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Mesothelioma, malignant(MESOM)

MedGen UID:
91062
Concept ID:
C0345967
Neoplastic Process
Synonyms: MESOM
Modes of inheritance:
Somatic mutation
MedGen UID:
107465
Concept ID:
C0544886
Cell or Molecular Dysfunction
Sources: HPO, OMIM
A mode of inheritance in which a trait or disorder results from a de novo mutation occurring after conception, rather than being inherited from a preceding generation.
Somatic mutation (HPO, OMIM)
SNOMED CT: Mesothelioma, malignant (62064005); Malignant mesothelioma (62064005); Mesothelioma (malignant, clinical disorder) (109378008); Malignant mesothelioma (109378008); Cancer, mesothelioma (109378008)
 
Genes (locations): BCL10 (1p22.3); WT1 (11p13)
OMIM®: 156240
HPO: HP:0100001

Definition

Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21. [from OMIM]

Clinical features

Mesothelioma, malignant
MedGen UID:
91062
Concept ID:
C0345967
Neoplastic Process
Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesothelioma, malignant

Conditions with this feature

Mesothelioma, malignant
MedGen UID:
91062
Concept ID:
C0345967
Neoplastic Process
Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21.

Recent clinical studies

Etiology

Elliott HS, Metser U, de Perrot M, Cho J, Bradbury P, Veit-Haibach P, Hussey D, Noam T
Br J Radiol 2018 Jun;91(1086):20170814. Epub 2018 Mar 29 doi: 10.1259/bjr.20170814. PMID: 29498536
Fisher SB, Rafeeq S, Hess K, Grotz TE, Mansfield P, Royal R, Badgwell B, Fleming J, Fournier K, Mann GN
J Surg Oncol 2018 Mar;117(4):685-691. Epub 2017 Nov 28 doi: 10.1002/jso.24904. PMID: 29193085
Nguyen BH, Montgomery R, Fadia M, Wang J, Ali S
Asia Pac J Clin Oncol 2018 Feb;14(1):69-73. Epub 2017 Nov 3 doi: 10.1111/ajco.12788. PMID: 29105302
Jiang Z, Chen T, Chen J, Ying S, Gao Z, He X, Miao C, Yu M, Feng L, Xia H, Wu W, Chen R, Morinaga K, Lou J, Zhang X
Int J Cancer 2018 Feb 1;142(3):514-523. Epub 2017 Oct 10 doi: 10.1002/ijc.31077. PMID: 28949000
Habougit C, Trombert-Paviot B, Karpathiou G, Casteillo F, Bayle-Bleuez S, Fournel P, Vergnon JM, Tiffet O, Péoc'h M, Forest F
Virchows Arch 2017 Jun;470(6):639-646. Epub 2017 Mar 27 doi: 10.1007/s00428-017-2109-z. PMID: 28349237

Diagnosis

Chen F, Liu B, Yu Y, Du J, Chen D
World Neurosurg 2018 Jun;114:211-216. Epub 2018 Mar 26 doi: 10.1016/j.wneu.2018.03.124. PMID: 29588242
Hattori Y, Sentani K, Hattori T, Oue N, Yasui W
APMIS 2018 Feb;126(2):166-170. Epub 2017 Dec 13 doi: 10.1111/apm.12789. PMID: 29235141
Fisher SB, Rafeeq S, Hess K, Grotz TE, Mansfield P, Royal R, Badgwell B, Fleming J, Fournier K, Mann GN
J Surg Oncol 2018 Mar;117(4):685-691. Epub 2017 Nov 28 doi: 10.1002/jso.24904. PMID: 29193085
Davidson B, Pinamonti M, Cuevas D, Holth A, Zeppa P, Hager T, Wohlschlaeger J, Tötsch M
Virchows Arch 2018 Mar;472(3):425-432. Epub 2017 Nov 24 doi: 10.1007/s00428-017-2273-1. PMID: 29170871
Habougit C, Trombert-Paviot B, Karpathiou G, Casteillo F, Bayle-Bleuez S, Fournel P, Vergnon JM, Tiffet O, Péoc'h M, Forest F
Virchows Arch 2017 Jun;470(6):639-646. Epub 2017 Mar 27 doi: 10.1007/s00428-017-2109-z. PMID: 28349237

Therapy

Abdel-Rahman O, Elsayed Z, Mohamed H, Eltobgy M
Cochrane Database Syst Rev 2018 Jan 8;1:CD012605. doi: 10.1002/14651858.CD012605.pub2. PMID: 29309720
Fisher SB, Rafeeq S, Hess K, Grotz TE, Mansfield P, Royal R, Badgwell B, Fleming J, Fournier K, Mann GN
J Surg Oncol 2018 Mar;117(4):685-691. Epub 2017 Nov 28 doi: 10.1002/jso.24904. PMID: 29193085
Jiang Z, Chen T, Chen J, Ying S, Gao Z, He X, Miao C, Yu M, Feng L, Xia H, Wu W, Chen R, Morinaga K, Lou J, Zhang X
Int J Cancer 2018 Feb 1;142(3):514-523. Epub 2017 Oct 10 doi: 10.1002/ijc.31077. PMID: 28949000
Reid A, Merler E, Peters S, Jayasinghe N, Bressan V, Franklin P, Brims F, de Klerk NH, Musk AW
Occup Environ Med 2018 Jan;75(1):29-36. Epub 2017 Jul 29 doi: 10.1136/oemed-2017-104322. PMID: 28756413
Jhavar S, Pruszynski J, Gowan A, Boyle T, Deb N, Patel M
Asia Pac J Clin Oncol 2018 Apr;14(2):e88-e94. Epub 2017 Mar 29 doi: 10.1111/ajco.12680. PMID: 28371288

Prognosis

Chen F, Liu B, Yu Y, Du J, Chen D
World Neurosurg 2018 Jun;114:211-216. Epub 2018 Mar 26 doi: 10.1016/j.wneu.2018.03.124. PMID: 29588242
Fisher SB, Rafeeq S, Hess K, Grotz TE, Mansfield P, Royal R, Badgwell B, Fleming J, Fournier K, Mann GN
J Surg Oncol 2018 Mar;117(4):685-691. Epub 2017 Nov 28 doi: 10.1002/jso.24904. PMID: 29193085
Nguyen BH, Montgomery R, Fadia M, Wang J, Ali S
Asia Pac J Clin Oncol 2018 Feb;14(1):69-73. Epub 2017 Nov 3 doi: 10.1111/ajco.12788. PMID: 29105302
Kapeles M, Gensheimer MF, Mart DA, Sottero TL, Kusano AS, Truong A, Farjah F, Laramore GE, Stelzer KJ, Patel SA
Am J Clin Oncol 2018 Jan;41(1):30-35. doi: 10.1097/COC.0000000000000225. PMID: 26353120
Habougit C, Trombert-Paviot B, Karpathiou G, Casteillo F, Bayle-Bleuez S, Fournel P, Vergnon JM, Tiffet O, Péoc'h M, Forest F
Virchows Arch 2017 Jun;470(6):639-646. Epub 2017 Mar 27 doi: 10.1007/s00428-017-2109-z. PMID: 28349237

Clinical prediction guides

Abdel-Rahman O, Elsayed Z, Mohamed H, Eltobgy M
Cochrane Database Syst Rev 2018 Jan 8;1:CD012605. doi: 10.1002/14651858.CD012605.pub2. PMID: 29309720
Fisher SB, Rafeeq S, Hess K, Grotz TE, Mansfield P, Royal R, Badgwell B, Fleming J, Fournier K, Mann GN
J Surg Oncol 2018 Mar;117(4):685-691. Epub 2017 Nov 28 doi: 10.1002/jso.24904. PMID: 29193085
Jhavar S, Pruszynski J, Gowan A, Boyle T, Deb N, Patel M
Asia Pac J Clin Oncol 2018 Apr;14(2):e88-e94. Epub 2017 Mar 29 doi: 10.1111/ajco.12680. PMID: 28371288
Habougit C, Trombert-Paviot B, Karpathiou G, Casteillo F, Bayle-Bleuez S, Fournel P, Vergnon JM, Tiffet O, Péoc'h M, Forest F
Virchows Arch 2017 Jun;470(6):639-646. Epub 2017 Mar 27 doi: 10.1007/s00428-017-2109-z. PMID: 28349237
Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
J Korean Med Sci 2014 Nov;29(11):1464-72. Epub 2014 Nov 4 doi: 10.3346/jkms.2014.29.11.1464. PMID: 25408576Free PMC Article

Recent systematic reviews

Chen F, Liu B, Yu Y, Du J, Chen D
World Neurosurg 2018 Jun;114:211-216. Epub 2018 Mar 26 doi: 10.1016/j.wneu.2018.03.124. PMID: 29588242
Abdel-Rahman O, Elsayed Z, Mohamed H, Eltobgy M
Cochrane Database Syst Rev 2018 Jan 8;1:CD012605. doi: 10.1002/14651858.CD012605.pub2. PMID: 29309720
Marsh GM PhD Face, Riordan AS Mph, Keeton KA Mph, Benson SM PhD
Occup Environ Med 2017 Nov;74(11):838-846. Epub 2017 Sep 21 doi: 10.1136/oemed-2017-104383. PMID: 28935666
Ashton M, O'Rourke N, Currie S, Rimner A, Chalmers A
Radiother Oncol 2017 Oct;125(1):1-12. Epub 2017 Aug 28 doi: 10.1016/j.radonc.2017.08.003. PMID: 28859932Free PMC Article
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639

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