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Items: 1 to 20 of 36

1.

Related

MedGen UID:
619805
Concept ID:
C0445223
Finding
2.

DNA Methylation

The process by which methyl groups are added to nucleotides in genomic DNA. [from NCI]

MedGen UID:
138191
Concept ID:
C0376452
Molecular Function
3.

Folate

A cofactor for 1-carbon transfer involved with DNA synthesis. [from NCI]

MedGen UID:
59819
Concept ID:
C0178638
Organic Chemical; Pharmacologic Substance; Vitamin
4.

Methylation

The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI) [from NCI]

MedGen UID:
44400
Concept ID:
C0025723
Molecular Function
5.

Resveratrol

A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. (NCI05) [from NCI]

MedGen UID:
35162
Concept ID:
C0073096
Organic Chemical; Pharmacologic Substance
6.

Polyphenol

A large class of organic compounds having more than one PHENOL group. [from MeSH]

MedGen UID:
34867
Concept ID:
C0071649
Organic Chemical; Pharmacologic Substance
7.

Ademetionine

A nutritional supplement that is synthesized from adenosine triphosphate (ATP) and the amino acid methionine by the endogenous essential enzyme methionine adenosyltransferase (MAT), with potential antineoplastic activity. Upon administration, S-adenosylmethionine acts as a methyl donor for various transmethylation reactions. In cancer cells, this agent induces the methylation of tumor promoting genes, reverses DNA hypomethylation, and leads to the suppression of oncogene transcription. This induces apoptosis in and inhibits proliferation of susceptible tumor cells. [from NCI]

MedGen UID:
19852
Concept ID:
C0036002
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
8.

Riboflavin

An essential human nutrient that is a heat-stable and water-soluble flavin belonging to the vitamin B family. Riboflavin is a precursor of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are of vital importance in normal tissue respiration, pyridoxine activation, tryptophan to niacin conversion, fat, carbohydrate, and protein metabolism, and glutathione reductase mediated detoxification. Riboflavin may also be involved in maintaining erythrocyte integrity. This vitamin is essential for healthy skin, nails, and hair. [from NCI]

MedGen UID:
19794
Concept ID:
C0035527
Organic Chemical; Pharmacologic Substance; Vitamin
9.

Methionine preparation

A sulfur-containing essential L-amino acid that is important in many body functions. [from MeSH]

MedGen UID:
9989
Concept ID:
C0025646
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
10.

Choline

A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [from MeSH]

MedGen UID:
3048
Concept ID:
C0008405
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
11.

Betaine preparation

A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341) [from MeSH]

MedGen UID:
2615
Concept ID:
C0005304
Organic Chemical; Pharmacologic Substance
12.

Aging

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from GTR]

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
13.

Curcumin stain

A phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04) [from NCI]

MedGen UID:
1184
Concept ID:
C0010467
Indicator, Reagent, or Diagnostic Aid; Organic Chemical; Pharmacologic Substance
14.

Process

MedGen UID:
923307
Concept ID:
C1951340
Pharmacologic Substance
15.

Methyltransferase inhibitor

MedGen UID:
744708
Concept ID:
C1997663
Pharmacologic Substance
16.

Profound

Having an extremely high degree of severity. For quantitative traits, a deviation of more than five standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
615266
Concept ID:
C0439808
Qualitative Concept
17.

Vitamin, Other

Organic substances belonging to diverse chemical families and present in foods in minute amounts, Vitamins are essential to normal metabolism and biochemical functions, usually as coenzymes. Vitamins can be classified by solubility: lipo-soluble (vitamins A, D, E, K, F) and water-soluble (B- complex). Lack of one or more vitamins in the diet cause metabolic deficiency diseases. (NCI04) [from NCI]

MedGen UID:
203015
Concept ID:
C0973669
Organic Chemical; Pharmacologic Substance; Vitamin
18.

Source

Where something is available or from where it originates. [from NCI]

MedGen UID:
99076
Concept ID:
C0449416
Finding
19.

Sulforaphane

A naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxic, reactive oxygen species. Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale. (NCI04) [from NCI]

MedGen UID:
58034
Concept ID:
C0163159
Organic Chemical; Pharmacologic Substance
20.

Vitamin B6

A group of water-soluble vitamins essential for metabolism and normal physiological functions. B6 vitamins, including pyridoxine, pyridoxal, and pyridoxamine, are converted in vivo to pyridoxal phosphate, a cofactor necessary for the synthesis of amino acids, neurotransmitters, and sphingolipids. More than 100 enzymes involved in protein metabolism require vitamin B6 as a cofactor. Vitamin B6 is essential to red blood cell, nervous system, and immune systems functions and helps maintain normal blood glucose levels. Vitamin B6 is found in a wide variety of foods including cereals, beans, meat, poultry, fish, and some fruits and vegetables. (NCI04) [from NCI]

MedGen UID:
39559
Concept ID:
C0087162
Organic Chemical; Pharmacologic Substance; Vitamin
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