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Items: 1 to 20 of 27

1.

Anoxia of brain

MedGen UID:
242383
Concept ID:
C0995195
Pathologic Function
2.

Erythropoietin

Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation. [from MeSH]

MedGen UID:
41863
Concept ID:
C0014822
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
3.

General anesthetic

Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173) [from MeSH]

MedGen UID:
4861
Concept ID:
C0017302
Pharmacologic Substance
4.

Anesthetic

A pharmacological agent that acts in a reversible fashion and can be applied either locally or systemically to cause a partial or total loss of sensation and pain or to induce unconsciousness. [from NCI]

MedGen UID:
1535
Concept ID:
C0002932
Pharmacologic Substance
5.

Hypoxia

A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). [from NCI]

MedGen UID:
66846
Concept ID:
C0242184
Pathologic Function
6.

Oxygen

An element with atomic symbol O, atomic number 8, and atomic weight 16. [from NCI]

MedGen UID:
45267
Concept ID:
C0030054
Biologically Active Substance; Element, Ion, or Isotope; Pharmacologic Substance
7.

Halothane

A nonflammable, halogenated, hydrocarbon and general inhalation anesthetic. Although the exact mechanism of action is unknown, halothane provides relatively rapid induction of anesthesia by depressing the central nervous system, thereby producing a reversible loss of consciousness and sensation. (NCI05) [from NCI]

MedGen UID:
42328
Concept ID:
C0018549
Organic Chemical; Pharmacologic Substance
8.

Sevoflurane

A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate. [from NCI]

MedGen UID:
22936
Concept ID:
C0074414
Organic Chemical; Pharmacologic Substance
9.

Propofol

A hypnotic alkylphenol derivative. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA). This agent is associated with minimal respiratory depression and has a short half-life with a duration of action of 2 to 10 minutes. [from NCI]

MedGen UID:
18683
Concept ID:
C0033487
Organic Chemical; Pharmacologic Substance
10.

Pentobarbital

A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236) [from MeSH]

MedGen UID:
18362
Concept ID:
C0030883
Organic Chemical; Pharmacologic Substance
11.

Nitrous oxide

A naturally occurring gas that is colorless and non flammable. It can be manufactured and used for a variety of things such as a pharmacologic agent to produce anesthesia, a food additive as a propellant, and an additive to fuels to increase available oxygen in combustion. [from NCI]

MedGen UID:
18062
Concept ID:
C0028215
Biologically Active Substance; Inorganic Chemical; Pharmacologic Substance
12.

Ketamine

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors. [from MeSH]

MedGen UID:
9629
Concept ID:
C0022614
Organic Chemical; Pharmacologic Substance
13.

Isoflurane

A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake, and potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery. [from NCI]

MedGen UID:
5908
Concept ID:
C0022180
Organic Chemical; Pharmacologic Substance
14.

Central

Applies to an abnormality that is located close to the median plane or midline of the body or of the referenced structure. [from HPO]

MedGen UID:
59958
Concept ID:
C0205099
Spatial Concept
15.

Hypoxemia

MedGen UID:
152145
Concept ID:
C0700292
Finding
16.

Respiratory symptom

Respiratory system manifestations of diseases of the respiratory tract or of other organs. [from MeSH]

MedGen UID:
20754
Concept ID:
C0037090
Sign or Symptom
17.

Clinical finding

Clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient. [from MeSH]

MedGen UID:
19974
Concept ID:
C0037088
Sign or Symptom
18.

UPREG

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
12003
Concept ID:
C0041904
Molecular Function
19.

CNS DEPRESS

A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents). [from MeSH]

MedGen UID:
3305
Concept ID:
C0007681
Pharmacologic Substance
20.

Oxygen supply absent

Absence or reduction of oxygen in body tissue. [from NCI]

MedGen UID:
1953
Concept ID:
C0003130
Pathologic Function
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