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T-Cell Antigen Receptor Specificity

MedGen UID:
210169
Concept ID:
C1136158
Molecular Function
Synonyms: Specificity, T-Cell Receptor; T Cell Antigen Receptor Specificity; T Cell Receptor Specificity; T-Cell Receptor Specificity
 

Definition

The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule. [from MeSH]

Recent clinical studies

Etiology

Bruder Costa J, Dufeu-Duchesne T, Leroy V, Bertucci I, Bouvier-Alias M, Pouget N, Brevot-Lutton O, Bourliere M, Zoulim F, Plumas J, Aspord C; ANRS HB06 PEGAN study group.
PLoS One 2016;11(6):e0158297. Epub 2016 Jun 27 doi: 10.1371/journal.pone.0158297. PMID: 27348813Free PMC Article
Dellabona P, Consonni M, de Lalla C, Casorati G
Tissue Antigens 2015 Dec;86(6):393-405. Epub 2015 Oct 30 doi: 10.1111/tan.12689. PMID: 26514448
Calarota SA, Aberle JH, Puchhammer-Stöckl E, Baldanti F
J Clin Virol 2015 Sep;70:109-19. Epub 2015 Jul 26 doi: 10.1016/j.jcv.2015.07.299. PMID: 26305832
van den Berg JH, Gomez-Eerland R, van de Wiel B, Hulshoff L, van den Broek D, Bins A, Tan HL, Harper JV, Hassan NJ, Jakobsen BK, Jorritsma A, Blank CU, Schumacher TN, Haanen JB
Mol Ther 2015 Sep;23(9):1541-50. Epub 2015 Apr 21 doi: 10.1038/mt.2015.60. PMID: 25896248Free PMC Article
Humphreys IS, von Delft A, Brown A, Hibbert L, Collier JD, Foster GR, Rahman M, Christian A, Klenerman P, Barnes E
Gut 2012 Nov;61(11):1589-99. Epub 2012 Feb 15 doi: 10.1136/gutjnl-2011-300650. PMID: 22337948Free PMC Article

Diagnosis

Klinger M, Pepin F, Wilkins J, Asbury T, Wittkop T, Zheng J, Moorhead M, Faham M
PLoS One 2015;10(10):e0141561. Epub 2015 Oct 28 doi: 10.1371/journal.pone.0141561. PMID: 26509579Free PMC Article
Bidmon N, Attig S, Rae R, Schröder H, Omokoko TA, Simon P, Kuhn AN, Kreiter S, Sahin U, Gouttefangeas C, van der Burg SH, Britten CM
J Immunol 2015 Jun 15;194(12):6177-89. Epub 2015 May 8 doi: 10.4049/jimmunol.1400958. PMID: 25957167
Humphreys IS, von Delft A, Brown A, Hibbert L, Collier JD, Foster GR, Rahman M, Christian A, Klenerman P, Barnes E
Gut 2012 Nov;61(11):1589-99. Epub 2012 Feb 15 doi: 10.1136/gutjnl-2011-300650. PMID: 22337948Free PMC Article
Mahler M, Fritzler MJ
Ann N Y Acad Sci 2010 Jan;1183:267-87. doi: 10.1111/j.1749-6632.2009.05127.x. PMID: 20146721
van den Berg HA, Wooldridge L, Laugel B, Sewell AK
J Theor Biol 2007 Nov 21;249(2):395-408. Epub 2007 Aug 8 doi: 10.1016/j.jtbi.2007.08.002. PMID: 17869274

Therapy

Bruder Costa J, Dufeu-Duchesne T, Leroy V, Bertucci I, Bouvier-Alias M, Pouget N, Brevot-Lutton O, Bourliere M, Zoulim F, Plumas J, Aspord C; ANRS HB06 PEGAN study group.
PLoS One 2016;11(6):e0158297. Epub 2016 Jun 27 doi: 10.1371/journal.pone.0158297. PMID: 27348813Free PMC Article
Whilding LM, Maher J
Immunotherapy 2015;7(3):229-41. doi: 10.2217/imt.14.120. PMID: 25804476
Blankenstein T, Leisegang M, Uckert W, Schreiber H
Curr Opin Immunol 2015 Apr;33:112-9. Epub 2015 Feb 27 doi: 10.1016/j.coi.2015.02.005. PMID: 25728991Free PMC Article
Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M
J Immunol 2015 Feb 1;194(3):911-20. Epub 2014 Dec 17 doi: 10.4049/jimmunol.1402346. PMID: 25520398
Tietze JK, Wilkins DE, Sckisel GD, Bouchlaka MN, Alderson KL, Weiss JM, Ames E, Bruhn KW, Craft N, Wiltrout RH, Longo DL, Lanier LL, Blazar BR, Redelman D, Murphy WJ
Blood 2012 Mar 29;119(13):3073-83. Epub 2012 Jan 17 doi: 10.1182/blood-2011-07-369736. PMID: 22251483Free PMC Article

Prognosis

von Delft A, Humphreys IS, Brown A, Pfafferott K, Lucas M, Klenerman P, Lauer GM, Cox AL, Gaudieri S, Barnes E
Gut 2016 Jan;65(1):112-23. Epub 2015 Jun 19 doi: 10.1136/gutjnl-2014-308724. PMID: 26092843Free PMC Article
van den Berg JH, Gomez-Eerland R, van de Wiel B, Hulshoff L, van den Broek D, Bins A, Tan HL, Harper JV, Hassan NJ, Jakobsen BK, Jorritsma A, Blank CU, Schumacher TN, Haanen JB
Mol Ther 2015 Sep;23(9):1541-50. Epub 2015 Apr 21 doi: 10.1038/mt.2015.60. PMID: 25896248Free PMC Article
Geyeregger R, Freimüller C, Stemberger J, Artwohl M, Witt V, Lion T, Fischer G, Lawitschka A, Ritter J, Hummel M, Holter W, Fritsch G, Matthes-Martin S
J Immunother 2014 May;37(4):245-9. doi: 10.1097/CJI.0000000000000034. PMID: 24714358
Ayasoufi K, Yu H, Fan R, Wang X, Williams J, Valujskikh A
Am J Transplant 2013 Mar;13(3):589-99. Epub 2013 Jan 17 doi: 10.1111/ajt.12068. PMID: 23331999Free PMC Article
Gómez-Díaz RA, Aguilar MV, Meguro EN, Márquez RH, Magaña EG, Martinez-García MC, Rodarte NW, Aguilar-Salinas CA, Canché-Pool E, Ortiz-Navarrete V
Curr Diabetes Rev 2011 Jul;7(4):278-83. PMID: 21644914

Clinical prediction guides

Qian C, Wang Y, Cai H, Laroye C, De Carvalho Bittencourt M, Clement L, Stoltz JF, Decot V, Reppel L, Bensoussan D
J Immunother 2016 Jan;39(1):27-35. doi: 10.1097/CJI.0000000000000105. PMID: 26641259
von Delft A, Humphreys IS, Brown A, Pfafferott K, Lucas M, Klenerman P, Lauer GM, Cox AL, Gaudieri S, Barnes E
Gut 2016 Jan;65(1):112-23. Epub 2015 Jun 19 doi: 10.1136/gutjnl-2014-308724. PMID: 26092843Free PMC Article
van den Berg JH, Gomez-Eerland R, van de Wiel B, Hulshoff L, van den Broek D, Bins A, Tan HL, Harper JV, Hassan NJ, Jakobsen BK, Jorritsma A, Blank CU, Schumacher TN, Haanen JB
Mol Ther 2015 Sep;23(9):1541-50. Epub 2015 Apr 21 doi: 10.1038/mt.2015.60. PMID: 25896248Free PMC Article
Kobayashi Y, Ito Y, Ostapenko VV, Sakai M, Matsushita N, Imai K, Shimizu K, Aruga A, Tanigawa K
Immunol Lett 2014 Nov;162(1 Pt A):256-61. Epub 2014 Sep 26 doi: 10.1016/j.imlet.2014.09.014. PMID: 25256774
Plesa G, Zheng L, Medvec A, Wilson CB, Robles-Oteiza C, Liddy N, Bennett AD, Gavarret J, Vuidepot A, Zhao Y, Blazar BR, Jakobsen BK, Riley JL
Blood 2012 Apr 12;119(15):3420-30. Epub 2012 Feb 7 doi: 10.1182/blood-2011-09-377051. PMID: 22318202Free PMC Article

Recent systematic reviews

Almåsbak H, Aarvak T, Vemuri MC
J Immunol Res 2016;2016:5474602. Epub 2016 May 19 doi: 10.1155/2016/5474602. PMID: 27298832Free PMC Article
Krishnamurthy B, Selck C, Chee J, Jhala G, Kay TW
J Autoimmun 2016 Jul;71:35-43. Epub 2016 Apr 12 doi: 10.1016/j.jaut.2016.03.018. PMID: 27083395
Lévy F, Colombetti S
Int Rev Immunol 2006 Sep-Dec;25(5-6):269-95. doi: 10.1080/08830180600992407. PMID: 17169777

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