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Items: 1 to 20 of 53

1.

Infection

The invasion of an organism's body tissues by disease-causing agents and their multiplication, as well as the reaction by the host to these organisms and/or toxins that the organisms produce. [from NCI]

MedGen UID:
811352
Concept ID:
C3714514
Pathologic Function
2.

Oxidative Stress

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products. The damage to biological tissues is caused by superoxide and other free radicals generated by many factors, including exposure to alcohol, medications, trauma, cold, toxins, and radiation or by antimicrobial cellular immunity, metabolic abnormality, or "normal" aging; not synonymous with hypoxia or hyperoxia. Oxidative stress promotes a range of degenerative disorders, including cancer, diabetes, premature aging, Alzheimer's, and many others. [from NCI]

MedGen UID:
66929
Concept ID:
C0242606
Cell or Molecular Dysfunction
3.

Stress

The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities. [from NCI]

MedGen UID:
20971
Concept ID:
C0038435
Finding
4.

Iron agent

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. [from MeSH]

MedGen UID:
137068
Concept ID:
C0302583
Biologically Active Substance; Element, Ion, or Isotope; Pharmacologic Substance
5.

Parasitemia

The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed) [from MeSH]

MedGen UID:
116650
Concept ID:
C0242723
Disease or Syndrome
6.

Ferrous sulfate

A sulfate salt of mineral iron formulated for oral administration and used as a dietary supplement, ferrous sulfate is absorbed in the stomach and small intestine and combines with apoferritin to form ferritin, which is stored in the liver, spleen, red bone marrow, and intestinal mucosa. Important in transport of oxygen by hemoglobin to the tissues, iron is also found in myoglobin, transferrin, and ferritin, and is a component of many enzymes such as catalase, peroxidase, and cytochromes. [from NCI]

MedGen UID:
28994
Concept ID:
C0060282
Inorganic Chemical; Pharmacologic Substance
7.

Antioxidant

A group of organic or inorganic substances capable of preventing the genotoxic and carcinogenic effects of free-radical compounds. Antioxidants bind to and neutralize ('scavenge') free radicals, thereby transforming them into non-toxic compounds and blocking their genotoxic and carcinogenic effects. This class of agents includes the vitamins C and E, the carotenoids, and selenium. Organic antioxidants are found in high concentrations in fruits, seeds and vegetables. (NCI04) [from NCI]

MedGen UID:
1608
Concept ID:
C0003402
Pharmacologic Substance
8.

Ferritin

An iron protein complex, containing up to 23% iron, formed by the union of ferric iron with apoferritin; it is found in the intestinal mucosa, spleen, bone marrow, reticulocytes, and liver, and regulates iron storage and transport from the intestinal lumen to plasma. [from NCI]

MedGen UID:
8817
Concept ID:
C0015879
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
9.

Euglenozoa Infections

Infections with the protozoa of the phylum EUGLENOZOA. [from MeSH]

MedGen UID:
404001
Concept ID:
C2717956
Disease or Syndrome
10.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
11.

Antimicrobial substance

Generically, any agent that destroys microbes. However, usage of the term is increasingly being confined to agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES. [from MeSH]

MedGen UID:
209727
Concept ID:
C1136254
Pharmacologic Substance
12.

Physiological stress

The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions. [from MeSH]

MedGen UID:
105278
Concept ID:
C0449430
Pathologic Function
13.

Sepsis

Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK. [from MeSH]

MedGen UID:
69314
Concept ID:
C0243026
Disease or Syndrome
14.

Systemic inflammatory response syndrome

A generalized state of dysregulated inflammation induced by noninfectious processes. It is characterized by two or more of the following signs and symptoms: fever or hypothermia, increased heart rate, increased respiratory rate, and abnormal white blood cell count.(NICHD) [from NCI]

MedGen UID:
69303
Concept ID:
C0242966
Disease or Syndrome
15.

Trypanosomiasis

Infection with protozoa of the genus TRYPANOSOMA. [from MeSH]

MedGen UID:
52872
Concept ID:
C0041227
Disease or Syndrome
16.

Sepsis

Systemic disease associated with the presence of pathogenic microorganisms or their toxins in the blood. [from MeSH]

MedGen UID:
48626
Concept ID:
C0036690
Disease or Syndrome
17.

Disease caused by parasite

Infections or infestations with PARASITES. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure. [from MeSH]

MedGen UID:
45325
Concept ID:
C0030499
Disease or Syndrome
18.

Protozoan infection

An infection that is caused by protozoans. [from NCI]

MedGen UID:
19532
Concept ID:
C0033740
Disease or Syndrome
19.

Protective agent

A class of agents used in prophylactic or curative therapy to attenuate the negative side effects of toxins or drugs. Protective agents belong to various chemical classes, acting through various pharmacological mechanisms. They may neutralize exogenous poisons, coat mucosa for protection against physical or chemical damage, offer antioxidant protection against free radicals or ionizing radiation, or induce endogenous detoxifying enzymes. (NCI04) [from NCI]

MedGen UID:
19516
Concept ID:
C0033613
Pharmacologic Substance
20.

Pyemia

Septicemia caused by pyogenic microorganisms (e.g., STAPHYLOCOCCUS; BACILLUS), resulting in the formation of secondary foci of SUPPURATION and multiple ABSCESSES. [from MeSH]

MedGen UID:
18779
Concept ID:
C0034189
Pathologic Function
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