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Manuka Honey

MedGen UID:
389375
Concept ID:
C2347055
Pharmacologic Substance
 

Definition

A monofloral honey with potential wound repair and antibacterial activities. Manuka honey is produced by bees fed on the flowers of the New Zealand Manuka bush (Leptospermum scoparium). Manuka honey contains a significant higher concentration of the 1,2-dicarbonyl compound methylglyoxal, which may account for its antibacterial activity; this agent may release small amounts of hydrogen peroxide which may also contribute to its antibacterial activity. Manuka honey has been reported to stimulate the formation of new blood capillaries and the growth of fibroblasts and epithelial cells when applied topically to wounds. [from NCI]

Recent clinical studies

Etiology

Malhotra R, Ziahosseini K, Poitelea C, Litwin A, Sagili S
Ophthal Plast Reconstr Surg 2017 Jul/Aug;33(4):268-272. doi: 10.1097/IOP.0000000000000743. PMID: 27429228
Rupesh S, Winnier JJ, Nayak UA, Rao AP, Reddy NV, Peter J
J Indian Soc Pedod Prev Dent 2014 Jul-Sep;32(3):212-9. doi: 10.4103/0970-4388.135827. PMID: 25001440
Nicoara CD, Singh M, Jester I, Reda B, Parikh DH
Pediatr Surg Int 2014 May;30(5):515-20. Epub 2014 Mar 6 doi: 10.1007/s00383-014-3490-1. PMID: 24599698
Fernandez-Cabezudo MJ, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, al-Ramadi BK
PLoS One 2013;8(2):e55993. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0055993. PMID: 23409104Free PMC Article
Maddocks SE, Lopez MS, Rowlands RS, Cooper RA
Microbiology 2012 Mar;158(Pt 3):781-90. Epub 2012 Jan 31 doi: 10.1099/mic.0.053959-0. PMID: 22294681

Diagnosis

Bardy J, Molassiotis A, Ryder WD, Mais K, Sykes A, Yap B, Lee L, Kaczmarski E, Slevin N
Br J Oral Maxillofac Surg 2012 Apr;50(3):221-6. Epub 2011 Jun 1 doi: 10.1016/j.bjoms.2011.03.005. PMID: 21636188
Lin SM, Molan PC, Cursons RT
Eur J Clin Microbiol Infect Dis 2011 Apr;30(4):569-74. Epub 2010 Dec 17 doi: 10.1007/s10096-010-1121-x. PMID: 21165664
Nasir NA, Halim AS, Singh KK, Dorai AA, Haneef MN
BMC Complement Altern Med 2010 Jun 24;10:31. doi: 10.1186/1472-6882-10-31. PMID: 20576085Free PMC Article
Lin SM, Molan PC, Cursons RT
Eur J Clin Microbiol Infect Dis 2009 Apr;28(4):339-44. Epub 2008 Sep 26 doi: 10.1007/s10096-008-0630-3. PMID: 18818958
Cooper RA, Molan PC, Krishnamoorthy L, Harding KG
Eur J Clin Microbiol Infect Dis 2001 Oct;20(10):758-9. PMID: 11757984

Therapy

Fogh SE, Deshmukh S, Berk LB, Dueck AC, Roof K, Yacoub S, Gergel T, Stephans K, Rimner A, DeNittis A, Pablo J, Rineer J, Williams TM, Bruner D
Int J Radiat Oncol Biol Phys 2017 Mar 15;97(4):786-796. Epub 2016 Nov 23 doi: 10.1016/j.ijrobp.2016.11.022. PMID: 28244415Free PMC Article
Malhotra R, Ziahosseini K, Poitelea C, Litwin A, Sagili S
Ophthal Plast Reconstr Surg 2017 Jul/Aug;33(4):268-272. doi: 10.1097/IOP.0000000000000743. PMID: 27429228
Tenci M, Rossi S, Bonferoni MC, Sandri G, Boselli C, Di Lorenzo A, Daglia M, Icaro Cornaglia A, Gioglio L, Perotti C, Caramella C, Ferrari F
Int J Pharm 2016 Jul 25;509(1-2):59-70. Epub 2016 May 20 doi: 10.1016/j.ijpharm.2016.05.035. PMID: 27215534
Hawley P, Hovan A, McGahan CE, Saunders D
Support Care Cancer 2014 Mar;22(3):751-61. Epub 2013 Nov 13 doi: 10.1007/s00520-013-2031-0. PMID: 24221577
Fernandez-Cabezudo MJ, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, al-Ramadi BK
PLoS One 2013;8(2):e55993. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0055993. PMID: 23409104Free PMC Article

Prognosis

Yabes JM, White BK, Murray CK, Sanchez CJ, Mende K, Beckius ML, Zera WC, Wenke JC, Akers KS
Med Mycol 2017 Apr 1;55(3):334-343. doi: 10.1093/mmy/myw070. PMID: 27601610Free PMC Article
Malhotra R, Ziahosseini K, Poitelea C, Litwin A, Sagili S
Ophthal Plast Reconstr Surg 2017 Jul/Aug;33(4):268-272. doi: 10.1097/IOP.0000000000000743. PMID: 27429228
Nicoara CD, Singh M, Jester I, Reda B, Parikh DH
Pediatr Surg Int 2014 May;30(5):515-20. Epub 2014 Mar 6 doi: 10.1007/s00383-014-3490-1. PMID: 24599698
English HK, Pack AR, Molan PC
J Int Acad Periodontol 2004 Apr;6(2):63-7. PMID: 15125017
Cooper RA, Molan PC, Krishnamoorthy L, Harding KG
Eur J Clin Microbiol Infect Dis 2001 Oct;20(10):758-9. PMID: 11757984

Clinical prediction guides

Yabes JM, White BK, Murray CK, Sanchez CJ, Mende K, Beckius ML, Zera WC, Wenke JC, Akers KS
Med Mycol 2017 Apr 1;55(3):334-343. doi: 10.1093/mmy/myw070. PMID: 27601610Free PMC Article
Malhotra R, Ziahosseini K, Poitelea C, Litwin A, Sagili S
Ophthal Plast Reconstr Surg 2017 Jul/Aug;33(4):268-272. doi: 10.1097/IOP.0000000000000743. PMID: 27429228
Fernandez-Cabezudo MJ, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, al-Ramadi BK
PLoS One 2013;8(2):e55993. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0055993. PMID: 23409104Free PMC Article
Maddocks SE, Lopez MS, Rowlands RS, Cooper RA
Microbiology 2012 Mar;158(Pt 3):781-90. Epub 2012 Jan 31 doi: 10.1099/mic.0.053959-0. PMID: 22294681
Henriques AF, Jenkins RE, Burton NF, Cooper RA
Eur J Clin Microbiol Infect Dis 2011 Feb;30(2):167-71. Epub 2010 Oct 10 doi: 10.1007/s10096-010-1065-1. PMID: 20936493

Recent systematic reviews

Varshney R, Lee JT
Expert Opin Drug Deliv 2017 Feb;14(2):257-271. Epub 2016 Aug 12 doi: 10.1080/17425247.2016.1214563. PMID: 27500891
Adderley UJ, Holt IG
Cochrane Database Syst Rev 2014 May 15;(5):CD003948. doi: 10.1002/14651858.CD003948.pub3. PMID: 24832784
Rudmik L, Hoy M, Schlosser RJ, Harvey RJ, Welch KC, Lund V, Smith TL
Int Forum Allergy Rhinol 2013 Apr;3(4):281-98. Epub 2012 Oct 8 doi: 10.1002/alr.21096. PMID: 23044832
Doerler M, Reich-Schupke S, Altmeyer P, Stücker M
J Dtsch Dermatol Ges 2012 Sep;10(9):624-32. Epub 2012 May 16 doi: 10.1111/j.1610-0387.2012.07952.x. PMID: 22591415
Eekhof JA, Van Wijk B, Knuistingh Neven A, van der Wouden JC
Cochrane Database Syst Rev 2012 Apr 18;(4):CD001541. doi: 10.1002/14651858.CD001541.pub3. PMID: 22513901

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