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Items: 1 to 20 of 44

1.

Infection

The invasion of an organism's body tissues by disease-causing agents and their multiplication, as well as the reaction by the host to these organisms and/or toxins that the organisms produce. [from NCI]

MedGen UID:
811352
Concept ID:
C3714514
Pathologic Function
2.

ribavirin

A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses. [from MeSH]

MedGen UID:
48459
Concept ID:
C0035525
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
3.

Hepatitis C

A viral infection caused by the hepatitis C virus. [from NCI]

MedGen UID:
42425
Concept ID:
C0019196
Disease or Syndrome
4.

Hepatitis

INFLAMMATION of the LIVER. [from MeSH]

MedGen UID:
5515
Concept ID:
C0019158
Disease or Syndrome
5.

Boceprevir

An orally bioavailable, synthetic tripeptide inhibitor of the nonstructural protein 3 and 4A complex (NS3/NS4A), with potential activity against hepatitis C virus (HCV) genotype 1. Upon administration, boceprevir reversibly binds to the active center of the HCV NS3/NS4A and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts the processing of viral proteins and the formation of a viral replication complex, which inhibits viral replication in HCV genotrype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family. [from NCI]

MedGen UID:
314899
Concept ID:
C1738934
Amino Acid, Peptide, or Protein; Pharmacologic Substance
6.

PEG Intron

MedGen UID:
316028
Concept ID:
C1527737
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
7.

Rebetol

MedGen UID:
223940
Concept ID:
C1170576
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
8.

Failures, Treatment

A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series. [from MeSH]

MedGen UID:
57953
Concept ID:
C0162643
Finding
9.

Serine

A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04) [from NCI]

MedGen UID:
11382
Concept ID:
C0036720
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
10.

Drug Toxicity

MedGen UID:
880998
Concept ID:
CN236633
Disease or Syndrome
11.

Infections

MedGen UID:
678472
Concept ID:
C0851162
Disease or Syndrome
12.

Resistance to hepatitis C virus

MedGen UID:
332112
Concept ID:
C1836031
Finding
13.

Discontinued

To stop or end, permanently or temporarily. [from NCI]

MedGen UID:
303183
Concept ID:
C1444662
Finding
14.

Hepatitis C, Chronic

INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS. [from MeSH]

MedGen UID:
105623
Concept ID:
C0524910
Disease or Syndrome
15.

Chronic

Slow, creeping onset, slow progress and long continuance of disease manifestations. [from HPO]

MedGen UID:
104657
Concept ID:
C0205191
Temporal Concept
16.

Problem

A difficulty, disorder, or condition needing resolution. [from NCI]

MedGen UID:
46106
Concept ID:
C0033213
Finding
17.

Serine proteinase inhibitor

A protein that plays a role in the inhibition of serine proteinases. [from NCI]

MedGen UID:
20708
Concept ID:
C0036733
Biologically Active Substance; Pharmacologic Substance
18.

Peptide hydrolase inhibitor

Any substance that inhibits a protease, an enzyme that breaks peptide bonds. Proteases are required for many cell processes and inhibition of proteases can inhibit viral replication, inflammatory responses, proliferation, and tumor growth. [from NCI]

MedGen UID:
18701
Concept ID:
C0033607
Pharmacologic Substance
19.

Chronic hepatitis

An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders. [from NCI]

MedGen UID:
9223
Concept ID:
C0019189
Disease or Syndrome
20.

Virazole

MedGen UID:
301227
Concept ID:
C1622085
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
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