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Hyperchloremic acidosis

MedGen UID:
43207
Concept ID:
C0085569
Disease or Syndrome
Synonyms: Metabolic acidosis, NAG, acidifying salts; Metabolic acidosis, normal anion gap, acidifying salts
SNOMED CT: Metabolic acidosis, normal anion gap, acidifying salts (18104000); Metabolic acidosis, NAG, acidifying salts (18104000); Hyperchloremic acidosis (18104000)
 
HPO: HP:0001995

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperchloremic acidosis

Conditions with this feature

Proximal renal tubular acidosis
MedGen UID:
82804
Concept ID:
C0268435
Disease or Syndrome
A type of renal tubular acidosis characterized by a failure of the proximal tubular cells to reabsorb bicarbonate, leading to urinary bicarbonate wasting and subsequent acidemia.
Pseudohypoaldosteronism, type 2
MedGen UID:
259599
Concept ID:
C1449844
Disease or Syndrome
Pseudohypoaldosteronism type II (PHAII) is characterized by hyperkalemia despite normal glomerular filtration rate (GFR) and frequently by hypertension. Other associated findings in both children and adults include hyperchloremia, metabolic acidosis, and suppressed plasma renin levels. Aldosterone levels are variable, but are relatively low given the degree of hyperkalemia (elevated serum potassium is a potent stimulus for aldosterone secretion). Hypercalciuria is well described.
Renal tubular acidosis, proximal, with ocular abnormalities and mental retardation
MedGen UID:
370883
Concept ID:
C1970309
Disease or Syndrome

Recent clinical studies

Etiology

Toyonaga Y, Kikura M
Nephrology (Carlton) 2017 Sep;22(9):720-727. doi: 10.1111/nep.12840. PMID: 27312130
Barker ME
J Trauma Nurs 2015 Mar-Apr;22(2):111-6. doi: 10.1097/JTN.0000000000000115. PMID: 25768968
McCague A, Dermendjieva M, Hutchinson R, Wong DT, Dao N
Scand J Trauma Resusc Emerg Med 2011 Apr 13;19:24. doi: 10.1186/1757-7241-19-24. PMID: 21486493Free PMC Article
Rehm M, Finsterer U
Anesth Analg 2003 Apr;96(4):1201-8, table of contents. PMID: 12651685
Brill SA, Stewart TR, Brundage SI, Schreiber MA
Shock 2002 Jun;17(6):459-62. PMID: 12069180

Diagnosis

Toyonaga Y, Kikura M
Nephrology (Carlton) 2017 Sep;22(9):720-727. doi: 10.1111/nep.12840. PMID: 27312130
Lepane C, Peleman R, Kinzie J
Gastroenterology 2012 Jan;142(1):e22-3. Epub 2011 Nov 19 doi: 10.1053/j.gastro.2011.01.065. PMID: 22107713
McCague A, Dermendjieva M, Hutchinson R, Wong DT, Dao N
Scand J Trauma Resusc Emerg Med 2011 Apr 13;19:24. doi: 10.1186/1757-7241-19-24. PMID: 21486493Free PMC Article
Constable PD
Anesth Analg 2003 Apr;96(4):919-22. PMID: 12651634
Brill SA, Stewart TR, Brundage SI, Schreiber MA
Shock 2002 Jun;17(6):459-62. PMID: 12069180

Therapy

Toyonaga Y, Kikura M
Nephrology (Carlton) 2017 Sep;22(9):720-727. doi: 10.1111/nep.12840. PMID: 27312130
Barker ME
J Trauma Nurs 2015 Mar-Apr;22(2):111-6. doi: 10.1097/JTN.0000000000000115. PMID: 25768968
McCague A, Dermendjieva M, Hutchinson R, Wong DT, Dao N
Scand J Trauma Resusc Emerg Med 2011 Apr 13;19:24. doi: 10.1186/1757-7241-19-24. PMID: 21486493Free PMC Article
Wille D, Hauri-Hohl M, Vonbach P, Tomaske M, Padden B, Bernet V
Eur J Pediatr 2010 Dec;169(12):1549-51. Epub 2010 Jul 13 doi: 10.1007/s00431-010-1249-9. PMID: 20625910
Rehm M, Finsterer U
Anesth Analg 2003 Apr;96(4):1201-8, table of contents. PMID: 12651685

Prognosis

Silva JM Jr, Ribas Rosa de Oliveira AM, Mendes Nogueira FA, Vianna PM, Amendola CP, Carvalho Carmona MJ, Sá Malbouisson LM
Anesth Analg 2016 Nov;123(5):1163-1171. doi: 10.1213/ANE.0000000000001575. PMID: 27644062
Ghadimi K, Gutsche JT, Setegne SL, Jackson KR, Augoustides JG, Ochroch EA, Bavaria JE, Cheung AT
J Cardiothorac Vasc Anesth 2015 Dec;29(6):1432-40. Epub 2015 Jul 29 doi: 10.1053/j.jvca.2015.07.025. PMID: 26706792
Barker ME
J Trauma Nurs 2015 Mar-Apr;22(2):111-6. doi: 10.1097/JTN.0000000000000115. PMID: 25768968
Sun B, Yan JM, Li JY, Guo HQ, Hong Q, Yao ZY, Zhou GB, Pan GX, Li XC
Urol J 2014 Jul 8;11(3):1629-35. PMID: 25015609
Brill SA, Stewart TR, Brundage SI, Schreiber MA
Shock 2002 Jun;17(6):459-62. PMID: 12069180

Clinical prediction guides

Brunner R, Drolz A, Scherzer TM, Staufer K, Fuhrmann V, Zauner C, Holzinger U, Schneeweiß B
Crit Care 2015 Apr 6;19:148. doi: 10.1186/s13054-015-0890-0. PMID: 25888397Free PMC Article
McCague A, Dermendjieva M, Hutchinson R, Wong DT, Dao N
Scand J Trauma Resusc Emerg Med 2011 Apr 13;19:24. doi: 10.1186/1757-7241-19-24. PMID: 21486493Free PMC Article
Brill SA, Stewart TR, Brundage SI, Schreiber MA
Shock 2002 Jun;17(6):459-62. PMID: 12069180
Scheingraber S, Rehm M, Sehmisch C, Finsterer U
Anesthesiology 1999 May;90(5):1265-70. PMID: 10319771
Brivet F, Bernardin M, Cherin P, Chalas J, Galanaud P, Dormont J
Intensive Care Med 1994;20(1):27-31. PMID: 8163754

Recent systematic reviews

Habbous S, Przech S, Acedillo R, Sarma S, Garg AX, Martin J
Nephrol Dial Transplant 2017 Jan 1;32(1):111-125. doi: 10.1093/ndt/gfw312. PMID: 27651467
Schindler AW, Marx G
Curr Opin Anaesthesiol 2016 Apr;29(2):158-65. doi: 10.1097/ACO.0000000000000303. PMID: 26784351
Guellec I, Gascoin G, Beuchee A, Boubred F, Tourneux P, Ramful D, Zana-Taieb E, Baud O
J Pediatr Gastroenterol Nutr 2015 Dec;61(6):605-9. doi: 10.1097/MPG.0000000000000898. PMID: 26147627

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