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Stomach cancer

MedGen UID:
147066
Concept ID:
C0699791
Neoplastic Process
Synonyms: Gastric cancer
SNOMED CT: Carcinoma of stomach (372143007); Gastric carcinoma (372143007)
 
OMIM®: 613659
HPO: HP:0012126
Orphanet: ORPHA423771

Definition

A cancer arising in any part of the stomach. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStomach cancer
Follow this link to review classifications for Stomach cancer in Orphanet.

Conditions with this feature

Neoplasm of stomach
MedGen UID:
20958
Concept ID:
C0038356
Neoplastic Process
In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), and the Li-Fraumeni syndrome (151623). See also hereditary diffuse gastric cancer (HDGC; 137215). Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263).
Hereditary diffuse gastric cancer
MedGen UID:
310839
Concept ID:
C1708349
Neoplastic Process
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant susceptibility for diffuse gastric cancer, a poorly differentiated adenocarcinoma that infiltrates into the stomach wall causing thickening of the wall (linitis plastica) without forming a distinct mass. Diffuse gastric cancer is also referred to as signet ring carcinoma or isolated cell-type carcinoma. The average age of onset of HDGC is 38 years (range: 14-69 years). The majority of the cancers in individuals with a CDH1 pathogenic variant occur before age 40 years. The estimated cumulative risk of gastric cancer by age 80 years is 70% for men and 56% for women. Women are also at a 42% risk for lobular breast cancer.
Li-Fraumeni syndrome 2
MedGen UID:
322930
Concept ID:
C1836482
Disease or Syndrome
Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults.The cancers most often associated with Li-Fraumeni syndrome include breast cancer, a form of bone cancer called osteosarcoma, and cancers of soft tissues (such as muscle) called soft tissue sarcomas. Other cancers commonly seen in this syndrome include brain tumors, cancers of blood-forming tissues (leukemias), and a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands (small hormone-producing glands on top of each kidney). Several other types of cancer also occur more frequently in people with Li-Fraumeni syndrome.A very similar condition called Li-Fraumeni-like syndrome shares many of the features of classic Li-Fraumeni syndrome. Both conditions significantly increase the chances of developing multiple cancers beginning in childhood; however, the pattern of specific cancers seen in affected family members is different.
Familial adenomatous polyposis 4
MedGen UID:
934686
Concept ID:
C4310719
Disease or Syndrome
Familial adenomatous polyposis-4 is an autosomal recessive tumor predisposition syndrome characterized by the development of multiple colonic adenomas in adulthood, often with progression to colorectal cancer. Proliferative lesions in other tissues may also occur (summary by Adam et al., 2016). For a discussion of genetic heterogeneity of familial adenomatous polyposis, see FAP1 (175100).

Recent clinical studies

Etiology

Jim MA, Pinheiro PS, Carreira H, Espey DK, Wiggins CL, Weir HK
Cancer 2017 Dec 15;123 Suppl 24:4994-5013. doi: 10.1002/cncr.30881. PMID: 29205310Free PMC Article
Ellison-Loschmann L, Sporle A, Corbin M, Cheng S, Harawira P, Gray M, Whaanga T, Guilford P, Koea J, Pearce N
PLoS One 2017;12(7):e0181581. Epub 2017 Jul 21 doi: 10.1371/journal.pone.0181581. PMID: 28732086Free PMC Article
Chen YZ, Guo F, Sun HW, Kong HR, Dai SJ, Huang SH, Zhu WW, Yang WJ, Zhou MT
J Cell Mol Med 2016 May;20(5):903-8. Epub 2016 Jan 28 doi: 10.1111/jcmm.12773. PMID: 26820236Free PMC Article
Wada K, Tsuji M, Tamura T, Konishi K, Kawachi T, Hori A, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C
Int J Cancer 2015 Aug 15;137(4):885-92. Epub 2015 Feb 3 doi: 10.1002/ijc.29437. PMID: 25639758
Xu HL, Tan YT, Epplein M, Li HL, Gao J, Gao YT, Zheng W, Shu XO, Xiang YB
Cancer Sci 2015 Mar;106(3):294-8. Epub 2015 Jan 28 doi: 10.1111/cas.12597. PMID: 25557005Free PMC Article

Diagnosis

Jim MA, Pinheiro PS, Carreira H, Espey DK, Wiggins CL, Weir HK
Cancer 2017 Dec 15;123 Suppl 24:4994-5013. doi: 10.1002/cncr.30881. PMID: 29205310Free PMC Article
Chen YZ, Guo F, Sun HW, Kong HR, Dai SJ, Huang SH, Zhu WW, Yang WJ, Zhou MT
J Cell Mol Med 2016 May;20(5):903-8. Epub 2016 Jan 28 doi: 10.1111/jcmm.12773. PMID: 26820236Free PMC Article
Meng DQ, Li PL, Xie M
Genet Mol Res 2015 May 22;14(2):5346-54. doi: 10.4238/2015.May.22.5. PMID: 26125731
Minami Y, Kawai M, Fujiya T, Suzuki M, Noguchi T, Yamanami H, Kakugawa Y, Nishino Y
Int J Cancer 2015 Jan 15;136(2):411-24. Epub 2014 Jun 17 doi: 10.1002/ijc.29001. PMID: 24890283
Ma YM, Ba CF, Wang YB
J Clin Nurs 2014 May;23(9-10):1257-62. Epub 2013 Sep 5 doi: 10.1111/jocn.12311. PMID: 24033817

Therapy

Ellison-Loschmann L, Sporle A, Corbin M, Cheng S, Harawira P, Gray M, Whaanga T, Guilford P, Koea J, Pearce N
PLoS One 2017;12(7):e0181581. Epub 2017 Jul 21 doi: 10.1371/journal.pone.0181581. PMID: 28732086Free PMC Article
Messier KP, Serre ML
Int J Epidemiol 2017 Apr 1;46(2):676-685. doi: 10.1093/ije/dyw128. PMID: 27639278Free PMC Article
Zayeri F, Mansouri A, Sheidaei A, Rahimzadeh S, Rezaei N, Modirian M, Khademioureh S, Baghestani AR, Farzadfar F
Asian Pac J Cancer Prev 2016;17(2):661-5. PMID: 26925660
Wada K, Tsuji M, Tamura T, Konishi K, Kawachi T, Hori A, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C
Int J Cancer 2015 Aug 15;137(4):885-92. Epub 2015 Feb 3 doi: 10.1002/ijc.29437. PMID: 25639758
Malakar M, Devi KR, Phukan RK, Kaur T, Deka M, Puia L, Baruah D, Mahanta J, Narain K
Asian Pac J Cancer Prev 2014;15(20):8815-22. PMID: 25374213

Prognosis

Ellison-Loschmann L, Sporle A, Corbin M, Cheng S, Harawira P, Gray M, Whaanga T, Guilford P, Koea J, Pearce N
PLoS One 2017;12(7):e0181581. Epub 2017 Jul 21 doi: 10.1371/journal.pone.0181581. PMID: 28732086Free PMC Article
Zayeri F, Mansouri A, Sheidaei A, Rahimzadeh S, Rezaei N, Modirian M, Khademioureh S, Baghestani AR, Farzadfar F
Asian Pac J Cancer Prev 2016;17(2):661-5. PMID: 26925660
Putthanachote N, Promthet S, Suwanrungruan K, Chopjitt P, Wiangnon S, Chen LS, Yen MF, Chen TH
Asian Pac J Cancer Prev 2015;16(14):6111-6. PMID: 26320504
Minami Y, Kawai M, Fujiya T, Suzuki M, Noguchi T, Yamanami H, Kakugawa Y, Nishino Y
Int J Cancer 2015 Jan 15;136(2):411-24. Epub 2014 Jun 17 doi: 10.1002/ijc.29001. PMID: 24890283
Ma YM, Ba CF, Wang YB
J Clin Nurs 2014 May;23(9-10):1257-62. Epub 2013 Sep 5 doi: 10.1111/jocn.12311. PMID: 24033817

Clinical prediction guides

Jim MA, Pinheiro PS, Carreira H, Espey DK, Wiggins CL, Weir HK
Cancer 2017 Dec 15;123 Suppl 24:4994-5013. doi: 10.1002/cncr.30881. PMID: 29205310Free PMC Article
Chen YZ, Guo F, Sun HW, Kong HR, Dai SJ, Huang SH, Zhu WW, Yang WJ, Zhou MT
J Cell Mol Med 2016 May;20(5):903-8. Epub 2016 Jan 28 doi: 10.1111/jcmm.12773. PMID: 26820236Free PMC Article
Wada K, Tsuji M, Tamura T, Konishi K, Kawachi T, Hori A, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C
Int J Cancer 2015 Aug 15;137(4):885-92. Epub 2015 Feb 3 doi: 10.1002/ijc.29437. PMID: 25639758
Minami Y, Kawai M, Fujiya T, Suzuki M, Noguchi T, Yamanami H, Kakugawa Y, Nishino Y
Int J Cancer 2015 Jan 15;136(2):411-24. Epub 2014 Jun 17 doi: 10.1002/ijc.29001. PMID: 24890283
Ma YM, Ba CF, Wang YB
J Clin Nurs 2014 May;23(9-10):1257-62. Epub 2013 Sep 5 doi: 10.1111/jocn.12311. PMID: 24033817

Recent systematic reviews

Seo GH, Kang HY, Choe EK
Medicine (Baltimore) 2018 Apr;97(17):e0532. doi: 10.1097/MD.0000000000010532. PMID: 29703028Free PMC Article
Peng WJ, Jia XJ, Wei BG, Yang LS, Yu Y, Zhang L
J Cancer Res Clin Oncol 2015 Jul;141(7):1141-9. Epub 2014 Aug 13 doi: 10.1007/s00432-014-1791-3. PMID: 25115694
Arnold M, Moore SP, Hassler S, Ellison-Loschmann L, Forman D, Bray F
Gut 2014 Jan;63(1):64-71. Epub 2013 Oct 23 doi: 10.1136/gutjnl-2013-305033. PMID: 24153248
Shu L, Wang XQ, Wang SF, Wang S, Mu M, Zhao Y, Sheng J, Tao FB
Nutr Cancer 2013;65(8):1105-15. Epub 2013 Oct 29 doi: 10.1080/01635581.2013.828086. PMID: 24168194
Jarl J, Heckley G, Brummer J, Gerdtham UG
BMC Public Health 2013 Jun 20;13:600. doi: 10.1186/1471-2458-13-600. PMID: 23786883Free PMC Article

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