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1.

agonists

Used with chemicals, drugs, and endogenous substances to indicate substances or agents that have affinity for a receptor and intrinsic activity at that receptor. (From Textbook of Pharmacology, 1991, p.16) [from MeSH]

MedGen UID:
116746
Concept ID:
C0243192
Pharmacologic Substance
2.

Thiazolidinediones

THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). [from MeSH]

MedGen UID:
226242
Concept ID:
C1257987
Organic Chemical; Pharmacologic Substance
3.

rosiglitazone

peroxisome proliferator activated receptor agonist; reduces lipid availability; improves insulin action and glucoregulation. [from CRISP]

MedGen UID:
129650
Concept ID:
C0289313
Organic Chemical; Pharmacologic Substance
4.

Lipid Metabolism

Functions involved in the process by which fat in the diet is stored and broken down in the body. [from ICF]

MedGen UID:
108969
Concept ID:
C0598783
Molecular Function
5.

Glucose

A type of sugar; the chief source of energy for living organisms. [from NCI_NCI-GLOSS]

MedGen UID:
42238
Concept ID:
C0017725
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
6.

pioglitazone

A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione. [from NCI_NCI-GLOSS]

MedGen UID:
20220
Concept ID:
C0071097
Organic Chemical; Pharmacologic Substance
7.

Fenofibrate

A drug used to treat high levels of cholesterol and triglycerides in the blood. Fenofibrate is being studied in the treatment of advanced cancers in young patients and in the treatment of other conditions. It is a type of antilipidemic agent. [from NCI_NCI-GLOSS]

MedGen UID:
18648
Concept ID:
C0033228
Organic Chemical; Pharmacologic Substance
8.

Heart disease

If you're like most people, you think that heart disease is a problem for others. But heart disease is the number one killer in the U.S. It is also a major cause of disability. There are many different forms of heart disease. The most common cause of heart disease is narrowing or blockage of the coronary arteries, the blood vessels that supply blood to the heart itself. This is called coronary artery disease and happens slowly over time. It's the major reason people have heart attacks. Other kinds of heart problems may happen to the valves in the heart, or the heart may not pump well and cause heart failure. Some people are born with heart disease. You can help reduce your risk of heart disease by taking steps to control factors that put you at greater risk:. - Control your blood pressure. - Lower your cholesterol. - Don't smoke. - Get enough exercise. NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

MedGen UID:
5458
Concept ID:
C0018799
Disease or Syndrome
9.

Accumulation

An increase of substance (e.g., proteinaceous fluid and glycogen) in either the intracellular space, extracellular space, or within a hollow organ or structure. [from NCI_CDISC]

MedGen UID:
883922
Concept ID:
C4055506
Finding
10.

Heart Diseases

MedGen UID:
880892
Concept ID:
CN236661
Disease or Syndrome
11.

Does not play

MedGen UID:
661018
Concept ID:
C0577490
Finding
12.

Agonist

A drug or substance that binds to a receptor inside a cell or on its surface and causes the same action as the substance that normally binds to the receptor. [from NCI_NCI-GLOSS]

MedGen UID:
459858
Concept ID:
C2987634
Pharmacologic Substance
13.

Oxidation

The process of oxidizing; the addition of oxygen to a compound accompanied by a loss of electrons. [from NCI]

MedGen UID:
18242
Concept ID:
C0030011
Molecular Function
14.

Fetal alcohol syndrome

Alcohol can harm your baby at any stage during a pregnancy. That includes the earliest stages before you even know you are pregnant. Drinking alcohol can cause a group of conditions called fetal alcohol spectrum disorders (FASDs). Effects can include physical and behavioral problems such as trouble with. -Learning and remembering. -Understanding and following directions. -Controlling emotions. -Communicating and socializing. -Daily life skills, such as feeding and bathing. Fetal alcohol syndrome is the most serious type of FASD. People with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities. FASDs last a lifetime. There is no cure for FASDs. Treatments can help. These include medicines to help with some symptoms and behavior therapy. No one treatment is right for every child. Centers for Disease Control and Prevention.  [from MedlinePlus]

MedGen UID:
8820
Concept ID:
C0015923
Disease or Syndrome
15.

Fat

The glyceryl esters of a fatty acid, or of a mixture of fatty acids. They are generally odorless, colorless, and tasteless if pure, but they may be flavored according to origin. Fats are insoluble in water, soluble in most organic solvents. They occur in animal and vegetable tissue and are generally obtained by boiling or by extraction under pressure. They are important in the diet (DIETARY FATS) as a source of energy. (Grant & Hackh's Chemical Dictionary, 5th ed) [from MeSH]

MedGen UID:
5132
Concept ID:
C0015677
Organic Chemical; Pharmacologic Substance
16.

Fenofibrat-ratiopharm

MedGen UID:
327863
Concept ID:
C1564834
Organic Chemical; Pharmacologic Substance
17.

Controlip

MedGen UID:
327836
Concept ID:
C1564718
Organic Chemical; Pharmacologic Substance
18.

Liparison

MedGen UID:
289899
Concept ID:
C1564727
Organic Chemical; Pharmacologic Substance
19.

durafenat

MedGen UID:
289896
Concept ID:
C1564719
Organic Chemical; Pharmacologic Substance
20.

Fenofanton

MedGen UID:
289029
Concept ID:
C1564744
Organic Chemical; Pharmacologic Substance
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