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Items: 1 to 20 of 21

1.

Furriers lung

MedGen UID:
538594
Concept ID:
C0264476
Disease or Syndrome
2.

Coffee-workers lung

MedGen UID:
538589
Concept ID:
C0264468
Disease or Syndrome
3.

Malt-workers lung

MedGen UID:
510125
Concept ID:
C0155888
Disease or Syndrome
4.

Cheese-washers lung

MedGen UID:
507549
Concept ID:
C0007969
Disease or Syndrome
5.

Hypoplasia

Incomplete or underdevelopment of a tissue or organ. [from NCI]

MedGen UID:
537146
Concept ID:
C0243069
Pathologic Function
6.

Sildenafil

A drug used to treat erectile dysfunction. Sildenafil relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor. [from NCI_NCI-GLOSS]

MedGen UID:
102095
Concept ID:
C0529793
Organic Chemical; Pharmacologic Substance
7.

Nitric oxide

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. [from MeSH]

MedGen UID:
14378
Concept ID:
C0028128
Biologically Active Substance; Inorganic Chemical; Pharmacologic Substance
8.

Arginine

An essential amino acid in juvenile humans, Arginine is a complex amino acid, often found at active site in proteins and enzymes due to its amine-containing side chain. Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and stimulate the immune system. It also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems. Arginine is also an important intermediate in the urea cycle and in detoxification of nitrogenous wastes. (NCI04) [from NCI]

MedGen UID:
13907
Concept ID:
C0003765
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
9.

UPREG

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
12003
Concept ID:
C0041904
Molecular Function
10.

Guanosine

A purine nucleoside formed from a beta-N9-glycosidic bond between guanine and a ribose ring and is essential for metabolism. [from NCI]

MedGen UID:
9106
Concept ID:
C0018330
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
11.

Polyarteritis nodosa, childhoood-onset

Childhood-onset polyarteritis nodosa is an autosomal recessive systemic vascular inflammatory disorder characterized mainly by involvement of the skin, nervous system, kidney, and gastrointestinal tract. There is considerable variability in the severity and age at onset, although most patients have onset of symptoms in the first decade. Features include recurrent ischemic stroke affecting the small vessels of the brain and resulting in neurologic dysfunction, recurrent fever, elevated acute-phase proteins, myalgias, and livedo racemosa or reticularis with an inflammatory vasculitis on biopsy. Some patients develop hypertension, aneurysms, or ischemic necrosis of the digits (summary by Zhou et al., 2014 and Navon Elkan et al., 2014). Some patients present with clinical immunodeficiency (van Eyck et al., 2014). [from GTR]

MedGen UID:
854497
Concept ID:
C3887654
Disease or Syndrome
12.

Right

Being located on the right side of the body. [from HPO]

MedGen UID:
619189
Concept ID:
C0444532
Spatial Concept
13.

Left

Being located on the left side of the body. [from HPO]

MedGen UID:
618170
Concept ID:
C0443246
Spatial Concept
14.

Pulmonary hypoplasia

A congenital abnormality in which the lung parenchyma is not fully developed. It may be associated with other congenital abnormalities. [from NCI]

MedGen UID:
78574
Concept ID:
C0265783
Congenital Abnormality
15.

Polyarteritis nodosa

A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME. [from MeSH]

MedGen UID:
14681
Concept ID:
C0031036
Disease or Syndrome
16.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
17.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
18.

Enzyme inhibitor

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from MeSH]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
19.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
20.

NG-Nitroarginine Methyl Ester, L-Orn-Isomer, Monohydrochloride

MedGen UID:
184994
Concept ID:
C0949558
Amino Acid, Peptide, or Protein; Pharmacologic Substance
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