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Items: 11

1.

Navitoclax

An orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Navitoclax selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w, which are frequently overexpressed in a wide variety of cancers, including those of the lymph, breast, lung, prostate, and colon, and are linked to tumor drug resistance. Inhibition of these apoptosis suppressors prevents their binding to the apoptotic effectors Bax and Bak proteins, thereby triggering apoptotic processes in cells overexpressing Bcl-2, Bcl-XL, and Bcl-w. This eventually reduces tumor cell proliferation. [from NCI]

MedGen UID:
427430
Concept ID:
C2975395
Organic Chemical; Pharmacologic Substance
2.

A-855071.0

MedGen UID:
330363
Concept ID:
C1831992
Organic Chemical; Pharmacologic Substance
3.

Malignant Lung Neoplasm

A primary or metastatic malignant neoplasm involving the lung. [from NCI]

MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
4.

lung cancer

MedGen UID:
880193
Concept ID:
CN235597
Finding
5.

Small cell lung carcinoma

MedGen UID:
850987
Concept ID:
CN231771
Finding
6.

Furriers lung

MedGen UID:
538594
Concept ID:
C0264476
Disease or Syndrome
7.

Coffee-workers lung

MedGen UID:
538589
Concept ID:
C0264468
Disease or Syndrome
8.

Malt-workers lung

MedGen UID:
510125
Concept ID:
C0155888
Disease or Syndrome
9.

Cheese-washers lung

MedGen UID:
507549
Concept ID:
C0007969
Disease or Syndrome
10.

Lung cancer

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008). [from GTR]

MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
11.

Small cell lung cancer

A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA). [from MeSH]

MedGen UID:
57450
Concept ID:
C0149925
Neoplastic Process
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