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Decreased antibody level in blood

MedGen UID:
88568
Concept ID:
C0086438
Disease or Syndrome
Synonyms: Decreased immunoglobulin level; Decreased serum immunoglobulin; Hypogammaglobulinemia; Immunoglobulin deficiency; Reduced immunoglobulin levels
SNOMED CT: Hypogammaglobulinemia (119250001)
 

Definition

A decreased level of serum immunoglobulins. It may be inherited or acquired. It is caused by decreased or inefficient production of immunoglobulins from B cells or by a decrease in the numbers of B cells themselves. Low levels of immunoglobulins will affect the immune system's ability to combat bacterial infection. Supplementation of immunoglobulins is needed to prevent worsening outcomes. [from NCI]

Recent clinical studies

Etiology

Wang M, Yang F, Huang D, Huang Y, Zhang X, Wang C, Zhang S, Zhang R
Front Cell Infect Microbiol 2017;7:157. Epub 2017 May 9 doi: 10.3389/fcimb.2017.00157. PMID: 28536674Free PMC Article
Zhang Y, Waterboer T, Haddad RI, Miles BA, Wentz A, Gross ND, Fakhry C, Quon H, Lorch JH, Gourin CG, Clayburgh D, Misiukiewicz KJ, Richmon JD, Andersen PE, Posner MR, D'Souza G
Oral Oncol 2017 Apr;67:77-82. Epub 2017 Feb 15 doi: 10.1016/j.oraloncology.2017.02.004. PMID: 28351584Free PMC Article
Hernández-Romano P, Cámara-Contreras M, Bravo-Sarmiento E, López-Balderas N
Transfusion 2015 Mar;55(3):647-56. Epub 2014 Sep 11 doi: 10.1111/trf.12860. PMID: 25208459
Brinkhof MW, Mayorga O, Bock J, Heininger U, Herzog C
Vaccine 2013 Mar 1;31(11):1490-5. Epub 2013 Jan 14 doi: 10.1016/j.vaccine.2013.01.011. PMID: 23328312
van Tilburg CM, Bierings MB, Berbers GA, Wolfs TF, Pieters R, Bloem AC, Sanders EA
Pediatr Blood Cancer 2012 May;58(5):701-7. Epub 2011 Jul 25 doi: 10.1002/pbc.23258. PMID: 21793184

Diagnosis

Zhang Y, Waterboer T, Haddad RI, Miles BA, Wentz A, Gross ND, Fakhry C, Quon H, Lorch JH, Gourin CG, Clayburgh D, Misiukiewicz KJ, Richmon JD, Andersen PE, Posner MR, D'Souza G
Oral Oncol 2017 Apr;67:77-82. Epub 2017 Feb 15 doi: 10.1016/j.oraloncology.2017.02.004. PMID: 28351584Free PMC Article
Rubin DT, Naik S, Kondragunta V, Rao T, Jain A
Curr Med Res Opin 2017 May;33(5):837-843. Epub 2017 Mar 2 doi: 10.1080/03007995.2017.1289908. PMID: 28145781
Pepper RJ, Draibe JB, Caplin B, Fervenza FC, Hoffman GS, Kallenberg CG, Langford CA, Monach PA, Seo P, Spiera R, William St Clair E, Tchao NK, Stone JH, Specks U, Merkel PA, Salama AD; RAVE-Immune Tolerance Network Research Group.
Arthritis Rheumatol 2017 Jan;69(1):185-193. doi: 10.1002/art.39814. PMID: 27428710Free PMC Article
Zheng J, Xue W, Qing X, Jing X, Hou J, Tian X, Guo Q, He X, Cai J
Clin Transpl 2014:223-30. PMID: 26281149
Maritsi D, Vartzelis G, Soldatou A, Garoufi A, Spyridis N
Clin Exp Rheumatol 2013 Nov-Dec;31(6):969-73. Epub 2013 Jun 26 PMID: 23806191

Therapy

Wang M, Yang F, Huang D, Huang Y, Zhang X, Wang C, Zhang S, Zhang R
Front Cell Infect Microbiol 2017;7:157. Epub 2017 May 9 doi: 10.3389/fcimb.2017.00157. PMID: 28536674Free PMC Article
Pepper RJ, Draibe JB, Caplin B, Fervenza FC, Hoffman GS, Kallenberg CG, Langford CA, Monach PA, Seo P, Spiera R, William St Clair E, Tchao NK, Stone JH, Specks U, Merkel PA, Salama AD; RAVE-Immune Tolerance Network Research Group.
Arthritis Rheumatol 2017 Jan;69(1):185-193. doi: 10.1002/art.39814. PMID: 27428710Free PMC Article
Ahmad SM, Alam J, Afsar NA, Huda N, Kabir Y, Qadri F, Raqib R, Stephensen CB
Hum Vaccin Immunother 2016 Apr 2;12(4):886-93. doi: 10.1080/21645515.2015.1136759. PMID: 27176823Free PMC Article
Zheng J, Xue W, Qing X, Jing X, Hou J, Tian X, Guo Q, He X, Cai J
Clin Transpl 2014:223-30. PMID: 26281149
Vicco MH, Bontempi IA, Rodeles L, Yodice A, Marcipar IS, Bottasso O
Med Microbiol Immunol 2014 Apr;203(2):133-9. Epub 2013 Dec 29 doi: 10.1007/s00430-013-0326-x. PMID: 24374613

Prognosis

Zhang Y, Waterboer T, Haddad RI, Miles BA, Wentz A, Gross ND, Fakhry C, Quon H, Lorch JH, Gourin CG, Clayburgh D, Misiukiewicz KJ, Richmon JD, Andersen PE, Posner MR, D'Souza G
Oral Oncol 2017 Apr;67:77-82. Epub 2017 Feb 15 doi: 10.1016/j.oraloncology.2017.02.004. PMID: 28351584Free PMC Article
Pepper RJ, Draibe JB, Caplin B, Fervenza FC, Hoffman GS, Kallenberg CG, Langford CA, Monach PA, Seo P, Spiera R, William St Clair E, Tchao NK, Stone JH, Specks U, Merkel PA, Salama AD; RAVE-Immune Tolerance Network Research Group.
Arthritis Rheumatol 2017 Jan;69(1):185-193. doi: 10.1002/art.39814. PMID: 27428710Free PMC Article
Boghdadi G, El-Sokkary RH, Elewa EA, Abbas SF
Egypt J Immunol 2015 Jun;22(2):31-39. PMID: 28502142
Zheng J, Xue W, Qing X, Jing X, Hou J, Tian X, Guo Q, He X, Cai J
Clin Transpl 2014:223-30. PMID: 26281149
Brinkhof MW, Mayorga O, Bock J, Heininger U, Herzog C
Vaccine 2013 Mar 1;31(11):1490-5. Epub 2013 Jan 14 doi: 10.1016/j.vaccine.2013.01.011. PMID: 23328312

Clinical prediction guides

Zhang Y, Waterboer T, Haddad RI, Miles BA, Wentz A, Gross ND, Fakhry C, Quon H, Lorch JH, Gourin CG, Clayburgh D, Misiukiewicz KJ, Richmon JD, Andersen PE, Posner MR, D'Souza G
Oral Oncol 2017 Apr;67:77-82. Epub 2017 Feb 15 doi: 10.1016/j.oraloncology.2017.02.004. PMID: 28351584Free PMC Article
Pepper RJ, Draibe JB, Caplin B, Fervenza FC, Hoffman GS, Kallenberg CG, Langford CA, Monach PA, Seo P, Spiera R, William St Clair E, Tchao NK, Stone JH, Specks U, Merkel PA, Salama AD; RAVE-Immune Tolerance Network Research Group.
Arthritis Rheumatol 2017 Jan;69(1):185-193. doi: 10.1002/art.39814. PMID: 27428710Free PMC Article
Hernández-Romano P, Cámara-Contreras M, Bravo-Sarmiento E, López-Balderas N
Transfusion 2015 Mar;55(3):647-56. Epub 2014 Sep 11 doi: 10.1111/trf.12860. PMID: 25208459
Zheng J, Xue W, Qing X, Jing X, Hou J, Tian X, Guo Q, He X, Cai J
Clin Transpl 2014:223-30. PMID: 26281149
Brinkhof MW, Mayorga O, Bock J, Heininger U, Herzog C
Vaccine 2013 Mar 1;31(11):1490-5. Epub 2013 Jan 14 doi: 10.1016/j.vaccine.2013.01.011. PMID: 23328312

Recent systematic reviews

Zwiers C, Scheffer-Rath ME, Lopriore E, de Haas M, Liley HG
Cochrane Database Syst Rev 2018 Mar 18;3:CD003313. doi: 10.1002/14651858.CD003313.pub2. PMID: 29551014
Ma C, Cao L, Zhao J, Ming X, Shang M, Zong H, Du H, Li K, He X, Xu H
Biomed Res Int 2015;2015:294213. Epub 2015 Sep 13 doi: 10.1155/2015/294213. PMID: 26448931Free PMC Article
Li C, Lin L, Zhang W, Zhou L, Wang H, Luo X, Luo H, Cai Y, Zeng C
J Am Heart Assoc 2015 Jun 15;4(6):e001937. doi: 10.1161/JAHA.115.001937. PMID: 26077586Free PMC Article
Cornec D, Avouac J, Youinou P, Saraux A
Autoimmun Rev 2009 May;8(6):515-9. Epub 2009 Jan 30 doi: 10.1016/j.autrev.2009.01.007. PMID: 19186223
Baral S, Sherman SG, Millson P, Beyrer C
Lancet Infect Dis 2007 Oct;7(10):667-74. doi: 10.1016/S1473-3099(07)70237-2. PMID: 17897609

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