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Gene Regulatory Networks

MedGen UID:
354547
Concept ID:
C1720950
Molecular Function
Synonyms: Gene Network; Gene Networks; Gene Regulatory Network; Network, Gene; Network, Gene Regulatory; Network, Transcriptional; Networks, Gene; Networks, Gene Regulatory; Networks, Transcriptional; Regulatory Network, Gene; Regulatory Networks, Gene; Transcriptional Network; Transcriptional Networks
 

Definition

Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations. [from MeSH]

Recent clinical studies

Etiology

Fan Y, Wang X, Peng Q
Comput Math Methods Med 2017;2017:8307530. Epub 2017 Jan 4 doi: 10.1155/2017/8307530. PMID: 28133490Free PMC Article
Martin OC, Krzywicki A, Zagorski M
Phys Life Rev 2016 Jul;17:124-58. Epub 2016 Jun 23 doi: 10.1016/j.plrev.2016.06.002. PMID: 27365153
Malysheva V, Mendoza-Parra MA, Saleem MA, Gronemeyer H
Genome Med 2016 May 19;8(1):57. doi: 10.1186/s13073-016-0310-3. PMID: 27198694Free PMC Article
Arshad OA, Venkatasubramani PS, Datta A, Venkatraj J
IEEE J Biomed Health Inform 2016 Jan;20(1):399-407. Epub 2014 Nov 6 doi: 10.1109/JBHI.2014.2368391. PMID: 25389247
Willaredt MA, Schlüter T, Nothwang HG
Cell Mol Life Sci 2015 Feb;72(3):519-35. Epub 2014 Oct 21 doi: 10.1007/s00018-014-1759-0. PMID: 25332098

Diagnosis

Rogers JM
Neurogastroenterol Motil 2016 Feb;28(2):161-6. doi: 10.1111/nmo.12776. PMID: 26806097
Dincer A, Gavin DP, Xu K, Zhang B, Dudley JT, Schadt EE, Akbarian S
Transl Psychiatry 2015 Nov 17;5:e679. doi: 10.1038/tp.2015.169. PMID: 26575220Free PMC Article
de Matos Simoes R, Dalleau S, Williamson KE, Emmert-Streib F
BMC Syst Biol 2015 May 14;9:21. doi: 10.1186/s12918-015-0165-z. PMID: 25971253Free PMC Article
Baur B, Bozdag S
J Comput Biol 2015 Apr;22(4):289-99. doi: 10.1089/cmb.2014.0296. PMID: 25844668
Kim H, Gelenbe E
IEEE Trans Nanobioscience 2012 Sep;11(3):259-65. doi: 10.1109/TNB.2012.2214233. PMID: 22987132

Therapy

Arshad OA, Venkatasubramani PS, Datta A, Venkatraj J
IEEE J Biomed Health Inform 2016 Jan;20(1):399-407. Epub 2014 Nov 6 doi: 10.1109/JBHI.2014.2368391. PMID: 25389247
Dehghannasiri R, Yoon BJ, Dougherty ER
BMC Bioinformatics 2015;16 Suppl 13:S2. Epub 2015 Sep 25 doi: 10.1186/1471-2105-16-S13-S2. PMID: 26423515Free PMC Article
Wit EC, Abbruzzo A
BMC Bioinformatics 2015;16 Suppl 6:S5. Epub 2015 Apr 17 doi: 10.1186/1471-2105-16-S6-S5. PMID: 25917062Free PMC Article
Yousefi MR, Datta A, Dougherty ER
IEEE Trans Biomed Eng 2013 Dec;60(12):3542-52. Epub 2013 Jul 11 doi: 10.1109/TBME.2013.2272891. PMID: 23864151
Qian X, Dougherty ER
IEEE/ACM Trans Comput Biol Bioinform 2012 Jan-Feb;9(1):123-36. Epub 2011 Jul 20 doi: 10.1109/TCBB.2011.107. PMID: 21788674

Prognosis

Malysheva V, Mendoza-Parra MA, Saleem MA, Gronemeyer H
Genome Med 2016 May 19;8(1):57. doi: 10.1186/s13073-016-0310-3. PMID: 27198694Free PMC Article
Pemberton-Ross PJ, Pachkov M, van Nimwegen E
Methods 2015 Sep 1;85:62-74. Epub 2015 Jul 8 doi: 10.1016/j.ymeth.2015.06.024. PMID: 26164700
Wit EC, Abbruzzo A
BMC Bioinformatics 2015;16 Suppl 6:S5. Epub 2015 Apr 17 doi: 10.1186/1471-2105-16-S6-S5. PMID: 25917062Free PMC Article
Xie Y, Wang R, Zhu J
Arch Gynecol Obstet 2014 Oct;290(4):749-55. Epub 2014 Jun 3 doi: 10.1007/s00404-014-3264-y. PMID: 24890807
Zhang Y, Pu Y, Zhang H, Su Y, Zhang L, Zhou J
Comput Biol Chem 2013 Dec;47:198-206. Epub 2013 Sep 29 doi: 10.1016/j.compbiolchem.2013.09.004. PMID: 24140883

Clinical prediction guides

Malysheva V, Mendoza-Parra MA, Saleem MA, Gronemeyer H
Genome Med 2016 May 19;8(1):57. doi: 10.1186/s13073-016-0310-3. PMID: 27198694Free PMC Article
Shavit Y, Yordanov B, Dunn SJ, Wintersteiger CM, Otani T, Hamadi Y, Livesey FJ, Kugler H
Biosystems 2016 Aug;146:26-34. Epub 2016 May 10 doi: 10.1016/j.biosystems.2016.03.012. PMID: 27178783
Pemberton-Ross PJ, Pachkov M, van Nimwegen E
Methods 2015 Sep 1;85:62-74. Epub 2015 Jul 8 doi: 10.1016/j.ymeth.2015.06.024. PMID: 26164700
Xie Y, Wang R, Zhu J
Arch Gynecol Obstet 2014 Oct;290(4):749-55. Epub 2014 Jun 3 doi: 10.1007/s00404-014-3264-y. PMID: 24890807
Zhang Y, Pu Y, Zhang H, Su Y, Zhang L, Zhou J
Comput Biol Chem 2013 Dec;47:198-206. Epub 2013 Sep 29 doi: 10.1016/j.compbiolchem.2013.09.004. PMID: 24140883

Recent systematic reviews

Kao CY, Sheu BS, Wu JJ
Biomed J 2016 Feb;39(1):14-23. Epub 2016 Apr 1 doi: 10.1016/j.bj.2015.06.002. PMID: 27105595
Wruck W, Schröter F, Adjaye J
J Alzheimers Dis 2016;50(4):1065-82. doi: 10.3233/JAD-150733. PMID: 26890743
Mousavian Z, Kavousi K, Masoudi-Nejad A
Semin Cell Dev Biol 2016 Mar;51:3-13. Epub 2015 Dec 14 doi: 10.1016/j.semcdb.2015.12.007. PMID: 26701126
Tovar H, García-Herrera R, Espinal-Enríquez J, Hernández-Lemus E
Comput Biol Chem 2015 Dec;59 Pt B:67-77. Epub 2015 Aug 22 doi: 10.1016/j.compbiolchem.2015.08.007. PMID: 26362298
Yeh HY, Cheng SW, Lin YC, Yeh CY, Lin SF, Soo VW
BMC Med Genomics 2009 Dec 21;2:70. doi: 10.1186/1755-8794-2-70. PMID: 20025723Free PMC Article

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