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Items: 3

1.

Sodium Butyrate

The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling. [from NCI]

MedGen UID:
55195
Concept ID:
C0142812
Organic Chemical; Pharmacologic Substance
2.

Coccidiostat

Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. [from MeSH]

MedGen UID:
3139
Concept ID:
C0009188
Pharmacologic Substance
3.

Salinomycin

MedGen UID:
34518
Concept ID:
C0073987
Antibiotic; Organic Chemical; Pharmacologic Substance
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