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Mesothelioma, malignant(MESOM)

MedGen UID:
91062
Concept ID:
C0345967
Neoplastic Process
Synonyms: MESOM
Modes of inheritance:
Somatic mutation
MedGen UID:
107465
Concept ID:
C0544886
Cell or Molecular Dysfunction
Sources: HPO, OMIM
A mode of inheritance in which a trait or disorder results from a de novo mutation occurring after conception, rather than being inherited from a preceding generation.
Somatic mutation (HPO, OMIM)
SNOMED CT: Mesothelioma, malignant (62064005); Malignant mesothelioma (62064005); Mesothelioma (malignant, clinical disorder) (109378008); Malignant mesothelioma (109378008); Cancer, mesothelioma (109378008)
 
Genes (locations): BCL10 (1p22.3); WT1 (11p13)
OMIM®: 156240
HPO: HP:0100001

Definition

Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21. [from OMIM]

Clinical features

Mesothelioma, malignant
MedGen UID:
91062
Concept ID:
C0345967
Neoplastic Process
Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21.

Conditions with this feature

Mesothelioma, malignant
MedGen UID:
91062
Concept ID:
C0345967
Neoplastic Process
Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21.

Recent clinical studies

Etiology

Abdel-Rahman O, Elsayed Z, Mohamed H, Eltobgy M
Cochrane Database Syst Rev 2018 Jan 8;1:CD012605. doi: 10.1002/14651858.CD012605.pub2. PMID: 29309720
Nguyen BH, Montgomery R, Fadia M, Wang J, Ali S
Asia Pac J Clin Oncol 2018 Feb;14(1):69-73. Epub 2017 Nov 3 doi: 10.1111/ajco.12788. PMID: 29105302
Rusiecki J, Stewart P, Lee D, Alexander M, Krstev S, Silverman D, Blair A
Arch Environ Occup Health 2018 Jan 2;73(1):4-18. Epub 2017 Feb 6 doi: 10.1080/19338244.2017.1289891. PMID: 28166467
Parisi E, Romeo A, Sarnelli A, Ghigi G, Bellia SR, Neri E, Micheletti S, Dipalma B, Arpa D, Furini G, Burgio MA, Genestreti G, Gurioli C, Sanna S, Bovolato P, Rea F, Storme G, Scarpi E, Arienti C, Tesei A, Polico R
Cancer Radiother 2017 Dec;21(8):766-773. Epub 2017 Nov 11 doi: 10.1016/j.canrad.2017.05.007. PMID: 29132803
Habougit C, Trombert-Paviot B, Karpathiou G, Casteillo F, Bayle-Bleuez S, Fournel P, Vergnon JM, Tiffet O, Péoc'h M, Forest F
Virchows Arch 2017 Jun;470(6):639-646. Epub 2017 Mar 27 doi: 10.1007/s00428-017-2109-z. PMID: 28349237

Diagnosis

Davidson B, Pinamonti M, Cuevas D, Holth A, Zeppa P, Hager T, Wohlschlaeger J, Tötsch M
Virchows Arch 2018 Mar;472(3):425-432. Epub 2017 Nov 24 doi: 10.1007/s00428-017-2273-1. PMID: 29170871
Abramavicius S, Zemaitis M, Pilvinis V, Kadusevicius E
Medicine (Baltimore) 2017 Dec;96(48):e8995. doi: 10.1097/MD.0000000000008995. PMID: 29310415Free PMC Article
Burt BM, Lee HS, Lenge De Rosen V, Hamaji M, Groth SS, Wheeler TM, Sugarbaker DJ
Ann Thorac Surg 2017 Nov;104(5):1679-1687. Epub 2017 Sep 28 doi: 10.1016/j.athoracsur.2017.06.042. PMID: 28964420
Ward RE, Ali SA, Kuhar M
J Cutan Pathol 2017 Dec;44(12):1057-1063. Epub 2017 Sep 11 doi: 10.1111/cup.13026. PMID: 28800180
Habougit C, Trombert-Paviot B, Karpathiou G, Casteillo F, Bayle-Bleuez S, Fournel P, Vergnon JM, Tiffet O, Péoc'h M, Forest F
Virchows Arch 2017 Jun;470(6):639-646. Epub 2017 Mar 27 doi: 10.1007/s00428-017-2109-z. PMID: 28349237

Therapy

Abdel-Rahman O, Elsayed Z, Mohamed H, Eltobgy M
Cochrane Database Syst Rev 2018 Jan 8;1:CD012605. doi: 10.1002/14651858.CD012605.pub2. PMID: 29309720
Abramavicius S, Zemaitis M, Pilvinis V, Kadusevicius E
Medicine (Baltimore) 2017 Dec;96(48):e8995. doi: 10.1097/MD.0000000000008995. PMID: 29310415Free PMC Article
Thomas R, Fysh ETH, Smith NA, Lee P, Kwan BCH, Yap E, Horwood FC, Piccolo F, Lam DCL, Garske LA, Shrestha R, Kosky C, Read CA, Murray K, Lee YCG
JAMA 2017 Nov 21;318(19):1903-1912. doi: 10.1001/jama.2017.17426. PMID: 29164255Free PMC Article
Odgerel CO, Takahashi K, Sorahan T, Driscoll T, Fitzmaurice C, Yoko-O M, Sawanyawisuth K, Furuya S, Tanaka F, Horie S, Zandwijk NV, Takala J
Occup Environ Med 2017 Dec;74(12):851-858. Epub 2017 Sep 2 doi: 10.1136/oemed-2017-104298. PMID: 28866609Free PMC Article
Facchetti G, Petrella F, Spaggiari L, Rimoldi I
Eur J Med Chem 2017 Dec 15;142:266-270. Epub 2017 Aug 2 doi: 10.1016/j.ejmech.2017.07.063. PMID: 28800871

Prognosis

Nguyen BH, Montgomery R, Fadia M, Wang J, Ali S
Asia Pac J Clin Oncol 2018 Feb;14(1):69-73. Epub 2017 Nov 3 doi: 10.1111/ajco.12788. PMID: 29105302
Thomas R, Fysh ETH, Smith NA, Lee P, Kwan BCH, Yap E, Horwood FC, Piccolo F, Lam DCL, Garske LA, Shrestha R, Kosky C, Read CA, Murray K, Lee YCG
JAMA 2017 Nov 21;318(19):1903-1912. doi: 10.1001/jama.2017.17426. PMID: 29164255Free PMC Article
Binazzi A, Marinaccio A, Corfiati M, Bruno C, Fazzo L, Pasetto R, Pirastu R, Biggeri A, Catelan D, Comba P, Zona A
Scand J Work Environ Health 2017 Nov 1;43(6):550-559. Epub 2017 Oct 6 doi: 10.5271/sjweh.3676. PMID: 28985440
Ward RE, Ali SA, Kuhar M
J Cutan Pathol 2017 Dec;44(12):1057-1063. Epub 2017 Sep 11 doi: 10.1111/cup.13026. PMID: 28800180
Habougit C, Trombert-Paviot B, Karpathiou G, Casteillo F, Bayle-Bleuez S, Fournel P, Vergnon JM, Tiffet O, Péoc'h M, Forest F
Virchows Arch 2017 Jun;470(6):639-646. Epub 2017 Mar 27 doi: 10.1007/s00428-017-2109-z. PMID: 28349237

Clinical prediction guides

Abdel-Rahman O, Elsayed Z, Mohamed H, Eltobgy M
Cochrane Database Syst Rev 2018 Jan 8;1:CD012605. doi: 10.1002/14651858.CD012605.pub2. PMID: 29309720
Parisi E, Romeo A, Sarnelli A, Ghigi G, Bellia SR, Neri E, Micheletti S, Dipalma B, Arpa D, Furini G, Burgio MA, Genestreti G, Gurioli C, Sanna S, Bovolato P, Rea F, Storme G, Scarpi E, Arienti C, Tesei A, Polico R
Cancer Radiother 2017 Dec;21(8):766-773. Epub 2017 Nov 11 doi: 10.1016/j.canrad.2017.05.007. PMID: 29132803
Burt BM, Lee HS, Lenge De Rosen V, Hamaji M, Groth SS, Wheeler TM, Sugarbaker DJ
Ann Thorac Surg 2017 Nov;104(5):1679-1687. Epub 2017 Sep 28 doi: 10.1016/j.athoracsur.2017.06.042. PMID: 28964420
Habougit C, Trombert-Paviot B, Karpathiou G, Casteillo F, Bayle-Bleuez S, Fournel P, Vergnon JM, Tiffet O, Péoc'h M, Forest F
Virchows Arch 2017 Jun;470(6):639-646. Epub 2017 Mar 27 doi: 10.1007/s00428-017-2109-z. PMID: 28349237
Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
J Korean Med Sci 2014 Nov;29(11):1464-72. Epub 2014 Nov 4 doi: 10.3346/jkms.2014.29.11.1464. PMID: 25408576Free PMC Article

Recent systematic reviews

Abdel-Rahman O, Elsayed Z, Mohamed H, Eltobgy M
Cochrane Database Syst Rev 2018 Jan 8;1:CD012605. doi: 10.1002/14651858.CD012605.pub2. PMID: 29309720
Marsh GM PhD Face, Riordan AS Mph, Keeton KA Mph, Benson SM PhD
Occup Environ Med 2017 Nov;74(11):838-846. Epub 2017 Sep 21 doi: 10.1136/oemed-2017-104383. PMID: 28935666
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639
Arnold DT, Clive AO
Curr Opin Pulm Med 2017 Jul;23(4):357-364. doi: 10.1097/MCP.0000000000000385. PMID: 28426469
Cortes-Dericks L, Schmid RA
Respir Res 2017 Apr 12;18(1):58. doi: 10.1186/s12931-017-0546-5. PMID: 28403901Free PMC Article

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