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1.

Psoriasis

A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. [from MeSH]

MedGen UID:
10997
Concept ID:
C0033860
Disease or Syndrome
2.

Episodic

Applied to a sign, symptom, or other manifestation that occurs at least twice and potentially multiple times but separated by an interval in whichthe sign, symptom, or manifestation is not present. [from HPO]

MedGen UID:
910017
Concept ID:
CN240220
Organism Attribute
3.

Inflammatory abnormality of the skin

The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes. [from HPO]

MedGen UID:
849741
Concept ID:
C3875321
Disease or Syndrome
4.

Pustular psoriasis

MedGen UID:
508876
Concept ID:
C0152081
Disease or Syndrome
5.

Psoriasis

A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales). [from HPO]

MedGen UID:
505592
Concept ID:
CN003401
Finding
6.

Pustular psoriasis, generalized

Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (123260) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris (PV; see 177900); however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013). GPP in association with sterile multifocal osteomyelitis and periostitis (612852) is caused by mutation in the IL1RN gene (147679). Capon (2013) noted that the percentage of GPP patients reported to be negative for mutation in IL36RN ranges from 51 to 84%, indicative of genetic heterogeneity in the generalized pustular form of psoriasis. For a discussion of genetic heterogeneity of psoriasis, see PSORS1 (177900). [from GTR]

MedGen UID:
473074
Concept ID:
C0343055
Disease or Syndrome
7.

Generalized

Affecting all regions without specificity of distribution. [from HPO]

MedGen UID:
104661
Concept ID:
C0205246
Spatial Concept
8.

Severe

Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
104640
Concept ID:
C0205082
Qualitative Concept
9.

Episodic fever

Cycles of fever with intervening periods of normothermia. [from NCI]

MedGen UID:
82922
Concept ID:
C0277799
Finding; Finding
10.

Inflammatory abnormality of the skin

An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis. [from NCI]

MedGen UID:
4233
Concept ID:
C0011603
Disease or Syndrome
11.

Frequency

MedGen UID:
91210
Concept ID:
C0376249
Temporal Concept
12.

Inflammation

A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [from NCI]

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
13.

Fever

A condition characterized by an abnormally high body temperature. In a hyperthermic state, the hypothalamic set-point is normal but body temperature increases and overrides the ability to lose heat, resulting from exogenous heat exposure or endogenous heat production. [from NCI]

MedGen UID:
5169
Concept ID:
C0015967
Sign or Symptom
14.

Neutrophilia

MedGen UID:
777102
Concept ID:
C3665444
Disease or Syndrome
15.

Pustule

A small elevation of the skin containing cloudy or purulent material usually consisting of necrotic inflammatory cells. [from HPO]

MedGen UID:
639088
Concept ID:
C0542346
Pathologic Function
16.

Spelters fever

MedGen UID:
538578
Concept ID:
C0264454
Disease or Syndrome
17.

Immune dysregulation

MedGen UID:
335001
Concept ID:
C1844666
Finding
18.

Unrelated

Not connected or associated e.g. by kinship. [from NCI]

MedGen UID:
99027
Concept ID:
C0445356
Finding
19.

Disease Attributes

Clinical characteristics of disease or illness. [from MeSH]

MedGen UID:
199876
Concept ID:
C0752357
Disease or Syndrome
20.

Genetic predisposition

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. [from MeSH]

MedGen UID:
137259
Concept ID:
C0314657
Organism Attribute
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