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Severe

MedGen UID:
104640
Concept ID:
C0205082
Qualitative Concept
Synonyms: Gravis; High Grade; High grade; Major; Severe (severity modifier); Severely
SNOMED CT: Severe (severity modifier) (24484000); Severe (24484000); High grade (24484000); Gravis (24484000); Severely (24484000); Major (24484000)
 
HPO: HP:0012828

Definition

Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean. [from HPO]

Recent systematic reviews

Deng Q, Fang X, Zeng Q, Lu J, Jing C, Huang J
An Bras Dermatol 2017 May-Jun;92(3):345-349. doi: 10.1590/abd1806-4841.20175171. PMID: 29186246Free PMC Article
Sypniewska P, Duda JF, Locatelli I, Althaus CR, Althaus F, Genton B
BMC Med 2017 Aug 3;15(1):147. doi: 10.1186/s12916-017-0906-5. PMID: 28768513Free PMC Article
Hindryckx P, Novak G, Vande Casteele N, Laukens D, Parker C, Shackelton LM, Narula N, Khanna R, Dulai P, Levesque BG, Sandborn WJ, D'Haens G, Feagan BG, Jairath V
Aliment Pharmacol Ther 2017 Mar;45(5):617-630. Epub 2017 Jan 11 doi: 10.1111/apt.13913. PMID: 28074618
Komaki Y, Komaki F, Micic D, Yamada A, Suzuki Y, Sakuraba A
J Gastroenterol Hepatol 2017 Jun;32(6):1143-1151. doi: 10.1111/jgh.13674. PMID: 27957761
Jara LJ, García-Collinot G, Medina G, Cruz-Dominguez MDP, Vera-Lastra O, Carranza-Muleiro RA, Saavedra MA
Immunol Res 2017 Feb;65(1):8-16. doi: 10.1007/s12026-016-8811-0. PMID: 27412294

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