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Acetaminophen

MedGen UID:
1276
Concept ID:
C0000970
Organic Chemical; Pharmacologic Substance
Synonyms: Acetamide, N-(4-hydroxyphenyl)-; Acetamidophenol; Acetominophen; APAP; Hydroxyacetanilide; N-(4-Hydroxyphenyl)acetanilide; N-Acetyl-p-aminophenol; p-Acetamidophenol; p-Hydroxyacetanilide; Paracetamol
Drug response:
Acetaminophen response
MedGen UID:
450496
Concept ID:
CN078024
Sign or Symptom
SNOMED CT: Acetaminophen (387517004); Acetaminophen product (90332006); Paracetamol (90332006); Acetaminophen (90332006)
 

Definition

A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, acetaminophen may inhibit the nitric oxide (NO) pathway mediated by a variety of neurotransmitter receptors including N-methyl-D-aspartate (NMDA) and substance P, resulting in elevation of the pain threshold. The antipyretic activity may result from inhibition of prostaglandin synthesis and release in the central nervous system (CNS) and prostaglandin-mediated effects on the heat-regulating center in the anterior hypothalamus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcetaminophen

Recent clinical studies

Etiology

Levine M, Stellpflug S, Pizon AF, Traub S, Vohra R, Wiegand T, Traub N, Tashman D, Desai S, Chang J, Nathwani D, Thomas S
Clin Toxicol (Phila) 2017 Jul;55(6):569-572. Epub 2017 Mar 1 doi: 10.1080/15563650.2017.1291945. PMID: 28489461
Politi JR, Davis RL 2nd, Matrka AK
J Arthroplasty 2017 Apr;32(4):1125-1127. Epub 2016 Oct 21 doi: 10.1016/j.arth.2016.10.018. PMID: 27839957
Yarema MC, Green JP, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Spyker DA, Rumack BH
Clin Toxicol (Phila) 2017 Feb;55(2):102-108. Epub 2016 Oct 28 doi: 10.1080/15563650.2016.1247959. PMID: 27788602
Weiss NS
Cancer Causes Control 2016 Dec;27(12):1411-1418. Epub 2016 Nov 10 doi: 10.1007/s10552-016-0818-2. PMID: 27832383Free PMC Article
Hong YM, Yoon KT, Heo J, Woo HY, Lim W, An DS, Han JH, Cho M
J Korean Med Sci 2016 Oct;31(10):1604-10. doi: 10.3346/jkms.2016.31.10.1604. PMID: 27550489Free PMC Article

Diagnosis

Yarema MC, Green JP, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Spyker DA, Rumack BH
Clin Toxicol (Phila) 2017 Feb;55(2):102-108. Epub 2016 Oct 28 doi: 10.1080/15563650.2016.1247959. PMID: 27788602
Hong YM, Yoon KT, Heo J, Woo HY, Lim W, An DS, Han JH, Cho M
J Korean Med Sci 2016 Oct;31(10):1604-10. doi: 10.3346/jkms.2016.31.10.1604. PMID: 27550489Free PMC Article
Simental-Mendía M, Vílchez-Cavazos JF, Peña-Martínez VM, Said-Fernández S, Lara-Arias J, Martínez-Rodríguez HG
Arch Orthop Trauma Surg 2016 Dec;136(12):1723-1732. Epub 2016 Aug 9 doi: 10.1007/s00402-016-2545-2. PMID: 27506585
Daneshinejad H, Chamjangali MA, Goudarzi N, Roudbari A
Mater Sci Eng C Mater Biol Appl 2016 Jan 1;58:532-40. Epub 2015 Aug 31 doi: 10.1016/j.msec.2015.08.044. PMID: 26478341
Cook SF, King AD, van den Anker JN, Wilkins DG
J Chromatogr B Analyt Technol Biomed Life Sci 2015 Dec 15;1007:30-42. Epub 2015 Oct 31 doi: 10.1016/j.jchromb.2015.10.013. PMID: 26571452

Therapy

Levine M, Stellpflug S, Pizon AF, Traub S, Vohra R, Wiegand T, Traub N, Tashman D, Desai S, Chang J, Nathwani D, Thomas S
Clin Toxicol (Phila) 2017 Jul;55(6):569-572. Epub 2017 Mar 1 doi: 10.1080/15563650.2017.1291945. PMID: 28489461
Politi JR, Davis RL 2nd, Matrka AK
J Arthroplasty 2017 Apr;32(4):1125-1127. Epub 2016 Oct 21 doi: 10.1016/j.arth.2016.10.018. PMID: 27839957
Yarema MC, Green JP, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Spyker DA, Rumack BH
Clin Toxicol (Phila) 2017 Feb;55(2):102-108. Epub 2016 Oct 28 doi: 10.1080/15563650.2016.1247959. PMID: 27788602
Hashiba KA, Wo SR, Yamamoto LG
Clin Pediatr (Phila) 2017 Feb;56(2):146-149. Epub 2016 Jul 19 doi: 10.1177/0009922816657151. PMID: 27369430
Weiss NS
Cancer Causes Control 2016 Dec;27(12):1411-1418. Epub 2016 Nov 10 doi: 10.1007/s10552-016-0818-2. PMID: 27832383Free PMC Article

Prognosis

Yarema MC, Green JP, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Spyker DA, Rumack BH
Clin Toxicol (Phila) 2017 Feb;55(2):102-108. Epub 2016 Oct 28 doi: 10.1080/15563650.2016.1247959. PMID: 27788602
Weiss NS
Cancer Causes Control 2016 Dec;27(12):1411-1418. Epub 2016 Nov 10 doi: 10.1007/s10552-016-0818-2. PMID: 27832383Free PMC Article
Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W; NIH/NHLBI AsthmaNet.
N Engl J Med 2016 Aug 18;375(7):619-30. doi: 10.1056/NEJMoa1515990. PMID: 27532828Free PMC Article
Liu X, Liew Z, Olsen J, Pedersen LH, Bech BH, Agerbo E, Yuan W, Li J
Pharmacoepidemiol Drug Saf 2016 Feb;25(2):188-95. Epub 2015 Dec 16 doi: 10.1002/pds.3940. PMID: 26676925
Hartman JH, Letzig LG, Roberts DW, James LP, Fifer EK, Miller GP
Biochem Pharmacol 2015 Oct 1;97(3):341-9. Epub 2015 Jul 28 doi: 10.1016/j.bcp.2015.07.026. PMID: 26225832

Clinical prediction guides

Politi JR, Davis RL 2nd, Matrka AK
J Arthroplasty 2017 Apr;32(4):1125-1127. Epub 2016 Oct 21 doi: 10.1016/j.arth.2016.10.018. PMID: 27839957
Yarema MC, Green JP, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Spyker DA, Rumack BH
Clin Toxicol (Phila) 2017 Feb;55(2):102-108. Epub 2016 Oct 28 doi: 10.1080/15563650.2016.1247959. PMID: 27788602
Weiss NS
Cancer Causes Control 2016 Dec;27(12):1411-1418. Epub 2016 Nov 10 doi: 10.1007/s10552-016-0818-2. PMID: 27832383Free PMC Article
Hosseinzadeh Nik T, Shahsavari N, Ghadirian H, Ostad SN
Acta Med Iran 2016 Jul;54(7):418-21. PMID: 27424011
Stoudenmire LG, Norman CM, Latif EZ
J Pharm Pract 2016 Oct;29(5):475-9. Epub 2015 Feb 8 doi: 10.1177/0897190014568384. PMID: 25660585

Recent systematic reviews

Ennis ZN, Dideriksen D, Vaegter HB, Handberg G, Pottegård A
Basic Clin Pharmacol Toxicol 2016 Mar;118(3):184-9. Epub 2015 Dec 28 doi: 10.1111/bcpt.12527. PMID: 26572078
Hoover RM, Hayes VA, Erramouspe J
Ann Pharmacother 2015 Dec;49(12):1357-61. Epub 2015 Sep 23 doi: 10.1177/1060028015606469. PMID: 26400006
Franke RM, Morton T, Devarakonda K
Drug Des Devel Ther 2015;9:4587-97. Epub 2015 Aug 11 doi: 10.2147/DDDT.S79499. PMID: 26316698Free PMC Article
Caldeira D, Costa J, Barra M, Pinto FJ, Ferreira JJ
Thromb Res 2015 Jan;135(1):58-61. Epub 2014 Oct 22 doi: 10.1016/j.thromres.2014.10.011. PMID: 25456003
Le J, Gales MA, Gales BJ
Ann Pharmacother 2015 Feb;49(2):241-6. Epub 2014 Oct 28 doi: 10.1177/1060028014557564. PMID: 25352038

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