Simmons N, Weiss D, Meholli M, Mabie P
Pract Neurol 2015 Aug;15(4):289-92. Epub 2015 May 2 doi: 10.1136/practneurol-2015-001112. PMID: 25935926
Clark SL, Rabinstein AA
Neurol Res 2015 Jul;37(7):593-8. Epub 2015 Mar 9 doi: 10.1179/1743132815Y.0000000017. PMID: 25751423
Xie Z, Chan EC, Long LM, Nelson C, Druey KM
Am J Med 2015 Jan;128(1):91-5. Epub 2014 Sep 3 doi: 10.1016/j.amjmed.2014.08.015. PMID: 25193271Free PMC Article
Marković-Sovtić G, Janković B, Rakonjac Z, Martić J, Pejić K
Vojnosanit Pregl 2013 Nov;70(11):1029-33. PMID: 24397198

Clinical prediction guides

Negm OH, MacKenzie B, Hamed MR, Ahmad OAJ, Shone CC, Humphreys DP, Ravi Acharya K, Loscher CE, Marszalowska I, Lynch M, Wilcox MH, Monaghan TM
Clin Exp Immunol 2017 Jun;188(3):437-443. Epub 2017 Mar 16 doi: 10.1111/cei.12946. PMID: 28213939Free PMC Article
Vo ML, Chin RL, Miranda C, Latov N
Muscle Nerve 2017 Oct;56(4):732-736. Epub 2017 Mar 24 doi: 10.1002/mus.25553. PMID: 28085193
Song R, Yao W, Li X
J Pediatr 2017 May;184:120-124. Epub 2016 Dec 30 doi: 10.1016/j.jpeds.2016.12.018. PMID: 28043682
Pritchard J, Hughes RA, Hadden RD, Brassington R
Cochrane Database Syst Rev 2016 Nov 15;11:CD008630. doi: 10.1002/14651858.CD008630.pub4. PMID: 27846348
Ishikura H, Nakamura Y, Kawano Y, Tanaka J, Mizunuma M, Ohta D, Nishida T, Murai A
J Crit Care 2015 Jun;30(3):579-83. Epub 2015 Feb 28 doi: 10.1016/j.jcrc.2015.02.012. PMID: 25776897

Recent systematic reviews

Pritchard J, Hughes RA, Hadden RD, Brassington R
Cochrane Database Syst Rev 2016 Nov 15;11:CD008630. doi: 10.1002/14651858.CD008630.pub4. PMID: 27846348
Wang J, McQuilten ZK, Wood EM, Aubron C
J Crit Care 2015 Jun;30(3):652.e9-16. Epub 2015 Feb 7 doi: 10.1016/j.jcrc.2015.01.022. PMID: 25702845
Yang X, Liu G, Huang Y, Chen S, Du J, Jin H
Cardiol Young 2015 Aug;25(6):1182-90. Epub 2015 Jan 19 doi: 10.1017/S1047951114002601. PMID: 25597708
Franco AC, Torrico AC, Moreira FT, Sá FP, D'Elia HV, Bernardo WM
J Pediatr (Rio J) 2012 Sep-Oct;88(5):377-83. Epub 2012 Sep 22 doi: doi:10.2223/JPED.2218. PMID: 23002082
Hughes RA, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2010 Jun 16;(6):CD002063. doi: 10.1002/14651858.CD002063.pub4. PMID: 20556755

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