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Docetaxel

MedGen UID:
70063
Concept ID:
C0246415
Organic Chemical; Pharmacologic Substance
Synonyms: Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester; docetaxel; docetaxel hydrate; docetaxel trihydrate; docetaxol
SNOMED CT: Docetaxel (386918005); Docetaxel (108806006)
 

Definition

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04) [from NCI]

Recent clinical studies

Etiology

Tagawa N, Sugiyama E, Tajima M, Sasaki Y, Nakamura S, Okuyama H, Shimizu H, Sato VH, Sasaki T, Sato H
Cancer Chemother Pharmacol 2017 Oct;80(4):841-849. Epub 2017 Sep 1 doi: 10.1007/s00280-017-3425-3. PMID: 28864856
Kim J, Lee YJ, Kim YA, Cho ES, Huh E, Bang OS, Kim NS
BMC Complement Altern Med 2017 Aug 9;17(1):393. doi: 10.1186/s12906-017-1890-1. PMID: 28793897Free PMC Article
Bergin ART, Hovey E, Lloyd A, Marx G, Parente P, Rapke T, de Souza P
Support Care Cancer 2017 Sep;25(9):2871-2879. Epub 2017 Apr 20 doi: 10.1007/s00520-017-3706-8. PMID: 28429147
Bianchini G, Kiermaier A, Bianchi GV, Im YH, Pienkowski T, Liu MC, Tseng LM, Dowsett M, Zabaglo L, Kirk S, Szado T, Eng-Wong J, Amler LC, Valagussa P, Gianni L
Breast Cancer Res 2017 Feb 9;19(1):16. doi: 10.1186/s13058-017-0806-9. PMID: 28183321Free PMC Article
Faqeer NA, Mashni O, Dawoud R, Rumman A, Hanoun E, Nazer L
J Clin Pharmacol 2017 Feb;57(2):275-279. Epub 2016 Aug 23 doi: 10.1002/jcph.803. PMID: 27479828

Diagnosis

Bianchini G, Kiermaier A, Bianchi GV, Im YH, Pienkowski T, Liu MC, Tseng LM, Dowsett M, Zabaglo L, Kirk S, Szado T, Eng-Wong J, Amler LC, Valagussa P, Gianni L
Breast Cancer Res 2017 Feb 9;19(1):16. doi: 10.1186/s13058-017-0806-9. PMID: 28183321Free PMC Article
Huang M, Lou Y, Pellissier J, Burke T, Liu FX, Xu R, Velcheti V
J Med Econ 2017 Feb;20(2):140-150. Epub 2016 Oct 3 doi: 10.1080/13696998.2016.1230123. PMID: 27571538
Faqeer NA, Mashni O, Dawoud R, Rumman A, Hanoun E, Nazer L
J Clin Pharmacol 2017 Feb;57(2):275-279. Epub 2016 Aug 23 doi: 10.1002/jcph.803. PMID: 27479828
Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L
Mol Cancer 2016 Nov 10;15(1):70. doi: 10.1186/s12943-016-0556-9. PMID: 27832783Free PMC Article
Wang TY, Chen WM, Yang LY, Chen CY, Chou WC, Chen YY, Chen CC, Lee KD, Lu CH
Support Care Cancer 2016 Nov;24(11):4697-703. Epub 2016 Jun 21 doi: 10.1007/s00520-016-3318-8. PMID: 27329415

Therapy

Tagawa N, Sugiyama E, Tajima M, Sasaki Y, Nakamura S, Okuyama H, Shimizu H, Sato VH, Sasaki T, Sato H
Cancer Chemother Pharmacol 2017 Oct;80(4):841-849. Epub 2017 Sep 1 doi: 10.1007/s00280-017-3425-3. PMID: 28864856
Kim J, Lee YJ, Kim YA, Cho ES, Huh E, Bang OS, Kim NS
BMC Complement Altern Med 2017 Aug 9;17(1):393. doi: 10.1186/s12906-017-1890-1. PMID: 28793897Free PMC Article
Armstrong CM, Liu C, Lou W, Lombard AP, Evans CP, Gao AC
Prostate 2017 Jun;77(9):1020-1028. doi: 10.1002/pros.23358. PMID: 28485104Free PMC Article
Bergin ART, Hovey E, Lloyd A, Marx G, Parente P, Rapke T, de Souza P
Support Care Cancer 2017 Sep;25(9):2871-2879. Epub 2017 Apr 20 doi: 10.1007/s00520-017-3706-8. PMID: 28429147
Grudén S, Sandelin M, Rasanen V, Micke P, Hedeland M, Axén N, Jeansson M
Eur J Pharm Biopharm 2017 May;114:186-193. Epub 2017 Feb 1 doi: 10.1016/j.ejpb.2017.01.018. PMID: 28161551

Prognosis

Horn L, Spigel DR, Vokes EE, Holgado E, Ready N, Steins M, Poddubskaya E, Borghaei H, Felip E, Paz-Ares L, Pluzanski A, Reckamp KL, Burgio MA, Kohlhäeufl M, Waterhouse D, Barlesi F, Antonia S, Arrieta O, Fayette J, Crinò L, Rizvi N, Reck M, Hellmann MD, Geese WJ, Li A, Blackwood-Chirchir A, Healey D, Brahmer J, Eberhardt WEE
J Clin Oncol 2017 Dec 10;35(35):3924-3933. Epub 2017 Oct 12 doi: 10.1200/JCO.2017.74.3062. PMID: 29023213
Tagawa N, Sugiyama E, Tajima M, Sasaki Y, Nakamura S, Okuyama H, Shimizu H, Sato VH, Sasaki T, Sato H
Cancer Chemother Pharmacol 2017 Oct;80(4):841-849. Epub 2017 Sep 1 doi: 10.1007/s00280-017-3425-3. PMID: 28864856
Kim J, Lee YJ, Kim YA, Cho ES, Huh E, Bang OS, Kim NS
BMC Complement Altern Med 2017 Aug 9;17(1):393. doi: 10.1186/s12906-017-1890-1. PMID: 28793897Free PMC Article
Faqeer NA, Mashni O, Dawoud R, Rumman A, Hanoun E, Nazer L
J Clin Pharmacol 2017 Feb;57(2):275-279. Epub 2016 Aug 23 doi: 10.1002/jcph.803. PMID: 27479828
Wang Y, Lieberman R, Pan J, Zhang Q, Du M, Zhang P, Nevalainen M, Kohli M, Shenoy NK, Meng H, You M, Wang L
Mol Cancer 2016 Nov 10;15(1):70. doi: 10.1186/s12943-016-0556-9. PMID: 27832783Free PMC Article

Clinical prediction guides

Tagawa N, Sugiyama E, Tajima M, Sasaki Y, Nakamura S, Okuyama H, Shimizu H, Sato VH, Sasaki T, Sato H
Cancer Chemother Pharmacol 2017 Oct;80(4):841-849. Epub 2017 Sep 1 doi: 10.1007/s00280-017-3425-3. PMID: 28864856
Kim J, Lee YJ, Kim YA, Cho ES, Huh E, Bang OS, Kim NS
BMC Complement Altern Med 2017 Aug 9;17(1):393. doi: 10.1186/s12906-017-1890-1. PMID: 28793897Free PMC Article
Armstrong CM, Liu C, Lou W, Lombard AP, Evans CP, Gao AC
Prostate 2017 Jun;77(9):1020-1028. doi: 10.1002/pros.23358. PMID: 28485104Free PMC Article
Bergin ART, Hovey E, Lloyd A, Marx G, Parente P, Rapke T, de Souza P
Support Care Cancer 2017 Sep;25(9):2871-2879. Epub 2017 Apr 20 doi: 10.1007/s00520-017-3706-8. PMID: 28429147
Bianchini G, Kiermaier A, Bianchi GV, Im YH, Pienkowski T, Liu MC, Tseng LM, Dowsett M, Zabaglo L, Kirk S, Szado T, Eng-Wong J, Amler LC, Valagussa P, Gianni L
Breast Cancer Res 2017 Feb 9;19(1):16. doi: 10.1186/s13058-017-0806-9. PMID: 28183321Free PMC Article

Recent systematic reviews

Tian T, Ye J, Zhou S
Int J Clin Pharmacol Ther 2017 Sep;55(9):720-727. doi: 10.5414/CP202921. PMID: 28737130
Bergin ART, Hovey E, Lloyd A, Marx G, Parente P, Rapke T, de Souza P
Support Care Cancer 2017 Sep;25(9):2871-2879. Epub 2017 Apr 20 doi: 10.1007/s00520-017-3706-8. PMID: 28429147
Petrioli R, Roviello G, Zanotti L, Roviello F, Polom K, Bottini A, Marano L, Francini E, Marrelli D, Generali D
Crit Rev Oncol Hematol 2016 Jun;102:82-8. Epub 2016 Apr 8 doi: 10.1016/j.critrevonc.2016.04.001. PMID: 27083592
Tucci M, Bertaglia V, Vignani F, Buttigliero C, Fiori C, Porpiglia F, Scagliotti GV, Di Maio M
Eur Urol 2016 Apr;69(4):563-73. Epub 2015 Sep 28 doi: 10.1016/j.eururo.2015.09.013. PMID: 26422676
Hugenholtz-Wamsteker W, Robbeson C, Nijs J, Hoelen W, Meeus M
Eur J Cancer Care (Engl) 2016 Mar;25(2):269-79. Epub 2014 Oct 27 doi: 10.1111/ecc.12261. PMID: 25348689

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