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Items: 18

1.

Stress

Everyone feels stressed from time to time. Not all stress is bad. All animals have a stress response, and it can be life-saving. But chronic stress can cause both physical and mental harm. There are at least three different types of stress:. -Routine stress related to the pressures of work, family, and other daily responsibilities. -Stress brought about by a sudden negative change, such as losing a job, divorce, or illness. -Traumatic stress, which happens when you are in danger of being seriously hurt or killed. Examples include a major accident, war, assault, or a natural disaster. This type of stress can cause post-traumatic stress disorder (PTSD). Different people may feel stress in different ways. Some people experience digestive symptoms. Others may have headaches, sleeplessness, depressed mood, anger, and irritability. People under chronic stress get more frequent and severe viral infections, such as the flu or common cold. Vaccines, such as the flu shot, are less effective for them. Some people cope with stress more effectively than others. It's important to know your limits when it comes to stress, so you can avoid more serious health effects. NIH: National Institute of Mental Health.  [from MedlinePlus]

MedGen UID:
20971
Concept ID:
C0038435
Finding
2.

Protein Carbonylation

The appearance of carbonyl groups (such as aldehyde or ketone groups) in PROTEINS as the result of several oxidative modification reactions. It is a standard marker for OXIDATIVE STRESS. Carbonylated proteins tend to be more hydrophobic and resistant to proteolysis. [from MeSH]

MedGen UID:
288790
Concept ID:
C1563721
Molecular Function
3.

Hypoxia

A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). [from NCI]

MedGen UID:
66846
Concept ID:
C0242184
Pathologic Function
4.

Insulin

Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. [from NCI]

MedGen UID:
5827
Concept ID:
C0021641
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
5.

Aging

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
6.

Metabolic Response

An evaluation of the metabolic response of the disease to the therapy. [from NCI]

MedGen UID:
884482
Concept ID:
C4054530
Finding
7.

Mitochondrial inheritance

A mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is essentially always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy). [from HPO]

MedGen UID:
165802
Concept ID:
C0887941
Genetic Function
8.

Neurological deficit

Movement impairment. [from NCI_NICHD]

MedGen UID:
101074
Concept ID:
C0521654
Finding
9.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
10.

Superoxol

MedGen UID:
195886
Concept ID:
C0699404
Indicator, Reagent, or Diagnostic Aid; Inorganic Chemical; Pharmacologic Substance
11.

Oxydol

MedGen UID:
181798
Concept ID:
C0949336
Indicator, Reagent, or Diagnostic Aid; Pharmacologic Substance
12.

Perhydrol

MedGen UID:
148496
Concept ID:
C0699403
Indicator, Reagent, or Diagnostic Aid; Inorganic Chemical; Pharmacologic Substance
13.

Senility

MedGen UID:
115903
Concept ID:
C0231337
Finding
14.

Physiological stress

The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions. [from MeSH]

MedGen UID:
105278
Concept ID:
C0449430
Pathologic Function
15.

Oxidative Stress

A condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma. [from NCI_NCI-GLOSS]

MedGen UID:
66929
Concept ID:
C0242606
Cell or Molecular Dysfunction
16.

Superoxide dismutase

a name of an enzyme [from CHV]

MedGen UID:
52578
Concept ID:
C0038838
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
17.

Hydrogen Peroxide

A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. [from MeSH]

MedGen UID:
9340
Concept ID:
C0020281
Indicator, Reagent, or Diagnostic Aid; Inorganic Chemical; Pharmacologic Substance
18.

Electrolyte

substance that while in solution or its pure state will conduct an electric current by means of the movement of ions; in physiology, usually refers to compounds such as sodium, potassium, magnesium and calcium which dissociate fluids into ions that conduct electric currents and that constitute the major force in controlling fluid balance within the body. [from CRISP]

MedGen UID:
3997
Concept ID:
C0013832
Inorganic Chemical; Pharmacologic Substance
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