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Items: 1 to 20 of 67

1.

Atypical hemolytic uremic syndrome

Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD). [from GTR]

MedGen UID:
444141
Concept ID:
C2931788
Disease or Syndrome
2.

Eculizumab

A humanized monoclonal antibody directed against terminal complement protein C5. Eculizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and blocking the complement-mediated destruction of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. (NCI05) [from NCI]

MedGen UID:
323806
Concept ID:
C1541483
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
3.

Hemolytic uremic syndrome

A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE. [from MeSH]

MedGen UID:
42403
Concept ID:
C0019061
Disease or Syndrome
4.

Syndrome

A characteristic symptom complex. [from MeSH]

MedGen UID:
11688
Concept ID:
C0039082
Disease or Syndrome
5.

Borries syndrome

MedGen UID:
542920
Concept ID:
C0270677
Disease or Syndrome
6.

Hemolytic-uremic syndrome

MedGen UID:
505834
Concept ID:
CN004936
Finding
7.

Recurrence

The return of a sign, symptom, or disease after a remission. [from MeSH]

MedGen UID:
416712
Concept ID:
C2825055
Pathologic Function
8.

Mycophenolate mofetil

The morpholinoethyl ester of mycophenolic acid (MPA) with potent immunosuppressive properties. Mycophenolate stops T-cell and B-cell proliferation through selective inhibition of the de novo pathway of purine biosynthesis. In vivo, the active metabolite, MPA, reversibly inhibits inosine 5'-monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of guanine nucleotides. MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types. (NCI04) [from NCI]

MedGen UID:
60443
Concept ID:
C0209368
Organic Chemical; Pharmacologic Substance
9.

tacrolimus

A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [from NCI]

MedGen UID:
43111
Concept ID:
C0085149
Organic Chemical; Pharmacologic Substance
10.

Transplantation

MedGen UID:
881115
Concept ID:
CN236682
Disease or Syndrome
11.

Kidney Transplantation

MedGen UID:
880926
Concept ID:
CN236685
Disease or Syndrome
12.

Invasive meningococcal disease

MedGen UID:
845574
Concept ID:
C3873491
Disease or Syndrome
13.

Complement inhibitor

Compounds that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host. [from MeSH]

MedGen UID:
297405
Concept ID:
C1564892
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
14.

Mycophenolate

The morpholinoethyl ester of mycophenolic acid (MPA). As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation. MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides. (NCI04) [from NCI]

MedGen UID:
168139
Concept ID:
C0883242
Organic Chemical; Pharmacologic Substance
15.

Chronic

Slow, creeping onset, slow progress and long continuance of disease manifestations. [from HPO]

MedGen UID:
104657
Concept ID:
C0205191
Temporal Concept
16.

Multiple endocrine neoplasia

A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively. [from MeSH]

MedGen UID:
45036
Concept ID:
C0027662
Neoplastic Process
17.

Patient immunosuppressed

A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation. [from MeSH]

MedGen UID:
39272
Concept ID:
C0085393
Finding
18.

Menveo

MedGen UID:
473679
Concept ID:
C2741594
Immunologic Factor; Pharmacologic Substance
19.

Thrombotic microangiopathy

Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation. [from MeSH]

MedGen UID:
403479
Concept ID:
C2717961
Disease or Syndrome
20.

Renal insufficiency

A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism. [from HPO]

MedGen UID:
332529
Concept ID:
C1565489
Disease or Syndrome
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