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Items: 4

1.

Protein binding

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. [from MeSH]

MedGen UID:
18704
Concept ID:
C0033618
Molecular Function
2.

Alkaloid

A family or group of nitrogen-containing base compounds primarily derived from plant and animal sources. Many alkaloids are used medicinally, including cancer therapy. [from NCI]

MedGen UID:
7968
Concept ID:
C0002062
Organic Chemical; Pharmacologic Substance
3.

Alpha-fetoprotein deficiency

Alpha-fetoprotein deficiency appears to be a benign genetic trait (Greenberg et al., 1992; Sharony et al., 2004). [from GTR]

MedGen UID:
354899
Concept ID:
C1863081
Disease or Syndrome
4.

Extracellular Matrix Binding Pathway

Activation of the MAPK kinase pathway has been identified as a mechanism that integrins use to regulate gene expression, leading to cell shape changes during cell spreading or migration. Epithelial cells respond to extracellular matrix (ECM) causing integrin-mediated FAK phosphorylation; this, in turn, phosphorylates the surrounding proteins (paxillin, Fyn/shc, and src) and leads to signal amplification. FAK also binds PI-3 kinase and acts upstream in the MAP kinase pathway. When MAP kinase or PI-3 kinase is inhibited, actin reorganization is blocked. Src phosphorylates p190RhoGAP, inactivating its GAP function and allowing RhoGTP to stay active longer, promoting further signal amplification. Activated RhoGTP binds to downstream kinases such as Rho-associated coiled coil-containing protein kinase (p160ROCK) and p140 diaphanous (p140Dia) to increase actin polymerization and contraction. Actin reorganization assists integrin clustering, allowing more ECM binding that increase FAK phosphorylation and other signal transduction events. [from NCI_BioC]

MedGen UID:
273277
Concept ID:
C1517051
Molecular Function
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