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Carpal tunnel syndrome(CTS1)

MedGen UID:
2856
Concept ID:
C0007286
Disease or Syndrome
Synonyms: AMYOTROPHY, THENAR, OF CARPAL ORIGIN; CTS1
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: HPO, OMIM, Orphanet
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
Autosomal dominant inheritance (HPO, OMIM, Orphanet)
SNOMED CT: Distal median nerve compression (57406009); Distal median nerve entrapment (57406009); Median nerve entrapment (246611002); Carpal tunnel (57406009); Carpal canal (57406009); CTS - Carpal tunnel syndrome (57406009); Median nerve compression (57406009); Carpal tunnel syndrome (57406009); Median nerve entrapment (57406009)
 
Gene (location): TTR (18q12.1)
OMIM®: 115430

Definition

You're working at your desk, trying to ignore the tingling or numbness you've had for some time in your hand and wrist. Suddenly, a sharp, piercing pain shoots through the wrist and up your arm. Just a passing cramp? It could be carpal tunnel syndrome. The carpal tunnel is a narrow passageway of ligament and bones at the base of your hand. It contains nerve and tendons. Sometimes, thickening from irritated tendons or other swelling narrows the tunnel and causes the nerve to be compressed. Symptoms usually start gradually. As they worsen, grasping objects can become difficult. Often, the cause is having a smaller carpal tunnel than other people do. Other causes include performing assembly line work, wrist injury, or swelling due to certain diseases, such as rheumatoid arthritis. Women are three times more likely to have carpal tunnel syndrome than men. Early diagnosis and treatment are important to prevent permanent nerve damage. Your doctor diagnoses carpal tunnel syndrome with a physical exam and special nerve tests. Treatment includes resting your hand, splints, pain and anti-inflammatory medicines, and sometimes surgery. . NIH: National Institute of Neurological Disorders and Stroke.  [from MedlinePlus]

Clinical features

Neuropathy
MedGen UID:
141046
Concept ID:
C0442874
Disease or Syndrome
Peripheral neuropathy is a general term for any disorder of the peripheral nervous system. The main clinical features used to classify peripheral neuropathy are distribution, type (mainly demyelinating versus mainly axonal), duration, and course.
Vitamin B6 deficiency
MedGen UID:
215231
Concept ID:
C0936215
Disease or Syndrome
A nutritional condition produced by a deficiency of VITAMIN B 6 in the diet, characterized by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures. Deficiency can be caused by certain medications, such as isoniazid.
Digital flexor tenosynovitis
MedGen UID:
868575
Concept ID:
C4022974
Anatomical Abnormality
Inflammation of the flexor digitorum tendon, often associated with the Kanavel signs: (i) finger held in slight flexion, (ii) fusiform swelling, (iii) tenderness along the flexor tendon sheath, and (iv) pain with passive extension of the digit.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarpal tunnel syndrome

Recent clinical studies

Etiology

Hu K, Zhang T, Xu W
Brain Behav 2016 Feb 16;6(3):e00439. doi: 10.1002/brb3.439. PMID: 27099801Free PMC Article
Sassi SA, Giddins G
J Hand Surg Eur Vol 2016 Jul;41(6):638-42. Epub 2016 Jan 22 doi: 10.1177/1753193415625404. PMID: 26802792
Han SW, Cheon KY, Kim JY, Baik JS
PLoS One 2015 Jun 19;10(6):e0130779. doi: 10.1371/journal.pone.0130779. PMID: 26091110Free PMC Article
Vanni D, Sirabella FS, Galzio R, Salini V, Magliani V
J Neurosurg 2015 Nov;123(5):1230-7. Epub 2015 May 29 doi: 10.3171/2014.11.JNS14901. PMID: 26024005
Kwon BC, Koh SH, Hwang SY
AJR Am J Roentgenol 2015 Jun;204(6):1248-54. doi: 10.2214/AJR.14.13371. PMID: 26001235

Diagnosis

Gillig JD, White SD, Rachel JN
Orthop Clin North Am 2016 Jul;47(3):599-607. doi: 10.1016/j.ocl.2016.03.005. PMID: 27241382
Lee SH, Gong HS, Kim DH, Shin HS, Kim KM, Kim J, Baek GH
J Hand Surg Eur Vol 2016 Jul;41(6):643-7. Epub 2015 Dec 23 doi: 10.1177/1753193415622732. PMID: 26701973
Kang S, Yang SN, Yoon JS, Kang HJ, Won SJ
J Ultrasound Med 2016 Jan;35(1):37-42. Epub 2015 Nov 20 doi: 10.7863/ultra.15.02064. PMID: 26589645
Fowler JR, Cipolli W, Hanson T
J Bone Joint Surg Am 2015 Dec 2;97(23):1958-61. doi: 10.2106/JBJS.O.00476. PMID: 26631997
Han SW, Cheon KY, Kim JY, Baik JS
PLoS One 2015 Jun 19;10(6):e0130779. doi: 10.1371/journal.pone.0130779. PMID: 26091110Free PMC Article

Therapy

Hu K, Zhang T, Xu W
Brain Behav 2016 Feb 16;6(3):e00439. doi: 10.1002/brb3.439. PMID: 27099801Free PMC Article
Curran MW, Olson J, Morhart M, Sample D, Chan KM
Trials 2016 Apr 14;17:200. doi: 10.1186/s13063-016-1324-2. PMID: 27079660Free PMC Article
Gunnoo N, Ebelin M, Arrault M, Vignes S
Breast Cancer Res Treat 2015 Aug;152(3):683-6. Epub 2015 Jul 19 doi: 10.1007/s10549-015-3500-6. PMID: 26187406
Vanni D, Sirabella FS, Galzio R, Salini V, Magliani V
J Neurosurg 2015 Nov;123(5):1230-7. Epub 2015 May 29 doi: 10.3171/2014.11.JNS14901. PMID: 26024005
Atroshi I, Zhou C, Jöud A, Petersson IF, Englund M
PLoS One 2015 Mar 24;10(3):e0119795. doi: 10.1371/journal.pone.0119795. PMID: 25803841Free PMC Article

Prognosis

Gruber L, Gruber H, Djurdjevic T, Schullian P, Loizides A
J Med Ultrason (2001) 2016 Jul;43(3):413-20. Epub 2016 Mar 1 doi: 10.1007/s10396-016-0707-z. PMID: 26932545
Lee SH, Gong HS, Kim DH, Shin HS, Kim KM, Kim J, Baek GH
J Hand Surg Eur Vol 2016 Jul;41(6):643-7. Epub 2015 Dec 23 doi: 10.1177/1753193415622732. PMID: 26701973
Aung KK, Wu WK, Tokumi A, Kuo P, Day CS
J Bone Joint Surg Am 2015 Jul 1;97(13):1112-8. doi: 10.2106/JBJS.N.00741. PMID: 26135078
Kwon BC, Koh SH, Hwang SY
AJR Am J Roentgenol 2015 Jun;204(6):1248-54. doi: 10.2214/AJR.14.13371. PMID: 26001235
Park JH, Kim SN, Han SM, Cheon KY, Han SW, Kim JY, Baik JS, Park JH
J Ultrasound Med 2013 Oct;32(10):1753-7. doi: 10.7863/ultra.32.10.1753. PMID: 24065256

Clinical prediction guides

Hu K, Zhang T, Xu W
Brain Behav 2016 Feb 16;6(3):e00439. doi: 10.1002/brb3.439. PMID: 27099801Free PMC Article
Carvajal A, Martín Arias LH, Sáinz M, Escudero A, Fierro I, Sauzet O, Cornelius VR, Molokhia M
PLoS One 2016 Jan 14;11(1):e0146772. doi: 10.1371/journal.pone.0146772. PMID: 26765346Free PMC Article
Vanni D, Sirabella FS, Galzio R, Salini V, Magliani V
J Neurosurg 2015 Nov;123(5):1230-7. Epub 2015 May 29 doi: 10.3171/2014.11.JNS14901. PMID: 26024005
Kwon BC, Koh SH, Hwang SY
AJR Am J Roentgenol 2015 Jun;204(6):1248-54. doi: 10.2214/AJR.14.13371. PMID: 26001235
Tat J, Wilson KE, Keir PJ
Clin Biomech (Bristol, Avon) 2015 May;30(4):360-5. Epub 2015 Mar 2 doi: 10.1016/j.clinbiomech.2015.02.015. PMID: 25753696

Recent systematic reviews

Hu K, Zhang T, Xu W
Brain Behav 2016 Feb 16;6(3):e00439. doi: 10.1002/brb3.439. PMID: 27099801Free PMC Article
Pourmemari MH, Shiri R
Diabet Med 2016 Jan;33(1):10-6. Epub 2015 Aug 18 doi: 10.1111/dme.12855. PMID: 26173490
Chen PC, Chuang CH, Tu YK, Bai CH, Chen CF, Liaw M
BMC Musculoskelet Disord 2015 Nov 19;16:363. doi: 10.1186/s12891-015-0815-8. PMID: 26585378Free PMC Article
Shiri R, Pourmemari MH, Falah-Hassani K, Viikari-Juntura E
Obes Rev 2015 Dec;16(12):1094-104. Epub 2015 Sep 23 doi: 10.1111/obr.12324. PMID: 26395787
Franklin GM, Friedman AS
Phys Med Rehabil Clin N Am 2015 Aug;26(3):523-37. Epub 2015 Jun 19 doi: 10.1016/j.pmr.2015.04.003. PMID: 26231963

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