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Resistance to hepatitis C virus(HCV)

MedGen UID:
332112
•Concept ID:
C1836031
•
Finding
Synonyms: HCV; HCV, RESISTANCE TO
 
OMIM®: 601373; 609532

Professional guidelines

PubMed

Primer on Hepatitis C Virus Resistance to Direct-Acting Antiviral Treatment: A Practical Approach for the Treating Physician.
Weisberg IS, Jacobson IM
Clin Liver Dis 2017 Nov;21(4):659-672. Epub 2017 Aug 19 doi: 10.1016/j.cld.2017.06.007. PMID: 28987254
Comprehensive Screening for Naturally Occurring Hepatitis C Virus Resistance to Direct-Acting Antivirals in the NS3, NS5A, and NS5B Genes in Worldwide Isolates of Viral Genotypes 1 to 6.
Patiño-Galindo JÁ, Salvatierra K, González-Candelas F, López-Labrador FX
Antimicrob Agents Chemother 2016 Apr;60(4):2402-16. Epub 2016 Mar 25 doi: 10.1128/AAC.02776-15. PMID: 26856832Free PMC Article
Naturally occurring substitutions conferring resistance to hepatitis C virus polymerase inhibitors in treatment-naive patients infected with genotypes 1-5.
Legrand-Abravanel F, Henquell C, Le Guillou-Guillemette H, Balan V, Mirand A, Dubois M, Lunel-Fabiani F, Payan C, Izopet J
Antivir Ther 2009;14(5):723-30. PMID: 19704176

Recent clinical studies

Etiology

Structural insights into hepatitis C virus neutralization.
Ströh LJ, Krey T
Curr Opin Virol 2023 Jun;60:101316. Epub 2023 Mar 29 doi: 10.1016/j.coviro.2023.101316. PMID: 37001334
A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.
Mazzaro C, Quartuccio L, Adinolfi LE, Roccatello D, Pozzato G, Nevola R, Tonizzo M, Gitto S, Andreone P, Gattei V
Viruses 2021 Nov 9;13(11) doi: 10.3390/v13112249. PMID: 34835054Free PMC Article
Therapy Implications of Hepatitis C Virus Genetic Diversity.
Martinez MA, Franco S
Viruses 2020 Dec 29;13(1) doi: 10.3390/v13010041. PMID: 33383891Free PMC Article
New approaches in the treatment of hepatitis C.
González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J
World J Gastroenterol 2016 Jan 28;22(4):1421-32. doi: 10.3748/wjg.v22.i4.1421. PMID: 26819511Free PMC Article
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Diagnosis

Viral hepatitis update: Progress and perspectives.
Pisano MB, Giadans CG, Flichman DM, Ré VE, Preciado MV, Valva P
World J Gastroenterol 2021 Jul 14;27(26):4018-4044. doi: 10.3748/wjg.v27.i26.4018. PMID: 34326611Free PMC Article
Resistance to DAAs: When to Look and When It Matters.
Wyles DL
Curr HIV/AIDS Rep 2017 Dec;14(6):229-237. doi: 10.1007/s11904-017-0369-5. PMID: 29116550
New approaches in the treatment of hepatitis C.
González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J
World J Gastroenterol 2016 Jan 28;22(4):1421-32. doi: 10.3748/wjg.v22.i4.1421. PMID: 26819511Free PMC Article
Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy.
Preciado MV, Valva P, Escobar-Gutierrez A, Rahal P, Ruiz-Tovar K, Yamasaki L, Vazquez-Chacon C, Martinez-Guarneros A, Carpio-Pedroza JC, Fonseca-Coronado S, Cruz-Rivera M
World J Gastroenterol 2014 Nov 21;20(43):15992-6013. doi: 10.3748/wjg.v20.i43.15992. PMID: 25473152Free PMC Article
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Therapy

Hepatitis C virus and intracellular antiviral response.
Lee J, Ou JJ
Curr Opin Virol 2022 Feb;52:244-249. Epub 2021 Dec 29 doi: 10.1016/j.coviro.2021.12.010. PMID: 34973476Free PMC Article
Therapy Implications of Hepatitis C Virus Genetic Diversity.
Martinez MA, Franco S
Viruses 2020 Dec 29;13(1) doi: 10.3390/v13010041. PMID: 33383891Free PMC Article
New approaches in the treatment of hepatitis C.
González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J
World J Gastroenterol 2016 Jan 28;22(4):1421-32. doi: 10.3748/wjg.v22.i4.1421. PMID: 26819511Free PMC Article
Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy.
Preciado MV, Valva P, Escobar-Gutierrez A, Rahal P, Ruiz-Tovar K, Yamasaki L, Vazquez-Chacon C, Martinez-Guarneros A, Carpio-Pedroza JC, Fonseca-Coronado S, Cruz-Rivera M
World J Gastroenterol 2014 Nov 21;20(43):15992-6013. doi: 10.3748/wjg.v20.i43.15992. PMID: 25473152Free PMC Article
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Prognosis

An Insight into Hepatitis C Virus: In Search of Promising Drug Targets.
Dwivedi M, Dwivedi A, Mukherjee D
Curr Drug Targets 2023;24(14):1127-1138. doi: 10.2174/0113894501265769231020031857. PMID: 37907492
Treatment Outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir in Direct-Acting Antiviral-Experienced Hepatitis C Virus Patients: A Systematic Review and Meta-Analysis.
Devan P, Tiong KLA, Neo JE, Mohan BP, Wijarnpreecha K, Tam YCS, Coppola N, Preda CM, Wong YJ
Viruses 2023 Jun 30;15(7) doi: 10.3390/v15071489. PMID: 37515176Free PMC Article
A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.
Mazzaro C, Quartuccio L, Adinolfi LE, Roccatello D, Pozzato G, Nevola R, Tonizzo M, Gitto S, Andreone P, Gattei V
Viruses 2021 Nov 9;13(11) doi: 10.3390/v13112249. PMID: 34835054Free PMC Article
Sofosbuvir and velpatasvir for the treatment of hepatitis C.
Jackson WE, Everson GT
Expert Rev Gastroenterol Hepatol 2017 Jun;11(6):501-505. Epub 2017 May 11 doi: 10.1080/17474124.2017.1326817. PMID: 28468532
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Clinical prediction guides

Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Özen A, Prachanronarong K, Matthew AN, Soumana DI, Schiffer CA
Crit Rev Biochem Mol Biol 2019 Feb;54(1):11-26. Epub 2019 Mar 1 doi: 10.1080/10409238.2019.1568962. PMID: 30821513Free PMC Article
Hepatitis C and Its Metabolic Complications in Kidney Disease.
Fabrizi F, Donato FM, Messa P
Ann Hepatol 2017 November-December,;16(6):851-861. doi: 10.5604/01.3001.0010.5275. PMID: 29055921
Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.
Bagaglio S, Uberti-Foppa C, Morsica G
Drugs 2017 Jul;77(10):1043-1055. doi: 10.1007/s40265-017-0753-x. PMID: 28497432
Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications.
Perales C, Quer J, Gregori J, Esteban JI, Domingo E
Viruses 2015 Nov 6;7(11):5746-66. doi: 10.3390/v7112902. PMID: 26561827Free PMC Article
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Recent systematic reviews

Treatment Outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir in Direct-Acting Antiviral-Experienced Hepatitis C Virus Patients: A Systematic Review and Meta-Analysis.
Devan P, Tiong KLA, Neo JE, Mohan BP, Wijarnpreecha K, Tam YCS, Coppola N, Preda CM, Wong YJ
Viruses 2023 Jun 30;15(7) doi: 10.3390/v15071489. PMID: 37515176Free PMC Article
Hepatitis C in Tunisia from 1991 to 2019: A systematic review.
Khedhiri M, Triki H, Triki H
Tunis Med 2021 Feb;99(2):189-200. PMID: 33899186Free PMC Article
Hepatitis C and Its Metabolic Complications in Kidney Disease.
Fabrizi F, Donato FM, Messa P
Ann Hepatol 2017 November-December,;16(6):851-861. doi: 10.5604/01.3001.0010.5275. PMID: 29055921
A Systematic Review of Race and Ethnicity in Hepatitis C Clinical Trial Enrollment.
Wilder J, Saraswathula A, Hasselblad V, Muir A
J Natl Med Assoc 2016 Feb;108(1):24-9. doi: 10.1016/j.jnma.2015.12.004. PMID: 26928485Free PMC Article
Hepatitis C in Children Co-infected With Human Immunodeficiency Virus.
Indolfi G, Bartolini E, Serranti D, Azzari C, Resti M
J Pediatr Gastroenterol Nutr 2015 Oct;61(4):393-9. doi: 10.1097/MPG.0000000000000895. PMID: 26147631

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