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Items: 16

1.

Tuberculosis

A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. [from NCI]

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
2.

Serine

A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04) [from NCI]

MedGen UID:
11382
Concept ID:
C0036720
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
3.

Thyroid hormone plasma membrane transport defect

MedGen UID:
396060
Concept ID:
C1861101
Disease or Syndrome
4.

Mutant

An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). [from NCI]

MedGen UID:
109303
Concept ID:
C0596988
Cell or Molecular Dysfunction
5.

Infection

The invasion of an organism's body tissues by disease-causing agents and their multiplication, as well as the reaction by the host to these organisms and/or toxins that the organisms produce. [from NCI]

MedGen UID:
811352
Concept ID:
C3714514
Pathologic Function
6.

Betaserc

brand name of betahistine hydrochloride [from CHV]

MedGen UID:
102376
Concept ID:
C0162331
Organic Chemical; Pharmacologic Substance
7.

Mutagenesis

Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS. [from MeSH]

MedGen UID:
86969
Concept ID:
C0079866
Molecular Function
8.

Primary cortisol resistance

MedGen UID:
443921
Concept ID:
C2930863
Disease or Syndrome
9.

Amino Acid Biosynthesis

Amino Acid Biosynthesis consists of cellular enzymatic reactions that produce amino acids, organic compounds containing an amino and a carboxyl group and often used in protein synthesis by the formation of peptide bonds during ribosomal translation of mRNA. Several important amino acids, such as the neurotransmitter g-aminobutyric acid, have other functions than protein synthesis. [from NCI]

MedGen UID:
154539
Concept ID:
C0596074
Molecular Function
10.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
11.

Gram-Positive Bacterial Infections

Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method. [from MeSH]

MedGen UID:
39283
Concept ID:
C0085426
Disease or Syndrome
12.

Protein binding

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. [from MeSH]

MedGen UID:
18704
Concept ID:
C0033618
Molecular Function
13.

Bacterial infection by site

An acute infectious disorder that is caused by gram positive or gram negative bacteria; representative examples include pneumococcal, streptococcal, salmonella, and meningeal infections. [from NCI]

MedGen UID:
14012
Concept ID:
C0004623
Disease or Syndrome
14.

Mycobacteriosis

Infection due to organisms from the genus Mycobacteria. [from NCI]

MedGen UID:
6479
Concept ID:
C0026918
Disease or Syndrome
15.

Bacterial Infections and Mycoses

Infections caused by bacteria and fungi, general, specified, or unspecified. [from MeSH]

MedGen UID:
2161
Concept ID:
C0004615
Disease or Syndrome
16.

Infection caused by Actinomycetales

An infectious process caused by actinomycetales which is an order of Actinobacteria. [from NCI]

MedGen UID:
1732
Concept ID:
C0001255
Disease or Syndrome
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