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Items: 1 to 20 of 27

1.

Clopidogrel

a kind of anti-clotting drug [from CHV]

MedGen UID:
32948
Concept ID:
C0070166
Organic Chemical; Pharmacologic Substance
2.

Thrombosis

The formation or presence of a thrombus (blood clot) inside a blood vessel. [from NCI]

MedGen UID:
21160
Concept ID:
C0040053
Pathologic Function
3.

Stent Thrombosis

The formation of a blood clot of a vessel or heart chamber after and due to the placement of a stent. [from NCI]

MedGen UID:
857087
Concept ID:
C3897493
Disease or Syndrome; Pathologic Function
4.

Clopidogrel response

Clopidogrel is a thienopyridine antiplatelet agent that prevents platelet activation and aggregation by irreversibly inhibiting the P2Y12 ADP receptors. As a pro-drug, clopidogrel requires hepatic biotransformation to form an active metabolite. This conversion is composed of two sequential oxidative steps, which involve cytochrome P450-2C19 (CYP2C19) and other enzymes. Genetic variants in CYP2C19 such as CYP2C19*2, along with other genetic and non-genetic factors, are known to influence variability in clopidogrel response. Specific CYP2C19 variants impair formation of the active clopidogrel metabolite, which results in reduced platelet inhibition. Among clopidogrel-treated patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary intervention (PCI), patients with specific variants in the CYP2C19 gene might be at increased risk for serious adverse cardiovascular events and may benefit from an alternative antiplatelet therapy as compared to patients without these variants. Guidelines regarding the use of pharmacogenomic tests in dosing for clopidogrel have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and are available on the PharmGKB website. [from PharmGKB]

MedGen UID:
382487
Concept ID:
C2674941
Disease or Syndrome
5.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
6.

der(1;16)(q10;p10)

MedGen UID:
272927
Concept ID:
C1515617
Cell or Molecular Dysfunction
7.

Thienopyridines

A class of agents that target at platelet ADP receptor or purinergic receptor P2RY12 with antiplatelet activity. [from NCI]

MedGen UID:
423565
Concept ID:
C2936588
Organic Chemical; Pharmacologic Substance
8.

Ticlodone

MedGen UID:
196501
Concept ID:
C0733420
Organic Chemical; Pharmacologic Substance
9.

Ticlid

MedGen UID:
196500
Concept ID:
C0733418
Organic Chemical; Pharmacologic Substance
10.

53-32C

MedGen UID:
152716
Concept ID:
C0733417
Organic Chemical; Pharmacologic Substance
11.

Ticlodix

MedGen UID:
149130
Concept ID:
C0733419
Organic Chemical; Pharmacologic Substance
12.

vessel (polysaccharide)

MedGen UID:
56099
Concept ID:
C0148346
Carbohydrate; Organic Chemical; Pharmacologic Substance
13.

Thrombus

MedGen UID:
43439
Concept ID:
C0087086
Disease or Syndrome; Pathologic Function
14.

Embolism and Thrombosis

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
43147
Concept ID:
C0085307
Disease or Syndrome
15.

Vascular disorder

The vascular system is the body's network of blood vessels. It includes the arteries, veins and capillaries that carry blood to and from the heart. Problems of the vascular system are common and can be serious. Arteries can become thick and stiff, a problem called atherosclerosis. Blood clots can clog vessels and block blood flow to the heart or brain. Weakened blood vessels can burst, causing bleeding inside the body. . You are more likely to have vascular disease as you get older. Other factors that make vascular disease more likely include. - Family history of vascular or heart diseases. - Pregnancy. - Illness or injury . - Long periods of sitting or standing still. - Any condition that affects the heart and blood vessels, such as diabetes or high cholesterol . - Smoking . - Obesity . Losing weight, eating healthy foods, being active and not smoking can help vascular disease. Other treatments include medicines and surgery.  [from MedlinePlus]

MedGen UID:
22621
Concept ID:
C0042373
Disease or Syndrome
16.

Vascular Surgical Procedures

Operative procedures for the treatment of vascular disorders. [from MeSH]

MedGen UID:
21830
Concept ID:
C0042381
Therapeutic or Preventive Procedure
17.

Ticlopidine

An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES. [from MeSH]

MedGen UID:
21180
Concept ID:
C0040207
Organic Chemical; Pharmacologic Substance
18.

Platelet Aggregation Inhibitors

drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. [from CRISP]

MedGen UID:
19348
Concept ID:
C0032177
Pharmacologic Substance
19.

Postoperative complication

Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. [from MeSH]

MedGen UID:
10871
Concept ID:
C0032787
Pathologic Function
20.

Hematologic Agents

Drugs that act on blood and blood-forming organs and those that affect the hemostatic system. [from MeSH]

MedGen UID:
9187
Concept ID:
C0018938
Pharmacologic Substance
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