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Items: 1 to 20 of 38

1.

ALT-801

A recombinant protein consisting of the cytokine interleukin-2 (IL-2) fused to a humanized soluble T-cell receptor (TCR) directed against a tumor suppressor p53-derived antigen with potential immunopotentiating and antineoplastic activities. The TCR moiety of IL-2 recombinant fusion protein ALT-801 binds to tumor cells displaying p53 epitope/MHC complexes; subsequently, the tumor cell-localized IL-2 moiety may stimulate natural killer (NK) cell and T cell cytotoxic immune responses against p53-expressing tumor cells. [from NCI]

MedGen UID:
384537
Concept ID:
C2346454
Amino Acid, Peptide, or Protein; Pharmacologic Substance
2.

Protein Targeting

The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. [GOC:ma] [from GO]

MedGen UID:
216983
Concept ID:
C1159372
Molecular Function
3.

Well Differentiated Liposarcoma

An intermediate malignant mesenchymal neoplasm composed entirely or in part of mature adipocytes that vary in cell size and show at least focal nuclear atypia in adipocytes and stromal cells. Recurrent cytogenetic aberrations are specifically associated with this entity: supernumerary ring and giant marker chromosomes with amplification of MDM2 and, often, CDK4. [from NCI]

MedGen UID:
237164
Concept ID:
C1370889
Neoplastic Process
4.

Thrombocytopenia

A reduction in the number of circulating thrombocytes. [from HPO]

MedGen UID:
52737
Concept ID:
C0040034
Disease or Syndrome; Finding
5.

Experimental Tumor

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. [from MeSH]

MedGen UID:
10216
Concept ID:
C0027659
Experimental Model of Disease; Neoplastic Process
6.

Myocardial infarction

Each year over a million people in the U.S. have a heart attack. About half of them die. Many people have permanent heart damage or die because they don't get help immediately. It's important to know the symptoms of a heart attack and call 9-1-1 if someone is having them. Those symptoms include. -Chest discomfort - pressure, squeezing, or pain . -Shortness of breath . -Discomfort in the upper body - arms, shoulder, neck, back . -Nausea, vomiting, dizziness, lightheadedness, sweating . These symptoms can sometimes be different in women. What exactly is a heart attack? Most heart attacks happen when a clot in the coronary artery blocks the supply of blood and oxygen to the heart. Often this leads to an irregular heartbeat - called an arrhythmia - that causes a severe decrease in the pumping function of the heart. A blockage that is not treated within a few hours causes the affected heart muscle to die. NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

MedGen UID:
10150
Concept ID:
C0027051
Disease or Syndrome
7.

Experimental Malignant Melanoma

Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA. [from MeSH]

MedGen UID:
9945
Concept ID:
C0025205
Experimental Model of Disease; Neoplastic Process
8.

Malignant melanoma

Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal, or ugly looking.. Thinking of ABCDE can help you remember what to watch for:. - Asymmetry - the shape of one half does not match the other. - Border - the edges are ragged, blurred or irregular. - Color - the color is uneven and may include shades of black, brown and tan. - Diameter - there is a change in size, usually an increase. -Evolving - the mole has changed over the past few weeks or months. Surgery is the first treatment of all stages of melanoma. Other treatments include chemotherapy and radiation, biologic, and targeted therapies. Biologic therapy boosts your body's own ability to fight cancer. Targeted therapy uses substances that attack cancer cells without harming normal cells. NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
9944
Concept ID:
C0025202
Neoplastic Process
9.

Infarct

tissue death caused by blocked blood circulation [from CHV]

MedGen UID:
9461
Concept ID:
C0021308
Pathologic Function
10.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
11.

Melanoma

The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea). [from HPO]

MedGen UID:
505377
Concept ID:
CN002586
Finding
12.

Myocardial infarction

Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin. [from HPO]

MedGen UID:
504896
Concept ID:
CN001509
Finding
13.

Thrombocytopenia

MedGen UID:
472158
Concept ID:
CN130080
Disease or Syndrome
14.

Disease Response

The pathologic and/or clinical changes that result from treatment. The changes may include eradication of detectable disease, stabilization of disease, or disease progression. [from NCI]

MedGen UID:
309976
Concept ID:
C1704632
Finding
15.

Stable Disease

Cancer that is neither decreasing nor increasing in extent or severity. [from NCI]

MedGen UID:
151811
Concept ID:
C0677946
Finding
16.

Context

The universe of discourse that surrounds a language unit and helps to determine its interpretation. [from NCI]

MedGen UID:
105274
Concept ID:
C0449255
Finding
17.

Severity

The intensity or degree of a manifestation. [from HPO]

MedGen UID:
101096
Concept ID:
C0522510
Qualitative Concept
18.

Neoplasm Metastasis

The spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a "metastatic tumor" or a "metastasis." The metastatic tumor contains cells that are like those in the original (primary) tumor. [from NCI]

MedGen UID:
45032
Concept ID:
C0027627
Neoplastic Process
19.

Ro-23-6019

MedGen UID:
214655
Concept ID:
C0919268
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
20.

Clinical finding

clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient. [from CRISP]

MedGen UID:
19974
Concept ID:
C0037088
Sign or Symptom
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