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Items: 4

1.

Frequency

MedGen UID:
91210
Concept ID:
C0376249
Temporal Concept
2.

Equol

A non-steroidal ESTROGEN generated when soybean products are metabolized by certain bacteria in the intestines. [from MeSH]

MedGen UID:
29972
Concept ID:
C0059497
Organic Chemical; Pharmacologic Substance
3.

Isoflavone

A class of polyphenolic compounds derived from the Fabaceae family with potential phytoestrogenic, cholesterol-reducing, chemotherapeutic and antioxidant activity. In isoflavones the phenyl group on the benzopyran ring is in position 3 relative to the oxygen of the ring. Most isoflavones for human consumption and that are currently studied are derived from soy beans. [from NCI]

MedGen UID:
7168
Concept ID:
C0022179
Organic Chemical; Pharmacologic Substance
4.

S-equol

An orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER. [from NCI]

MedGen UID:
856539
Concept ID:
C3896945
Hormone; Organic Chemical; Pharmacologic Substance
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