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Depression

MedGen UID:
137999
Concept ID:
C0344315
Finding
Synonyms: Decreased Mood; Depressed; Depressed mood; Depressed Mood; Low Mood
SNOMED CT: Depressed (35489007); Depressed mood (366979004)
 

Definition

Depression (also known as major depression or major depressive disorder) is a psychiatric disorder that affects mood, behavior, and overall health. It causes prolonged feelings of sadness, emptiness, or hopelessness, and a loss of interest in activities that were once enjoyed. People with depression may also have changes in appetite (leading to overeating or not eating enough), changes in sleeping patterns (sleeping too much or not being able to sleep), loss of energy, and difficulty concentrating. Although depression is considered primarily a mental health disorder, it can also have physical features including headaches, other unexplained aches and pains, unusually slow or fast movements, and digestive problems. To be diagnosed with depression, an individual must have signs and symptoms nearly every day for at least 2 weeks. However, the features of this condition vary widely.Depression most commonly begins in late adolescence or early adulthood, although it can appear at any age. If untreated, episodes of depression can last for weeks, months, or years, and can go away and come back (recur). Affected individuals may have difficulty functioning in their daily lives, including at school or work. People with depression have a higher risk of substance abuse problems and dying by suicide than the general population.Several health conditions are closely related to depression or have depression as a characteristic feature. These include dysthymia (which has long-lasting signs and symptoms that are similar to, but not as severe as, those of depression), perinatal or postpartum depression (which occurs around or following the birth of a child), seasonal affective disorder (which is triggered by the changing of the seasons), bipolar disorder (which can include both "highs," or manic episodes, and depressive episodes), and generalized anxiety disorder. In people with schizoaffective disorder, depression or another mood disorder occurs together with features of schizophrenia (a brain disorder that affects a person's thinking, sense of self, and perceptions).
[from GHR]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDepression

Recent clinical studies

Etiology

Kamat N, Rajan Mallayasamy S, Sharma PSVN, Kamath A, Pai CG
Postgrad Med 2018 Apr;130(3):355-360. Epub 2018 Feb 23 doi: 10.1080/00325481.2018.1442978. PMID: 29460659
Wassertheil-Smoller S, Qi Q, Dave T, Mitchell BD, Jackson RD, Liu S, Park K, Salinas J, Dunn EC, Leira EC, Xu H, Ryan K, Smoller JW
Stroke 2018 Mar;49(3):543-548. Epub 2018 Feb 8 doi: 10.1161/STROKEAHA.117.018857. PMID: 29438084Free PMC Article
Shreders AJ, Niazi SK, Hodge DO, Chimato NT, Kureti M, Kirla N, Agrawal A, Swaika A, Gustetic E, Foster R, Nelson KA, Jani P, Chanan-Khan AA, Ailawadhi S
Ann Hematol 2018 Mar;97(3):519-528. Epub 2017 Dec 7 doi: 10.1007/s00277-017-3198-0. PMID: 29218388
Nyberg A, Magnusson Hanson LL, Leineweber C, Hammarström A, Theorell T
Scand J Public Health 2018 May;46(3):425-432. Epub 2017 Dec 5 doi: 10.1177/1403494817745736. PMID: 29207928
Pfeil S, Holtz K, Kopf KA, Hegerl U, Rummel-Kluge C
BMC Psychiatry 2017 Jul 5;17(1):243. doi: 10.1186/s12888-017-1404-1. PMID: 28679439Free PMC Article

Diagnosis

Shreders AJ, Niazi SK, Hodge DO, Chimato NT, Kureti M, Kirla N, Agrawal A, Swaika A, Gustetic E, Foster R, Nelson KA, Jani P, Chanan-Khan AA, Ailawadhi S
Ann Hematol 2018 Mar;97(3):519-528. Epub 2017 Dec 7 doi: 10.1007/s00277-017-3198-0. PMID: 29218388
Strober B, Gooderham M, de Jong EMGJ, Kimball AB, Langley RG, Lakdawala N, Goyal K, Lawson F, Langholff W, Hopkins L, Fakharzadeh S, Srivastava B, Menter A
J Am Acad Dermatol 2018 Jan;78(1):70-80. Epub 2017 Nov 6 doi: 10.1016/j.jaad.2017.08.051. PMID: 29102053
Harvey SB, Øverland S, Hatch SL, Wessely S, Mykletun A, Hotopf M
Am J Psychiatry 2018 Jan 1;175(1):28-36. Epub 2017 Oct 3 doi: 10.1176/appi.ajp.2017.16111223. PMID: 28969440
El-Den S, Chen TF, Gan YL, Wong E, O'Reilly CL
J Affect Disord 2018 Jan 1;225:503-522. Epub 2017 Aug 23 doi: 10.1016/j.jad.2017.08.060. PMID: 28866295
Pfeil S, Holtz K, Kopf KA, Hegerl U, Rummel-Kluge C
BMC Psychiatry 2017 Jul 5;17(1):243. doi: 10.1186/s12888-017-1404-1. PMID: 28679439Free PMC Article

Therapy

Sun Y, Xu X, Zhang J, Chen Y
BMC Complement Altern Med 2018 Feb 17;18(1):66. doi: 10.1186/s12906-018-2130-z. PMID: 29454341Free PMC Article
Strober B, Gooderham M, de Jong EMGJ, Kimball AB, Langley RG, Lakdawala N, Goyal K, Lawson F, Langholff W, Hopkins L, Fakharzadeh S, Srivastava B, Menter A
J Am Acad Dermatol 2018 Jan;78(1):70-80. Epub 2017 Nov 6 doi: 10.1016/j.jaad.2017.08.051. PMID: 29102053
Mulvahill JS, Nicol GE, Dixon D, Lenze EJ, Karp JF, Reynolds CF 3rd, Blumberger DM, Mulsant BH
J Am Geriatr Soc 2017 Dec;65(12):2651-2658. doi: 10.1111/jgs.15129. PMID: 29235659Free PMC Article
Lesko CR, Todd JV, Cole SR, Edmonds A, Pence BW, Edwards JK, Mack WJ, Bacchetti P, Rubtsova A, Gange SJ, Adimora AA; WIHS Investigators.
Ann Epidemiol 2017 Dec;27(12):783-789.e2. Epub 2017 Sep 5 doi: 10.1016/j.annepidem.2017.08.021. PMID: 28939001Free PMC Article
Newby JM, Mewton L, Andrews G
J Anxiety Disord 2017 Mar;46:25-34. Epub 2016 Jun 23 doi: 10.1016/j.janxdis.2016.06.002. PMID: 27396841

Prognosis

Strober B, Gooderham M, de Jong EMGJ, Kimball AB, Langley RG, Lakdawala N, Goyal K, Lawson F, Langholff W, Hopkins L, Fakharzadeh S, Srivastava B, Menter A
J Am Acad Dermatol 2018 Jan;78(1):70-80. Epub 2017 Nov 6 doi: 10.1016/j.jaad.2017.08.051. PMID: 29102053
Mulvahill JS, Nicol GE, Dixon D, Lenze EJ, Karp JF, Reynolds CF 3rd, Blumberger DM, Mulsant BH
J Am Geriatr Soc 2017 Dec;65(12):2651-2658. doi: 10.1111/jgs.15129. PMID: 29235659Free PMC Article
Altino DM, Nogueira-Martins LA, de Barros ALBL, Lopes JL
Arch Psychiatr Nurs 2017 Dec;31(6):549-552. Epub 2017 Jul 21 doi: 10.1016/j.apnu.2017.07.004. PMID: 29179819
Lesko CR, Todd JV, Cole SR, Edmonds A, Pence BW, Edwards JK, Mack WJ, Bacchetti P, Rubtsova A, Gange SJ, Adimora AA; WIHS Investigators.
Ann Epidemiol 2017 Dec;27(12):783-789.e2. Epub 2017 Sep 5 doi: 10.1016/j.annepidem.2017.08.021. PMID: 28939001Free PMC Article
Smagula SF, Krafty RT, Taylor BJ, Martire LM, Schulz R, Hall MH
J Sleep Res 2017 Dec;26(6):718-725. Epub 2017 May 10 doi: 10.1111/jsr.12549. PMID: 28488270Free PMC Article

Clinical prediction guides

Kamat N, Rajan Mallayasamy S, Sharma PSVN, Kamath A, Pai CG
Postgrad Med 2018 Apr;130(3):355-360. Epub 2018 Feb 23 doi: 10.1080/00325481.2018.1442978. PMID: 29460659
Wassertheil-Smoller S, Qi Q, Dave T, Mitchell BD, Jackson RD, Liu S, Park K, Salinas J, Dunn EC, Leira EC, Xu H, Ryan K, Smoller JW
Stroke 2018 Mar;49(3):543-548. Epub 2018 Feb 8 doi: 10.1161/STROKEAHA.117.018857. PMID: 29438084Free PMC Article
Shreders AJ, Niazi SK, Hodge DO, Chimato NT, Kureti M, Kirla N, Agrawal A, Swaika A, Gustetic E, Foster R, Nelson KA, Jani P, Chanan-Khan AA, Ailawadhi S
Ann Hematol 2018 Mar;97(3):519-528. Epub 2017 Dec 7 doi: 10.1007/s00277-017-3198-0. PMID: 29218388
Strober B, Gooderham M, de Jong EMGJ, Kimball AB, Langley RG, Lakdawala N, Goyal K, Lawson F, Langholff W, Hopkins L, Fakharzadeh S, Srivastava B, Menter A
J Am Acad Dermatol 2018 Jan;78(1):70-80. Epub 2017 Nov 6 doi: 10.1016/j.jaad.2017.08.051. PMID: 29102053
Newby JM, Mewton L, Andrews G
J Anxiety Disord 2017 Mar;46:25-34. Epub 2016 Jun 23 doi: 10.1016/j.janxdis.2016.06.002. PMID: 27396841

Recent systematic reviews

Sun Y, Xu X, Zhang J, Chen Y
BMC Complement Altern Med 2018 Feb 17;18(1):66. doi: 10.1186/s12906-018-2130-z. PMID: 29454341Free PMC Article
Tung YJ, Lo KKH, Ho RCM, Tam WSW
Nurse Educ Today 2018 Apr;63:119-129. Epub 2018 Feb 9 doi: 10.1016/j.nedt.2018.01.009. PMID: 29432998
Paganini S, Teigelkötter W, Buntrock C, Baumeister H
J Affect Disord 2018 Jan 1;225:733-755. Epub 2017 Jul 18 doi: 10.1016/j.jad.2017.07.018. PMID: 28922737
El-Den S, Chen TF, Gan YL, Wong E, O'Reilly CL
J Affect Disord 2018 Jan 1;225:503-522. Epub 2017 Aug 23 doi: 10.1016/j.jad.2017.08.060. PMID: 28866295
Fialho R, Pereira M, Rusted J, Whale R
Psychol Health Med 2017 Oct;22(9):1089-1104. Epub 2017 Jan 19 doi: 10.1080/13548506.2017.1280177. PMID: 28100073

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