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Items: 10

1.

STAT3 Decoy Oligonucleotide

A double-stranded 15-mer oligonucleotide, corresponding closely to the signal transducer and activator of transcription 3 (STAT3) response element within the c-fos promoter, with potential antineoplastic activity. STAT3 decoy oligonucleotide binds specifically to activated STAT3 and blocks binding of STAT3 to DNA sequences on a variety of STAT3-responsive promoters, which results in the inhibition of STAT3-mediated transcription and, potentially, the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a variety of cancers including squamous cell carcinoma of the head and neck, contributing to the loss of cell growth control and neoplastic transformation. [from NCI]

MedGen UID:
397106
Concept ID:
C2699258
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
2.

Malignant Neoplasm

Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body. . Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for where they start. For example, lung cancer starts in the lung, and breast cancer starts in the breast. The spread of cancer from one part of the body to another is called metastasis. Symptoms and treatment depend on the cancer type and how advanced it is. Most treatment plans may include surgery, radiation and/or chemotherapy. Some may involve hormone therapy, biologic therapy, or stem cell transplantation. . NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
14297
Concept ID:
C0006826
Neoplastic Process
3.

Instability

MedGen UID:
731956
Concept ID:
C1444783
Finding
4.

Neoplasm

A malignant tumor at the original site of growth. [from NCI]

MedGen UID:
227011
Concept ID:
C1306459
Neoplastic Process
5.

Injectables

A drug or medicine that can be injected [from CHV]

MedGen UID:
88572
Concept ID:
C0086466
Pharmacologic Substance
6.

Neoplasm by Site

A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc. [from MeSH]

MedGen UID:
10296
Concept ID:
C0027653
Neoplastic Process
7.

Head and Neck Neoplasms

A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx. [from HPO]

MedGen UID:
6728
Concept ID:
C0018671
Neoplastic Process
8.

Cerebral anoxia after obstetrical surgery AND/OR other procedure including delivery

MedGen UID:
542396
Concept ID:
C0269927
Disease or Syndrome
9.

Cardiac failure after obstetrical surgery AND/OR other procedure including delivery

MedGen UID:
542395
Concept ID:
C0269926
Disease or Syndrome
10.

Cardiac arrest after obstetrical surgery AND/OR other procedure including delivery

MedGen UID:
542394
Concept ID:
C0269925
Disease or Syndrome
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