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Chromosomal translocation

MedGen UID:
21243
Concept ID:
C0040715
Cell or Molecular Dysfunction
Synonyms: Chromosomal Translocation; Chromosomal Translocations; Genetic Translocation; Genetic Translocations; Translocation, Chromosomal; Translocation, Genetic; Translocations, Chromosomal; Translocations, Genetic
SNOMED CT: Chromosomal translocation (15897004)
 

Definition

Any type of genetic recombination involving exchange of DNA between non-homologous chromosomes, which often occurs as the result of non-homologous end-joining of broken DNA strands. Chromosomal translocation is involved in repairing broken DNA and in maintaining cell viability at the expense of long term genomic stability. This process is is associated with particular types of leukemia, infertility and Down Syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChromosomal translocation

Recent clinical studies

Etiology

Liu C, Li B, Li L, Zhang H, Chen Y, Cui X, Hu J, Jiang J, Qi Y, Li F
Int J Clin Exp Pathol 2015;8(5):5666-73. Epub 2015 May 1 PMID: 26191279Free PMC Article
O'Meara E, Stack D, Lee CH, Garvin AJ, Morris T, Argani P, Han JS, Karlsson J, Gisselson D, Leuschner I, Gessler M, Graf N, Fletcher JA, O'Sullivan MJ
J Pathol 2012 May;227(1):72-80. Epub 2012 Feb 17 doi: 10.1002/path.3985. PMID: 22294382
Antic D, Impera L, Fekete MD, Djordjevic V, Storlazzi CT, Elezovic I
Gene 2012 Feb 1;493(1):161-4. Epub 2011 Nov 12 doi: 10.1016/j.gene.2011.11.002. PMID: 22138479
Zunino SJ, Storms DH, Ducore JM
Int J Oncol 2010 Nov;37(5):1307-13. PMID: 20878078
Cheng PJ, Chang SD, Shaw SW, Soong YK
Obstet Gynecol 2005 May;105(5 Pt 1):1058-62. doi: 10.1097/01.AOG.0000158862.84467.d7. PMID: 15863545

Diagnosis

Harada S, Sizzle E, Lin MT, Gocke CD
Clin Chem 2017 Jul;63(7):1278-1287. Epub 2017 May 17 doi: 10.1373/clinchem.2016.270140. PMID: 28515100
Higuchi M, Sasaki S, Kawadoko S, Uchiyama H, Yasui T, Kamihira T, Aoki K, Sasaguri T, Nakano R, Uchiyama A, Muta T, Ohshima K
Int J Hematol 2015 Oct;102(4):482-7. Epub 2015 May 8 doi: 10.1007/s12185-015-1802-4. PMID: 25953309
Kaneko M, Ohashi H, Takamura T, Kawame H
J Genet Couns 2015 Dec;24(6):922-30. Epub 2015 Mar 20 doi: 10.1007/s10897-015-9828-6. PMID: 25787091
Huang CC, Chang LJ, Tsai YY, Hung CC, Fang MY, Su YN, Chen HF, Chen SU
J Formos Med Assoc 2013 Sep;112(9):537-44. Epub 2013 Apr 8 doi: 10.1016/j.jfma.2013.02.010. PMID: 24079714
Cheng PJ, Chang SD, Shaw SW, Soong YK
Obstet Gynecol 2005 May;105(5 Pt 1):1058-62. doi: 10.1097/01.AOG.0000158862.84467.d7. PMID: 15863545

Therapy

Bozzetti C, Türkmen S, Richter U, Fransecky L, Bal G, Schulz CO, Hemmati P, Arnold R, Riess H, le Coutre P
J Clin Exp Hematop 2016;56(1):64-8. doi: 10.3960/jslrt.56.64. PMID: 27334861
Zhou S, Wang L, Panossian A, Anselmo D, Wu S, Venkatramani R
Pediatr Dev Pathol 2016 Sep/Oct;19(5):417-420. Epub 2015 Nov 10 doi: 10.2350/15-09-1707-CR.1. PMID: 26555222
Dela Cruz F, Matushansky I
Discov Med 2011 Oct;12(65):307-17. PMID: 22031668
Miao K, Li J, Qiu H, Zhang R, Chen L, Wu H, Wang R, Zhang J
Onkologie 2010;33(7):385-7. Epub 2010 Jun 22 doi: 10.1159/000315753. PMID: 20631486
Zunino SJ, Storms DH, Ducore JM
Cancer Lett 2010 Oct 1;296(1):49-54. Epub 2010 Apr 9 doi: 10.1016/j.canlet.2010.03.017. PMID: 20381955Free PMC Article

Prognosis

Torkildsen S, Brunetti M, Gorunova L, Spetalen S, Beiske K, Heim S, Panagopoulos I
Anticancer Res 2017 Feb;37(2):693-698. doi: 10.21873/anticanres.11365. PMID: 28179318
Bozzetti C, Türkmen S, Richter U, Fransecky L, Bal G, Schulz CO, Hemmati P, Arnold R, Riess H, le Coutre P
J Clin Exp Hematop 2016;56(1):64-8. doi: 10.3960/jslrt.56.64. PMID: 27334861
Higuchi M, Sasaki S, Kawadoko S, Uchiyama H, Yasui T, Kamihira T, Aoki K, Sasaguri T, Nakano R, Uchiyama A, Muta T, Ohshima K
Int J Hematol 2015 Oct;102(4):482-7. Epub 2015 May 8 doi: 10.1007/s12185-015-1802-4. PMID: 25953309
Boyd AS
J Cutan Pathol 2012 Sep;39(9):872-6. Epub 2012 Jul 16 doi: 10.1111/j.1600-0560.2012.01943.x. PMID: 22804337
Cheng PJ, Chang SD, Shaw SW, Soong YK
Obstet Gynecol 2005 May;105(5 Pt 1):1058-62. doi: 10.1097/01.AOG.0000158862.84467.d7. PMID: 15863545

Clinical prediction guides

Liu C, Li B, Li L, Zhang H, Chen Y, Cui X, Hu J, Jiang J, Qi Y, Li F
Int J Clin Exp Pathol 2015;8(5):5666-73. Epub 2015 May 1 PMID: 26191279Free PMC Article
Soni A, Siemann M, Grabos M, Murmann T, Pantelias GE, Iliakis G
Nucleic Acids Res 2014 Jun;42(10):6380-92. Epub 2014 Apr 19 doi: 10.1093/nar/gku298. PMID: 24748665Free PMC Article
Parent R, Plissonnier ML, Bancel B, Liao WL, Rumin S, Asaad R, Till M, Sanlaville D, Zoulim F, Trépo C, Marion MJ
J Cell Biochem 2014 Apr;115(4):666-77. doi: 10.1002/jcb.24706. PMID: 24453043
Huang CC, Chang LJ, Tsai YY, Hung CC, Fang MY, Su YN, Chen HF, Chen SU
J Formos Med Assoc 2013 Sep;112(9):537-44. Epub 2013 Apr 8 doi: 10.1016/j.jfma.2013.02.010. PMID: 24079714
Cheng PJ, Chang SD, Shaw SW, Soong YK
Obstet Gynecol 2005 May;105(5 Pt 1):1058-62. doi: 10.1097/01.AOG.0000158862.84467.d7. PMID: 15863545

Recent systematic reviews

Williams ME, Bernstein SH, Jares P, Kahl BS, Witzig TE, Gordon LI
Leuk Lymphoma 2013 Sep;54(9):1882-90. Epub 2013 Mar 4 doi: 10.3109/10428194.2013.771400. PMID: 23363271
Bell D, Hanna EY
Curr Opin Otolaryngol Head Neck Surg 2013 Apr;21(2):124-9. doi: 10.1097/MOO.0b013e32835c05fd. PMID: 23222122
Lewis JT, Oliveira AM, Nascimento AG, Schembri-Wismayer D, Moore EA, Olsen KD, Garcia JG, Lonzo ML, Lewis JE
Am J Surg Pathol 2012 Apr;36(4):517-25. doi: 10.1097/PAS.0b013e3182426886. PMID: 22301502
Louw VJ, Dreosti L, Ruff P, Jogessar V, Moodley D, Novitzky N, Patel M, Schmidt A, Willem P
S Afr Med J 2011 Nov 1;101(11):840-6. PMID: 22272968
Xu J, Wang J, Cui L, Wu X
World J Surg Oncol 2010 Nov 21;8:102. doi: 10.1186/1477-7819-8-102. PMID: 21092139Free PMC Article

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