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Items: 15

1.

Insulin Glargine

A recombinant human insulin analog with long-acting, blood glucose-lowering activity. Insulin glargine, like regular types of human insulin, regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, thereby facilitating the cellular uptake of glucose. This lowers blood glucose levels. At the same time, insulin glargine inhibits the liver's conversion of stored glycogen into glucose, which also contributes to lower blood glucose levels. Insulin glargine also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis. (NCI05) [from NCI]

MedGen UID:
172793
Concept ID:
C0907402
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
2.

Insulin Lispro

Insulin that has been modified so that the B-chain contains a LYSINE at position 28 instead of a PROLINE and a PROLINE at position 29 instead of a LYSINE. [from MeSH]

MedGen UID:
80428
Concept ID:
C0293359
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
3.

Diabetes mellitus

Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin. With type 2 diabetes, the more common type, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood. You can also have prediabetes. This means that your blood sugar is higher than normal but not high enough to be called diabetes. Having prediabetes puts you at a higher risk of getting type 2 diabetes. Over time, having too much glucose in your blood can cause serious problems. It can damage your eyes, kidneys, and nerves. Diabetes can also cause heart disease, stroke and even the need to remove a limb. Pregnant women can also get diabetes, called gestational diabetes. A blood test can show if you have diabetes. Exercise, weight control and sticking to your meal plan can help control your diabetes. You should also monitor your glucose level and take medicine if prescribed. . NIH: National Institute of Diabetes and Digestive and Kidney Diseases.  [from MedlinePlus]

MedGen UID:
8350
Concept ID:
C0011849
Disease or Syndrome
4.

Insulin

Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. [from NCI]

MedGen UID:
5827
Concept ID:
C0021641
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
5.

Error occurred: cannot get document summary

ID:
923949

6.

Type 1 diabetes

MedGen UID:
851950
Concept ID:
CN234392
Finding
7.

Diabetes mellitus

A group of abnormalities characterized by hyperglycemia and glucose intolerance. [from HPO]

MedGen UID:
504609
Concept ID:
CN000766
Finding
8.

Spondylometaepiphyseal dysplasia short limb-hand type

MedGen UID:
338595
Concept ID:
C1849011
Disease or Syndrome
9.

Type I diabetes mellitus

MedGen UID:
334999
Concept ID:
C1844664
Finding
10.

Diabetes mellitus type 1

The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian populations (Todd, 1990). Genetic studies of IDDM have focused on the identification of loci associated with increased susceptibility to this multifactorial phenotype. The classical phenotype of diabetes mellitus is polydipsia, polyphagia, and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. [from OMIM]

MedGen UID:
41522
Concept ID:
C0011854
Disease or Syndrome
11.

Basaglar

MedGen UID:
905395
Concept ID:
C4081042
Amino Acid, Peptide, or Protein; Pharmacologic Substance
12.

Insulin, Short-Acting

Insulin derivatives and preparations that are designed to induce a rapid HYPOGLYCEMIC EFFECT. [from MeSH]

MedGen UID:
452462
Concept ID:
C0356365
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
13.

Lantus

A drug used to control the amount of sugar in the blood of patients with diabetes. It is a form of the hormone insulin that is made in the laboratory. Insulin glargine controls blood sugar longer than insulin does. It is a type of therapeutic insulin. [from NCI]

MedGen UID:
209072
Concept ID:
C0876064
Amino Acid, Peptide, or Protein; Pharmacologic Substance
14.

Humalog

MedGen UID:
101953
Concept ID:
C0528249
Amino Acid, Peptide, or Protein; Pharmacologic Substance
15.

46,XY sex reversal 8

MedGen UID:
333416
Concept ID:
C1839840
Disease or Syndrome
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