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mTOR Inhibitor

MedGen UID:
411559
Concept ID:
C2746052
Pharmacologic Substance
 

Definition

Any substance that inhibits mammalian target of rapamycin (mTOR or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1)), a serine/threonine protein kinase that is active in the control of cell growth, cell proliferation, and cell motility. Inhibition of mTOR can inhibit cell proliferation. [from NCI]

Recent clinical studies

Etiology

Duvoux C, Toso C
Transplant Rev (Orlando) 2015 Jul;29(3):168-74. Epub 2015 Feb 25 doi: 10.1016/j.trre.2015.02.003. PMID: 26071984
He Q, Lin C, Ji S, Chen J
Am J Med Sci 2012 Dec;344(6):491-7. doi: 10.1097/MAJ.0b013e318256754f. PMID: 22902868
Park K, Lee JL, Park I, Park S, Ahn Y, Ahn JH, Ahn S, Song C, Hong JH, Kim CS, Ahn H
Med Oncol 2012 Dec;29(5):3291-7. Epub 2012 Mar 30 doi: 10.1007/s12032-012-0227-7. PMID: 22460837
Niccoli G, Sgueglia GA, Cosentino N, Piro M, Toma A, Cataneo L, Fracassi F, Porto I, Leone AM, Burzotta F, Trani C, Crea F
Eur J Prev Cardiol 2012 Oct;19(5):914-26. Epub 2011 Aug 12 doi: 10.1177/1741826711420001. PMID: 21840968
Schnitzbauer AA, Zuelke C, Graeb C, Rochon J, Bilbao I, Burra P, de Jong KP, Duvoux C, Kneteman NM, Adam R, Bechstein WO, Becker T, Beckebaum S, Chazouillères O, Cillo U, Colledan M, Fändrich F, Gugenheim J, Hauss JP, Heise M, Hidalgo E, Jamieson N, Königsrainer A, Lamby PE, Lerut JP, Mäkisalo H, Margreiter R, Mazzaferro V, Mutzbauer I, Otto G, Pageaux GP, Pinna AD, Pirenne J, Rizell M, Rossi G, Rostaing L, Roy A, Turrion VS, Schmidt J, Troisi RI, van Hoek B, Valente U, Wolf P, Wolters H, Mirza DF, Scholz T, Steininger R, Soderdahl G, Strasser SI, Jauch KW, Neuhaus P, Schlitt HJ, Geissler EK
BMC Cancer 2010 May 11;10:190. doi: 10.1186/1471-2407-10-190. PMID: 20459775Free PMC Article

Diagnosis

Nguyen QD, Sadiq MA, Soliman MK, Agarwal A, Do DV, Sepah YJ
Trans Am Ophthalmol Soc 2016 Aug;114:T3. PMID: 27630374Free PMC Article
Inaba K, Oda K, Ikeda Y, Sone K, Miyasaka A, Kashiyama T, Fukuda T, Uehara Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Kawana K, Yano T, Osuga Y, Fujii T
Gynecol Oncol 2015 Aug;138(2):323-31. Epub 2015 May 29 doi: 10.1016/j.ygyno.2015.05.031. PMID: 26033306
Yasui H, Naka N, Imura Y, Outani H, Kaneko K, Hamada K, Sasagawa S, Araki N, Ueda T, Itoh K, Myoui A, Yoshikawa H
Cancer Lett 2014 May 28;347(1):114-22. Epub 2014 Jan 31 doi: 10.1016/j.canlet.2014.01.027. PMID: 24491407
Petrich AM, Leshchenko V, Kuo PY, Xia B, Thirukonda VK, Ulahannan N, Gordon S, Fazzari MJ, Ye BH, Sparano JA, Parekh S
Clin Cancer Res 2012 May 1;18(9):2534-44. Epub 2012 Feb 14 doi: 10.1158/1078-0432.CCR-11-1407. PMID: 22338016Free PMC Article
Schnitzbauer AA, Zuelke C, Graeb C, Rochon J, Bilbao I, Burra P, de Jong KP, Duvoux C, Kneteman NM, Adam R, Bechstein WO, Becker T, Beckebaum S, Chazouillères O, Cillo U, Colledan M, Fändrich F, Gugenheim J, Hauss JP, Heise M, Hidalgo E, Jamieson N, Königsrainer A, Lamby PE, Lerut JP, Mäkisalo H, Margreiter R, Mazzaferro V, Mutzbauer I, Otto G, Pageaux GP, Pinna AD, Pirenne J, Rizell M, Rossi G, Rostaing L, Roy A, Turrion VS, Schmidt J, Troisi RI, van Hoek B, Valente U, Wolf P, Wolters H, Mirza DF, Scholz T, Steininger R, Soderdahl G, Strasser SI, Jauch KW, Neuhaus P, Schlitt HJ, Geissler EK
BMC Cancer 2010 May 11;10:190. doi: 10.1186/1471-2407-10-190. PMID: 20459775Free PMC Article

Therapy

Sonis S, Andreotta PW, Lyng G
Oral Dis 2017 Apr;23(3):347-352. Epub 2017 Jan 13 doi: 10.1111/odi.12616. PMID: 27896917
Dieterlen MT, John K, Haase S, Garbade J, Tarnok A, Mohr FW, Bittner HB, Barten MJ
Biomarkers 2017 Feb;22(1):86-92. Epub 2016 Jul 22 doi: 10.1080/1354750X.2016.1210676. PMID: 27448205
Andrassy J, Hoffmann VS, Rentsch M, Stangl M, Habicht A, Meiser B, Fischereder M, Jauch KW, Guba M
Transplantation 2012 Dec 27;94(12):1208-17. doi: 10.1097/TP.0b013e3182708e56. PMID: 23269449
He Q, Lin C, Ji S, Chen J
Am J Med Sci 2012 Dec;344(6):491-7. doi: 10.1097/MAJ.0b013e318256754f. PMID: 22902868
Park K, Lee JL, Park I, Park S, Ahn Y, Ahn JH, Ahn S, Song C, Hong JH, Kim CS, Ahn H
Med Oncol 2012 Dec;29(5):3291-7. Epub 2012 Mar 30 doi: 10.1007/s12032-012-0227-7. PMID: 22460837

Prognosis

Koch M, Wiech T, Marget M, Peine S, Thude H, Achilles EG, Fischer L, Lehnhardt A, Thaiss F, Nashan B
Clin Transplant 2015 Nov;29(11):1021-8. Epub 2015 Oct 5 doi: 10.1111/ctr.12624. PMID: 26333844
Duvoux C, Toso C
Transplant Rev (Orlando) 2015 Jul;29(3):168-74. Epub 2015 Feb 25 doi: 10.1016/j.trre.2015.02.003. PMID: 26071984
Atkinson BJ, Cauley DH, Ng C, Millikan RE, Xiao L, Corn P, Jonasch E, Tannir NM
BJU Int 2014 Mar;113(3):376-82. Epub 2013 Dec 2 doi: 10.1111/bju.12420. PMID: 24053120Free PMC Article
Andrassy J, Hoffmann VS, Rentsch M, Stangl M, Habicht A, Meiser B, Fischereder M, Jauch KW, Guba M
Transplantation 2012 Dec 27;94(12):1208-17. doi: 10.1097/TP.0b013e3182708e56. PMID: 23269449
Niccoli G, Sgueglia GA, Cosentino N, Piro M, Toma A, Cataneo L, Fracassi F, Porto I, Leone AM, Burzotta F, Trani C, Crea F
Eur J Prev Cardiol 2012 Oct;19(5):914-26. Epub 2011 Aug 12 doi: 10.1177/1741826711420001. PMID: 21840968

Clinical prediction guides

Seront E, Rottey S, Filleul B, Glorieux P, Goeminne JC, Verschaeve V, Vandenbulcke JM, Sautois B, Boegner P, Gillain A, van Maanen A, Machiels JP
BJU Int 2016 Sep;118(3):408-15. Epub 2016 Feb 11 doi: 10.1111/bju.13415. PMID: 26779597
Inaba K, Oda K, Ikeda Y, Sone K, Miyasaka A, Kashiyama T, Fukuda T, Uehara Y, Arimoto T, Kuramoto H, Wada-Hiraike O, Kawana K, Yano T, Osuga Y, Fujii T
Gynecol Oncol 2015 Aug;138(2):323-31. Epub 2015 May 29 doi: 10.1016/j.ygyno.2015.05.031. PMID: 26033306
Atkinson BJ, Cauley DH, Ng C, Millikan RE, Xiao L, Corn P, Jonasch E, Tannir NM
BJU Int 2014 Mar;113(3):376-82. Epub 2013 Dec 2 doi: 10.1111/bju.12420. PMID: 24053120Free PMC Article
Andrassy J, Hoffmann VS, Rentsch M, Stangl M, Habicht A, Meiser B, Fischereder M, Jauch KW, Guba M
Transplantation 2012 Dec 27;94(12):1208-17. doi: 10.1097/TP.0b013e3182708e56. PMID: 23269449
Niccoli G, Sgueglia GA, Cosentino N, Piro M, Toma A, Cataneo L, Fracassi F, Porto I, Leone AM, Burzotta F, Trani C, Crea F
Eur J Prev Cardiol 2012 Oct;19(5):914-26. Epub 2011 Aug 12 doi: 10.1177/1741826711420001. PMID: 21840968

Recent systematic reviews

Xie X, Jiang Y, Lai X, Xiang S, Shou Z, Chen J
BMC Nephrol 2015 Jul 1;16:91. doi: 10.1186/s12882-015-0078-5. PMID: 26126806Free PMC Article
Murakami N, Riella LV, Funakoshi T
Am J Transplant 2014 Oct;14(10):2317-27. Epub 2014 Aug 21 doi: 10.1111/ajt.12852. PMID: 25146383
Ramirez-Fort MK, Case EC, Rosen AC, Cerci FB, Wu S, Lacouture ME
Am J Clin Oncol 2014 Jun;37(3):266-71. doi: 10.1097/COC.0b013e318277d62f. PMID: 23241507
Andrassy J, Hoffmann VS, Rentsch M, Stangl M, Habicht A, Meiser B, Fischereder M, Jauch KW, Guba M
Transplantation 2012 Dec 27;94(12):1208-17. doi: 10.1097/TP.0b013e3182708e56. PMID: 23269449
He Q, Lin C, Ji S, Chen J
Am J Med Sci 2012 Dec;344(6):491-7. doi: 10.1097/MAJ.0b013e318256754f. PMID: 22902868

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